Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR. 2019. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Online]. Nature Communications. Available from: https://doi.org/10.1038/s41467-019-08794-x

Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Internet] LSHTM Data Compass. Nature Communications; 2019. Available from: https://doi.org/10.1038/s41467-019-08794-x

Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR (2019). Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. [Data Collection]. Nature Communications. https://doi.org/10.1038/s41467-019-08794-x

Description

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.

Methods

Data capture method	Aggregation
Date (Published in a 3rd party system)	12 March 2019
Language(s) of written materials	English

People & Groups

Data Creators	Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B, Levy, O and Kollmann, TR
LSHTM Faculty/Department	MRC Unit The Gambia at LSHTM
Participating Institutions	Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia