Maier, AG and Van ooij, C. 2022. Table 1 - The role of cholesterol in invasion and growth of malaria parasites. [Online]. Frontiers. Available from: https://doi.org/10.3389/fcimb.2022.984049.s001
Maier, AG and Van ooij, C. Table 1 - The role of cholesterol in invasion and growth of malaria parasites [Internet]. Frontiers; 2022. Available from: https://doi.org/10.3389/fcimb.2022.984049.s001
Maier, AG and Van ooij, C (2022). Table 1 - The role of cholesterol in invasion and growth of malaria parasites. [Data Collection]. Frontiers. https://doi.org/10.3389/fcimb.2022.984049.s001
Description
Malaria parasites are unicellular eukaryotic pathogens that develop through a complex lifecycle involving two hosts, an anopheline mosquito and a vertebrate host. Throughout this lifecycle, the parasite encounters widely differing conditions and survives in distinct ways, from an intracellular lifestyle in the vertebrate host to exclusively extracellular stages in the mosquito. Although the parasite relies on cholesterol for its growth, the parasite has an ambiguous relationship with cholesterol: cholesterol is required for invasion of host cells by the parasite, including hepatocytes and erythrocytes, and for the development of the parasites in those cells. However, the parasite is unable to produce cholesterol itself and appears to remove cholesterol actively from its own plasma membrane, thereby setting up a cholesterol gradient inside the infected host erythrocyte. Overall a picture emerges in which the parasite relies on host cholesterol and carefully controls its transport. Here, we describe the role of cholesterol at the different lifecycle stages of the parasites.
Keywords
Data capture method | Summary |
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Date (Date published in a 3rd party system) | 16 September 2022 |
Language(s) of written materials | English |
Data Creators | Maier, AG and Van ooij, C |
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LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Department of Infection Biology |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 26 Sep 2022 09:07 |
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Last Modified | 26 Sep 2022 09:07 |
Publisher | Frontiers |