Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

Slater, HC, Ross, A, Felger, I, Hofmann, NE, Robinson, L, Cook, JORCID logo, Gonçalves, BPORCID logo, Björkman, A, Ouedraogo, AL, Morris, U, Msellem, M, Koepfli, C, Mueller, I, Tadesse, F, Gadisa, E, Domingo, G, Kapulu, M, Midega, J, Owusu-Agyei, S, Nabet, C, Piarroux, R, Doumbo, O, Doumbo, SN, Koram, K, Lucchi, N, Udhayakumar, V, Mosha, J, Tiono, A, Chandramohan, DORCID logo, Gosling, R, Mwingira, F, Sauerwein, R, Riley, EMORCID logo, White, NJ, Nosten, F, Imwong, M, Bousema, T, Drakeley, CORCID logo and Okell, LC (2019). Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density. [Dataset]. Dryad. https://doi.org/10.5061/dryad.75t5382
Copy

Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.

Keywords

infections, infectivity, malaria, malaria submicroscopic infections infectivity, submicroscopic

No files available. Please consult associated links.


Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core (with Type as Type) MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON METS MODS RDF+N3 RDF+N-Triples RDF+XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads