Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, BORCID logo, Levy, O and Kollmann, TR (2019). Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Dataset]. Nature Communications. https://doi.org/10.1038/s41467-019-08794-x
Copy

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.

Keywords

Systems biology; Newborn

No files available. Please consult associated links.


Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core (with Type as Type) MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON METS MODS RDF+N3 RDF+N-Triples RDF+XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export