Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi

Kanjala, C, Glynn, JR and Fine, P. 2020. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00001872.

Kanjala, C, Glynn, JR and Fine, P. Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Internet] LSHTM Data Compass. London, United Kingdom: London School of Hygiene & Tropical Medicine; 2020. Available from: https://doi.org/10.17037/DATA.00001872.

Kanjala, C, Glynn, JR and Fine, P (2020). Effect of repeat BCG on all-cause mortality: a double-blind randomised placebe-controlled trial in Malawi. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00001872.

Description

Additional information

Description of data capture Individuals age 3 months to 75 years were recruited in house-to-house surveys in 1986-89 in Karonga District, northern Malawi. Those with a BCG scar were randomised to receive repeat BCG or placebo. Active follow-up was carried out in northern areas of the district in 1991-94 and in a southern area in 2002-2018 covering 15.8% (7389 individuals) and 12.0% (5616 individuals) of the trial population respectively. Year of death or leaving the area were recorded for those not found. The original trial is described in detail in: [1] Karonga Prevention Trial Group. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Lancet 1996; 348: 17-24. [2] Ponnighaus JM, Fine PEM, Bliss L, et al. The Karonga Prevention Trial: A leprosy and tuberculosis vaccine trial in Northern Malawi - I: Methods of the vaccination phase. Lepr Rev 1993; 64: 338-56. [3] Fine P. Does giving a second BCG vaccination or adding a leprosy vaccine to BCG vaccination provide additional protection against leprosy and tuberculosis, compared with giving a single BCG vaccination? 2019. http://www.isrctn.com/ISRCTN11311670
Data capture method Questionnaire
Data Collection Period
FromTo
19862018
Date (Completed) 25 September 2020
Geographical area covered
North LatitudeEast LongitudeSouth LatitudeWest Longitude
-9.9297933.9724-10.021833.8611
Language(s) of written materials English
Data Creators Kanjala, C, Glynn, JR and Fine, P
Associated roles Crampin, AC (Project Leader)
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Participating Institutions London School of Hygiene & Tropical Medicine, London, United Kingom
Funders
ProjectFunderGrant NumberFunder URI
Karonga Prevention StudyBritish Leprosy Relief AssociationUNSPECIFIEDUNSPECIFIED
Karonga Prevention StudyInternational Federation of Anti-Leprosy OrganizationsUNSPECIFIEDUNSPECIFIED
Karonga Prevention StudyUNDP/World Bank/WHO Special Programme for Research and Training in Tropical DiseasesUNSPECIFIEDUNSPECIFIED
Depositor Gareth Knight
Date Deposited 25 Sep 2020 15:42
Last Modified 29 Sep 2020 10:37
Publisher London School of Hygiene & Tropical Medicine

Share

Downloads

Data not available from this repository.

Downloads

View details

Metrics & Citations

Google Scholar