Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)

Torres, AG; Vidal, RM; Muhsen, K; Tennant, SM; Svennerholm, A; Sow, SO; Sur, D; Zaidi, AKM; Faruque, ASG; Saha, D; Adegbola, R; Hossain, MJ; Alonso, PL; Breiman, RF; Bassat, Q; Tamboura, B; Sanogo, D; Onwuchekwa, U; Manna, B; Ramamurthy, T; Kanungo, S; Ahmed, S; Qureshi, S; Quadri, F; Hossain, A; Das, SK; Antonio, M; Mandomando, I; Nhampossa, T; Acácio, S; Omore, R; Ochieng, JB; Oundo, JO; Mintz, ED; O’Reilly, CE; Berkeley, LY; Livio, S; Panchalingam, S; Nasrin, D; Farag, TH; Wu, Y; Sommerfelt, H; Robins-Browne, RM; Del Canto, F; Hazen, TH; Rasko, DA; Kotloff, KL; Nataro, JP and Levine, MM (2019). Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS). [Dataset]. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0007037

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Enterotoxigenic Escherichia coli (ETEC) encoding heat-stable enterotoxin (ST) alone or with heat-labile enterotoxin (LT) cause moderate-to-severe diarrhea (MSD) in developing country children. The Global Enteric Multicenter Study (GEMS) identified ETEC encoding ST among the top four enteropathogens. Since the GEMS objective was to provide evidence to guide development and implementation of enteric vaccines and other interventions to diminish diarrheal disease morbidity and mortality, we examined colonization factor (CF) prevalence among ETEC isolates from children age <5 years with MSD and from matched controls in four African and three Asian sites. We also assessed strength of association of specific CFs with MSD.

Keywords

Enterotoxigenic Escherichia coli; Diarrhea

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Unknown
Date	4 January 2019
Language(s) of written materials	English
Creator(s)	Torres, AG; Vidal, RM; Muhsen, K; Tennant, SM; Svennerholm, A; Sow, SO; Sur, D; Zaidi, AKM; Faruque, ASG; Saha, D; Adegbola, R; Hossain, MJ; Alonso, PL; Breiman, RF; Bassat, Q; Tamboura, B; Sanogo, D; Onwuchekwa, U; Manna, B; Ramamurthy, T; Kanungo, S; Ahmed, S; Qureshi, S; Quadri, F; Hossain, A; Das, SK; Antonio, M; Mandomando, I; Nhampossa, T; Acácio, S; Omore, R; Ochieng, JB; Oundo, JO; Mintz, ED; O’Reilly, CE; Berkeley, LY; Livio, S; Panchalingam, S; Nasrin, D; Farag, TH; Wu, Y; Sommerfelt, H; Robins-Browne, RM; Del Canto, F; Hazen, TH; Rasko, DA; Kotloff, KL; Nataro, JP and Levine, MM
LSHTM Faculty/Department	MRC Unit The Gambia at LSHTM
Participating Institutions	MRC Unit The Gambia at LSHTM
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Bill and Melinda Gates Foundation 38874 and 38874.01 http://dx.doi.org/10.13039/100000865
Date Deposited	21 Jan 2020 16:13
Last Modified	17 Feb 2026 16:43
Publisher	PLoS Neglected Tropical Diseases