CHANGE Cohort 2: Chronic disease outcomes after Severe Acute Malnutrition (ChroSAM). Malawi

Kerac, M

; Anujuo, K

; Lelijveld, N

; Kanjala, C

; Chimwezi, E and Nyirenda, M

(2022). CHANGE Cohort 2: Chronic disease outcomes after Severe Acute Malnutrition (ChroSAM). Malawi. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.00002657.

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A dataset containing information collected from a prospective cohort of children originally admitted for treatment of severe acute malnutrition (SAM) in Blantyre, Malawi during 2006 and 2007. It includes health and anthropometric data from admission to care, during treatment, at discharge, at 1 year post-discharge, and at 7-years post-discharge. During original admission to care, data was collected as part of a randomised controlled trial into the effects of pre- and probiotics on treatment recovery – findings were null (trial registry number ISRCTN19364765). At the most recent follow-up in 2013/14, data pertaining to NCD risk were also collected, and data on 1 sibling control and 1 community control (age and sex matched) was also added.

Additional Information

This dataset is not held in the LSHTM repository. Data management and access arrangements for this dataset are handled in-country by the study investigators, in accordance with the study ethics approvals. Please read the data codebook and make a note of variables that you wish to request prior to applying for access. Access requests submitted through the LSHTM repository will be passed onto the relevant research team for follow-up.

Keywords

Post-malnutrition growth; Childhood; Non-communicable diseases (NCD); Anthropometry; Malnutrition; Severe acute malnutrition; Growth condition; Rehabilitation; Diabetes; Hypertension; Obesity; Risk factors; Long-term outcome

Parent Collection(s)

note_stack CHANGE Project (CHild malnutrition & Adult NCD: Generating Evidence on mechanistic links to inform future policy/practice)

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Description of data capture	The data comes from a prospective cohort of children, recruited during a randomised controlled trial with null findings, while they were being treated for severe malnutrition (PRONUT study). They were then followed up at 1 year post-discharge (FuSAM). This was a secondary analysis of data collected from children treated for severe wasting and/or nutritional oedema in 2006/7 in Malawi, and followed up seven years later to assess risk of NCD. The objectives of the current analysis were to: (1) Explore rates of Post-malnutrition growth (PMGr) based on a variety of weight- and height-related definitions; (2) Explore different ways of categorising these PMGr definitions into fast and slow; and (3) Explore associations and patterns between the different definitions and categorisations of PMGr with indicators of NCD risk. The original data comes from a prospective cohort of children, recruited during a randomised controlled trial with null findings, while they were being treated for severe malnutrition (PRONUT study). They were then followed up at 1 year post-discharge (FuSAM study) and again at 7-years post-discharge (ChroSAM study), where the focus was more on indicators of NCD risk. Interviews were conducted face-to-face by trained nurses and data collectors, on the ward and then at the households of each participant, in the local language. Details of the data collection methods including anthropometry methods, lab tests, and questionnaires can be found in a number of publications (Kerac et al., 2009, Kerac et al., 2014, Lelijveld et al., 2016). Key features include: All children admitted for treatment during the recruitment period were eligible for inclusion. Admission criteria for treatment were weight-for-length z-score <70% median (using NCHS reference) and/or MUAC<110 mm and/or bilateral oedema. All patients were admitted for initial inpatient treatment, following the WHO 3-stage protocol at that time: stabilisation with F75 therapeutic milk, transition phase where RUTF was introduced to the diet alongside F75, and then rehabilitation phase where children were discharged with a 2-week ration of RUTF to continue their recovery at home and return to the ward for monitoring and to collect another ration every 2 weeks until recovery. Children were discharged from outpatient therapeutic care following 2 consecutive fortnightly visits at or above target weight of 80% median weight-for-height. Minimum time in outpatient care was therefore 4 weeks. Maximum time was 10 weeks. This analysis was coordinated with similar analyses of cohort data for children treated for severe malnutrition in Jamaica and Ethiopia – this had some bearing on the methodology.
Capture method	Measurements and tests
Collection Period	From To 12 July 2006 1 January 2014
Date	2 March 2022
Geographical area covered (offline during plugin upgrade)	North East South West -15.4683 35.408 -15.9673 34.8147
Language(s) of written materials	English
Creator(s)	Kerac, M ; Anujuo, K ; Lelijveld, N ; Kanjala, C ; Chimwezi, E and Nyirenda, M
Associated roles	Kerac, M (Principal Investigator); Anujuo, K (Project Manager); Lelijveld, N (Co-Investigator); Kanjala, C (Co-Investigator); Chimwezi, E (Other) and Nyirenda, M (Co-Investigator)
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre	Maternal and Child Health Intervention Research Group
Research Group	Nutrition
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi
Funders	Project Funder Grant Number Funder URI Chronic Disease Outcome following Severe Acute Malnutrition (ChroSAM study) Wellcome Trust 101113/Z/13/A) https://doi.org/10.13039/100010269 CHild malnutrition & Adult NCDs: Generating new Evidence on mechanistic links to inform future policy and practice (CHANGE project) Medical Research Council MR/V000802/1 https://doi.org/10.13039/501100000265
Date Deposited	03 Mar 2022 17:31
Last Modified	09 Oct 2025 15:11
Publisher	London School of Hygiene & Tropical Medicine

Explore Further

Dept of Population Health (2012- )

Maternal and Child Health Intervention Research Group

Data / Code

ChroSAM_CHANGE_dataset.txt

subject: Data
lock: Restricted to Request access for all
copyright: Available under Data Sharing Agreement
info: Access arrangements for the ChroSAM CHANGE dataset are handled in-country by the study investigators, in accordance with study ethics approvals. Please consult the data codebook for information
description: text/plain
folder_info: 970B

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Documentation

ChroSAM_CHANGE_codebook.html

subject: Documentation
: Available under Creative Commons: Attribution 4.0
info: CHANGE Cohort 2: Chronic disease outcomes after Severe Acute Malnutrition (ChroSAM). Malawi – User Guide and Codebook
html: text/html
folder_info: 23kB

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