Slater, HC, Ross, A, Felger, I, Hofmann, NE, Robinson, L, Cook, J, Gonçalves, BP, Björkman, A, Ouedraogo, AL, Morris, U, Msellem, M, Koepfli, C, Mueller, I, Tadesse, F, Gadisa, E, Domingo, G, Kapulu, M, Midega, J, Owusu-Agyei, S, Nabet, C, Piarroux, R, Doumbo, O, Doumbo, SN, Koram, K, Lucchi, N, Udhayakumar, V, Mosha, J, Tiono, A, Chandramohan, D, Gosling, R, Mwingira, F, Sauerwein, R, Riley, EM, White, NJ, Nosten, F, Imwong, M, Bousema, T, Drakeley, C and Okell, LC. 2019. Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density. [Online]. Dryad. Available from: https://doi.org/10.5061/dryad.75t5382
Slater, HC, Ross, A, Felger, I, Hofmann, NE, Robinson, L, Cook, J, Gonçalves, BP, Björkman, A, Ouedraogo, AL, Morris, U, Msellem, M, Koepfli, C, Mueller, I, Tadesse, F, Gadisa, E, Domingo, G, Kapulu, M, Midega, J, Owusu-Agyei, S, Nabet, C, Piarroux, R, Doumbo, O, Doumbo, SN, Koram, K, Lucchi, N, Udhayakumar, V, Mosha, J, Tiono, A, Chandramohan, D, Gosling, R, Mwingira, F, Sauerwein, R, Riley, EM, White, NJ, Nosten, F, Imwong, M, Bousema, T, Drakeley, C and Okell, LC. Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density [Internet]. Dryad; 2019. Available from: https://doi.org/10.5061/dryad.75t5382
Slater, HC, Ross, A, Felger, I, Hofmann, NE, Robinson, L, Cook, J, Gonçalves, BP, Björkman, A, Ouedraogo, AL, Morris, U, Msellem, M, Koepfli, C, Mueller, I, Tadesse, F, Gadisa, E, Domingo, G, Kapulu, M, Midega, J, Owusu-Agyei, S, Nabet, C, Piarroux, R, Doumbo, O, Doumbo, SN, Koram, K, Lucchi, N, Udhayakumar, V, Mosha, J, Tiono, A, Chandramohan, D, Gosling, R, Mwingira, F, Sauerwein, R, Riley, EM, White, NJ, Nosten, F, Imwong, M, Bousema, T, Drakeley, C and Okell, LC (2019). Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density. [Data Collection]. Dryad. https://doi.org/10.5061/dryad.75t5382
Description
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
| Data capture method | Unknown |
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| Date (Published in a 3rd party system) | 6 May 2019 |
| Language(s) of written materials | English |
| Data Creators | Slater, HC, Ross, A, Felger, I, Hofmann, NE, Robinson, L, Cook, J, Gonçalves, BP, Björkman, A, Ouedraogo, AL, Morris, U, Msellem, M, Koepfli, C, Mueller, I, Tadesse, F, Gadisa, E, Domingo, G, Kapulu, M, Midega, J, Owusu-Agyei, S, Nabet, C, Piarroux, R, Doumbo, O, Doumbo, SN, Koram, K, Lucchi, N, Udhayakumar, V, Mosha, J, Tiono, A, Chandramohan, D, Gosling, R, Mwingira, F, Sauerwein, R, Riley, EM, White, NJ, Nosten, F, Imwong, M, Bousema, T, Drakeley, C and Okell, LC |
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| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 09 May 2022 13:44 |
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| Last Modified | 09 May 2022 13:44 |
| Publisher | Dryad |
