Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR. 2019. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Online]. Nature Communications. Available from: https://doi.org/10.1038/s41467-019-08794-x
Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory [Internet]. Nature Communications; 2019. Available from: https://doi.org/10.1038/s41467-019-08794-x
Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR (2019). Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Data Collection]. Nature Communications. https://doi.org/10.1038/s41467-019-08794-x
Description
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.
Keywords
Data capture method | Aggregation |
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Date (Date published in a 3rd party system) | 12 March 2019 |
Language(s) of written materials | English |
Data Creators | Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR |
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LSHTM Faculty/Department | MRC Unit The Gambia at LSHTM |
Participating Institutions | Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia |
Date Deposited | 15 Mar 2019 13:33 |
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Last Modified | 08 Jul 2021 12:50 |
Publisher | Nature Communications |