Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi
Kanjala, C
, Glynn, JR and Fine, P
(2020).
Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00001872.
, Glynn, JR and Fine, P
(2020).
Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00001872.
Individual level data on vaccine allocation and outcome (dates of death or loss to follow-up) in those actively followed in two areas following the original vaccine trial in 1986-89.
Additional Information
The dataset and accompanying document for this submission are currently being prepared and will be made available at a later date.
Keywords
Bacillus Calmette–Guérin; Mortality; BCG non-specific effects| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Active follow-up was carried out in northern areas of the district in 1991-94 and in a southern area in 2002-2018 covering 15.8% (7389 individuals) and 12.0% (5616 individuals) of the trial population respectively. Year of death or leaving the area were recorded for those not found. The original trial is described in detail in: [1] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. [2] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [3] Fine P. Does giving a second BCG vaccination or adding a leprosy vaccine to BCG vaccination provide additional protection against leprosy and tuberculosis, compared with giving a single BCG vaccination? 2019. http://www.isrctn.com/ISRCTN11311670 |
| Capture method | Questionnaire |
| Collection Period |
From To 1986 2018 |
| Date | 25 September 2020 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -9.92979 33.9724 -10.0218 33.8611 |
| Language(s) of written materials | English |
| Creator(s) |
Kanjala, C, Glynn, JR and Fine, P
|
| Associated roles | Crampin, AC (Project Leader) |
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingom |
| Funders |
Project Funder Grant Number Funder URI Karonga Prevention Study UNSPECIFIED UNSPECIFIED Karonga Prevention Study UNSPECIFIED UNSPECIFIED |
| Date Deposited | 25 Sep 2020 15:42 |
| Last Modified | 26 Nov 2021 14:17 |
| Publisher | London School of Hygiene & Tropical Medicine |
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