Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi

Kanjala, C, Glynn, JR and Fine, P. 2020. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00001872.

Kanjala, C, Glynn, JR and Fine, P. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi [Internet]. London School of Hygiene & Tropical Medicine; 2020. Available from: https://doi.org/10.17037/DATA.00001872.

Kanjala, C, Glynn, JR and Fine, P (2020). Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00001872.

Description

Additional information

Description of data capture Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Active follow-up was carried out in northern areas of the district in 1991-94 and in a southern area in 2002-2018 covering 15.8% (7389 individuals) and 12.0% (5616 individuals) of the trial population respectively. Year of death or leaving the area were recorded for those not found. The original trial is described in detail in: [1] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. [2] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [3] Fine P. Does giving a second BCG vaccination or adding a leprosy vaccine to BCG vaccination provide additional protection against leprosy and tuberculosis, compared with giving a single BCG vaccination? 2019. http://www.isrctn.com/ISRCTN11311670
Data capture method Questionnaire
Data Collection Period
FromTo
19862018
Date (Date submitted to LSHTM repository) 25 September 2020
Geographical area covered (offline during plugin upgrade)
North LatitudeEast LongitudeSouth LatitudeWest Longitude
-9.9297933.9724-10.021833.8611
Language(s) of written materials English
Data Creators Kanjala, C, Glynn, JR and Fine, P
Associated roles Crampin, AC (Project Leader)
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Participating Institutions London School of Hygiene & Tropical Medicine, London, United Kingom
Funders
ProjectFunderGrant NumberFunder URI
Karonga Prevention StudyBritish Leprosy Relief AssociationUNSPECIFIEDUNSPECIFIED
Karonga Prevention StudyInternational Federation of Anti-Leprosy OrganizationsUNSPECIFIEDUNSPECIFIED
Karonga Prevention StudyUNDP/World Bank/WHO Special Programme for Research and Training in Tropical DiseasesUNSPECIFIEDUNSPECIFIED
Date Deposited 25 Sep 2020 15:42
Last Modified 26 Nov 2021 14:17
Publisher London School of Hygiene & Tropical Medicine

Share

Downloads

Data not available from this repository.

Downloads

View details

Metrics & Citations

Google Scholar