Targeted Amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity in Kilifi, KENYA
Wamae, K
, Ndwiga, L, Kharabora, O, Kimenyi, KM, Osoti, V, de Laurent, ZR, Wambua, J, Musyoki, J, Ngetsa, C, Kalume, P, Mwambingu, G, Hamaluba, M, van der Pluijm, RW, Dondorp, AM, Bailey, JA, Juliano, JJ, Bejon, P and Ochola-Oyier, LI
(2022).
Targeted Amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity in Kilifi, KENYA.
[Dataset].
Zenodo.
https://doi.org/10.5281/zenodo.6243928
, Ndwiga, L, Kharabora, O, Kimenyi, KM, Osoti, V, de Laurent, ZR, Wambua, J, Musyoki, J, Ngetsa, C, Kalume, P, Mwambingu, G, Hamaluba, M, van der Pluijm, RW, Dondorp, AM, Bailey, JA, Juliano, JJ, Bejon, P and Ochola-Oyier, LI
(2022).
Targeted Amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity in Kilifi, KENYA.
[Dataset].
Zenodo.
https://doi.org/10.5281/zenodo.6243928
These data were generated from targeted amplicon sequencing of Plasmodium falciparum ama1 and mdr1 genes in samples collected from Kilifi, at the coast of Kenya.
Two objectives were explored:
[1] To determine temporal changes in the genetic diversity of malaria parasites in asymptomatic and febrile infections.
[2] To track within-host parasite diversity, throughout treatment in a clinical drug trial.
Keywords
next generation sequencing, targeted amplicon sequencing, deep sequencing, malaria, asymptomatic infections, antimalarial drug trial| Item Type | Dataset |
|---|---|
| Capture method | Unknown |
| Date | 23 February 2022 |
| Language(s) of written materials | English |
| Creator(s) |
Wamae, K, Ndwiga, L, Kharabora, O, Kimenyi, KM, Osoti, V, de Laurent, ZR, Wambua, J, Musyoki, J, Ngetsa, C, Kalume, P, Mwambingu, G, Hamaluba, M, van der Pluijm, RW, Dondorp, AM, Bailey, JA, Juliano, JJ, Bejon, P and Ochola-Oyier, LI
|
| Associated roles | Ochola-Oyier, LI (Supervisor), Bejon, P (Supervisor) and Sutherland, CJ (Supervisor) |
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 28 Feb 2022 11:55 |
| Last Modified | 28 Feb 2022 11:55 |
| Publisher | Zenodo |
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