Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis

Tabular data associated with a comparative Transcriptome analysis of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis. This includes details of primers used for RTqPCR TLDA Experiment; demographic, clinical, and microbiological data for microarray participants; a list of differentially expressed genes, fold changes, and false-discovery rate (FDR) adjusted p-values in the three microarray pairwise comparisons (FK vs. C, BK vs. C, and BK vs. FK); gene ontology enrichment analysis for the differentially expressed genes common to both bacterial and fungal keratitis: biological process (BP_FAT), molecular function (MF_FAT), and cellular component (CC_FAT) terms from DAVID v6.8; gene ontology term enrichment analysis for each of the seven most highly connected gene clusters in the network co-expression analysis (using DAVID v6.8). Normalized expression intensities of all differentially expressed genes in the bacterial and fungal keratitis vs. control comparisons used to create network graph in Miru).; and a comparison of early stage samples from the validation cohort (symptom duration ≤7 days) with microarray tissue samples.

Keywords