Davies, NG, Jarvis, CI, CMMID COVID-19 Working Group, Edmunds, WJ, Jewell, NP, Diaz-Ordaz, K and Keogh, RH. 2021. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7. [Online]. Zenodo. Available from: https://doi.org/10.5281/zenodo.4579856
Davies, NG, Jarvis, CI, CMMID COVID-19 Working Group, Edmunds, WJ, Jewell, NP, Diaz-Ordaz, K and Keogh, RH. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7 [Internet]. Zenodo; 2021. Available from: https://doi.org/10.5281/zenodo.4579856
Davies, NG, Jarvis, CI, CMMID COVID-19 Working Group, Edmunds, WJ, Jewell, NP, Diaz-Ordaz, K and Keogh, RH (2021). Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7. [Data Collection]. Zenodo. https://doi.org/10.5281/zenodo.4579856
Description
Analysis code and data for: "Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7". SARS-CoV-2 lineage B.1.1.7, a variant first detected in the United Kingdom in September 2020, has spread to multiple countries worldwide. Several studies have established that B.1.1.7 is more transmissible than preexisting variants, but have not identified whether it leads to any change in disease severity. We analyse a dataset linking 2,245,263 SARS-CoV-2 community tests and 17,452 COVID-19 deaths in England from 1 September 2020 to 14 February 2021. For 1,146,534 (51%) of these tests, the presence or absence of B.1.1.7 can be identified because of mutations in this lineage preventing PCR amplification of the spike gene target (S gene target failure, SGTF). Based on 4,945 deaths with known SGTF status, we estimate that the hazard of death associated with SGTF is 55% (95% CI 39–72%) higher after adjustment for age, sex, ethnicity, deprivation, care home residence, local authority of residence and test date. This corresponds to the absolute risk of death for a 55–69-year-old male increasing from 0.6% to 0.9% (95% CI 0.8–1.0%) within 28 days after a positive test in the community. Correcting for misclassification of SGTF and missingness in SGTF status, we estimate a 61% (42–82%) higher hazard of death associated with B.1.1.7. Our analysis suggests that B.1.1.7 is not only more transmissible than preexisting SARS-CoV-2 variants, but may also cause more severe illness.
Keywords
Data capture method | Unknown |
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Date (Date published in a 3rd party system) | 4 March 2021 |
Language(s) of written materials | English |
Data Creators | Davies, NG, Jarvis, CI, CMMID COVID-19 Working Group, Edmunds, WJ, Jewell, NP, Diaz-Ordaz, K and Keogh, RH |
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LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Medical Statistics |
Research Centre | Centre for Statistical Methodology Centre for the Mathematical Modelling of Infectious Diseases |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 09 Mar 2021 12:07 |
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Last Modified | 16 Jul 2021 10:17 |
Publisher | Zenodo |