Kanjala, C, Glynn, JR and Fine, P. 2020. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00001872.
Kanjala, C, Glynn, JR and Fine, P. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi [Internet]. London School of Hygiene & Tropical Medicine; 2020. Available from: https://doi.org/10.17037/DATA.00001872.
Kanjala, C, Glynn, JR and Fine, P (2020). Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00001872.
Description
Individual level data on vaccine allocation and outcome (dates of death or loss to follow-up) in those actively followed in two areas following the original vaccine trial in 1986-89.
Additional information
The dataset and accompanying document for this submission are currently being prepared and will be made available at a later date.
| Description of data capture | Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Active follow-up was carried out in northern areas of the district in 1991-94 and in a southern area in 2002-2018 covering 15.8% (7389 individuals) and 12.0% (5616 individuals) of the trial population respectively. Year of death or leaving the area were recorded for those not found. The original trial is described in detail in: [1] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. [2] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [3] Fine P. Does giving a second BCG vaccination or adding a leprosy vaccine to BCG vaccination provide additional protection against leprosy and tuberculosis, compared with giving a single BCG vaccination? 2019. http://www.isrctn.com/ISRCTN11311670 | ||||||||
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| Data capture method | Questionnaire | ||||||||
| Data Collection Period |
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| Date (Completed) | 25 September 2020 | ||||||||
| Geographical area covered |
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| Language(s) of written materials | English |
| Data Creators | Kanjala, C, Glynn, JR and Fine, P |
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| Associated roles | Crampin, AC (Project Leader) |
| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingom |
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| Date Deposited | 25 Sep 2020 15:42 |
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| Last Modified | 26 Nov 2021 14:17 |
| Publisher | London School of Hygiene & Tropical Medicine |
