Radiologically-confirmed pneumonia (RCP) is a specific end-point used in trials of Pneumococcal Conjugate Vaccine (PCV) to estimate vaccine efficacy. The dataset is for a study which was set up to ascertain repeatability and reliability of paediatric chest radiographs(CXR) interpretation using percent agreement and Cohen’s kappa in a study of the impact of PCV on pneumonia. The study was conducted in Kilifi County Hospital(KCH) between April 2006 and March 2014. All children aged ≥2 months to <12 years who were admitted to KCH and residents of Kilifi Health and Demographic Surveillance System (KHDSS) were eligible for the study. Radiographs were obtained from 2,716 children admitted with clinically defined severe or very-severe pneumonia. The images were randomly grouped into batches of approximately 100 images each. To assess repeatability, a 5% random sample was presented twice. All the images were read once by two local primary readers. Discordant readings and 13% of concordant readings were arbitrated by a panel of three expert radiologists. The images were read between January 2013 and October 2014. The findings were that Intra- and inter-observer agreements on interpretations of RCP are moderately good to high. Good sensitivity and high specificity make RCP, determined in the field, a suitable endpoint to evaluate vaccine effectiveness.

Access to the dataset is restricted as it contains sensitive information on participants. Accompanying documentation is available under open access. For more detailed information beyond the metadata and documentation provided, there is a process of managed access requiring submission of a request form for consideration by our Data Governance Committee.

Paediatric chest radiographs