Loa loa Alben Trial data
Loiasis is a parasitic infection endemic in the African rain forest caused by the filarial nematode Loa loa. Loiasis can be co-endemic with onchocerciasis and/or lymphatic filariasis. Ivermectin, the drug used in the control of these diseases, can induce serious adverse reactions in patients with high L loa microfilaraemia (LLM). A drug is needed which can lower LLM below the level that represents a risk so that ivermectin mass treatment to support onchocerciasis and lymphatic filariasis elimination can be implemented safely. Sixty men and women from a loiasis endemic area in Cameroon were randomized after stratification by screening LLM (≤30000, 30001-50000, >50000) to three treatment arms: two doses albendazole followed by 4 doses matching placebo (n = 20), six doses albendazole (n = 20) albendazole or 6 doses matching placebo (n = 20) administered every two months. LLM was measured before each treatment and 14, 18, 21 and 24 months after the first treatment. Monitoring for adverse events occurred three and seven days as well as 2 months after each treatment. None of the adverse events recorded were considered treatment related. The percentages of participants with ≥ 50% decrease in LLM from pre-treatment for ≥ 4 months were 53%, 17% and 11% in the 6-dose, 2-dose and placebo treatment arms, respectively. The difference between the 6-dose and the placebo arm was significant (p = 0.01). The percentages of participants with LLM < 8100 mf/ml for ≥4 months were 21%, 11% and 0% in the 6-dose, 2-dose and placebo treatment arms, respectively. The 6-dose regimen reduced LLM significantly, but the reduction was insufficient to eliminate the risk of severe and/or serious adverse reactions during ivermectin mass drug administration in loiasis co-endemic areas.
Keywords
Loa loa, Adverse events, Loiasis, Onchocerciasis, Adverse reactions, Drug therapy, Onchocerca volvulus, Lymphatic filariasisItem Type | Dataset |
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Capture method | Experiment: Field Intervention |
Collection Period |
From To January 2007 March 2007 |
Date | 11 March 2016 |
Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude 2.95285 11.938 2.71145 11.1429 |
Language(s) of written materials | English |
Creator(s) |
Lammie, PJ, Kamgno, J, Nguipdop-Djomo, P |
LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) |
Participating Institutions | London School of Hygiene & Tropical Medicine, University of Yaoundé, Centre Pasteur du Cameroun |
Funders |
Project Funder Grant Number Funder URI |
Date Deposited | 23 Mar 2016 10:32 |
Last Modified | 08 Jul 2021 12:49 |
Publisher | PLOS Neglected Tropical Diseases |
Explore Further
- GlaxoSmithKline
- The World Bank
- Bill and Melinda Gates Foundation
- UNICEF
- United Nations Development Programme
- World Health Organization
- Data record - Figshare (Data)
- Data download - Figshare (Online Data Resource)
- 10.1371/journal.pntd.0004492.s002 (DOI)
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subject - Documentation
- Creative Commons: Attribution-No Derivative Works
- Available under Creative Commons: Attribution-No Derivative Works 3.0
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info - Protocol of the trial with amendment
picture_as_pdf - application/pdf
- folder_info
- 591kB