Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Fletcher, HA

; Keyser, A; Bowmaker, M; Sayles, P; Kaplan, G; Hussey, G; Hill, A and Hanekom, W (2009). Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. [Dataset]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14408

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Transcpripts upregulated by both BCG and PPD were identified in 5 infants and pathway analysis and gene ontology were performed using differentially expressed genes. In this study the frozen PBMC of 5 infants were thawed and stimulated for 12 hours with either BCG or PPD or rested in media alone for 12 hours. The transcripts from the unstimulated PBMC were compared to the PPD and BCG induced transcripts.

Keywords

Response to antigen stimulation

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Experiment: Field Intervention
Date	24 February 2009
Language(s) of written materials	English
Creator(s)	Fletcher, HA ; Keyser, A; Bowmaker, M; Sayles, P; Kaplan, G; Hussey, G; Hill, A and Hanekom, W
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019)
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Date Deposited	11 Jan 2019 10:01
Last Modified	08 Jul 2021 12:49
Publisher	NCBI Gene Expression Omnibus