Dhaka household cholera dataset

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Domman, D, Chowdhury, F, Khan, AI, Dorman, MJ, Mutreja, A, Uddin, MI, Paul, A, Begum, YA, Charles, RC, Calderwood, SB, Bhuiyan, TR, Harris, JB, LaRocque, RC, Ryan, ET, Qadri, F and Thomson, NR. 2018. Dhaka household cholera dataset. [Online]. Figshare. Available from: - https://doi.org/10.6084/m9.figshare.6062804.v1

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Although much focus is placed on cholera epidemics, the greatest burden occurs in settings in which cholera is endemic, including areas of South Asia, Africa and now Haiti1,2. Dhaka, Bangladesh is a megacity that is hyper-endemic for cholera, and experiences two regular seasonal outbreaks of cholera each year3. Despite this, a detailed understanding of the diversity of Vibrio cholerae strains circulating in this setting, and their relationships to annual outbreaks, has not yet been obtained. Here we performed whole-genome sequencing of V. cholerae across several levels of focus and scale, at the maximum possible resolution. We analyzed bacterial isolates to define cholera dynamics at multiple levels, ranging from infection within individuals, to disease dynamics at the household level, to regional and intercontinental cholera transmission. Our analyses provide a genomic framework for understanding cholera diversity and transmission in an endemic setting.

Published in a 3rd party system Date: 6 June 2018
Data capture method:
Mode of data capture
Experiment: Field Intervention
Data Creators(s): Domman, D, Chowdhury, F, Khan, AI, Dorman, MJ, Mutreja, A, Uddin, MI, Paul, A, Begum, YA, Charles, RC, Calderwood, SB, Bhuiyan, TR, Harris, JB, LaRocque, RC, Ryan, ET, Qadri, F and Thomson, NR
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom

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