Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.
Keywords
Systems biology, NewbornItem Type | Dataset |
---|---|
Capture method | Aggregation |
Date | 12 March 2019 |
Language(s) of written materials | English |
Creator(s) |
Lee, AH, Shannon, CP, Amenyogbe, N, Bennike, TB, Diray-Arce, J, Idoko, OT, Gill, EE, Ben-Othman, R, Pomat, WS, van Haren, SD, Cao, KL, Cox, M, Darboe, A, Falsafi, R, Ferrari, D, Harbeson, DJ, He, D, Bing, C, Hinshaw, SJ, Ndure, J, Njie-jobe, J, Pettengill, MA, Richmond, PC, Ford, R, Saleu, G, Masiria, G, Matlam, JP, Kirarock, W, Roberts, EHW, Malek, M, Sanchez-Schmitz, G, Singh, A, Angelidou, A, Smolen, KK, Brinkman, RR, Ozonoff, A, Hancock, REW, van den Biggelaar, AHJ, Steen, H, Tebbutt, SJ, Kampmann, B |
LSHTM Faculty/Department | MRC Unit The Gambia at LSHTM |
Participating Institutions | Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia |
Date Deposited | 15 Mar 2019 13:33 |
Last Modified | 08 Jul 2021 12:50 |
Publisher | Nature Communications |
Explore Further
- Idoko, Olubukola T.
- Cox, Momodou
- Darboe, Alansana
- Ndure, Jorjoh
- Njie-jobe, Jainaba
- Roberts, Elishia Hannah Willietta
- Kampmann, Beate
- NCBI GEO Accession GSE111404 (Data)
- NCBI GEO Accession GSE123070 (Data)
- IMMPort (accession numbers SDY1256 and SDY1412) (Data)
- Nature Communications (Online Data Resource)
No files available. Please consult associated links.
- NCBI GEO Accession GSE111404 (Data)
- NCBI GEO Accession GSE123070 (Data)
- IMMPort (accession numbers SDY1256 and SDY1412) (Data)
- Nature Communications (Online Data Resource)