Results of pathway enrichment analysis using Database for Annotation, Visualization and Integrated Discovery (DAVID)

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Roberts, CH, Ouburg, S, Preston, MD, de Vries, HJC, Holland, MJ and Morré, SA. 2018. Results of pathway enrichment analysis using Database for Annotation, Visualization and Integrated Discovery (DAVID). [Online]. Mediators of Inflammation. Available from: 10.1155/2018/3434101 https://www.hindawi.com/journals/mi/2018/3434101/#supplementary-material-1

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Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection and can lead to tubal factor infertility, a disease characterised by fibrosis of the fallopian tubes. Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt/PI3K cascade, the mitotic cell cycle, and immune response have been identified in association with the development of trachomatous scarring, an ocular form of chlamydia-related fibrotic pathology. In this case-control study, we performed genome-wide association and pathways-based analysis in a sample of 71 Dutch women who attended an STI clinic who were seropositive for Chlamydia trachomatis antibodies and 169 high-risk Dutch women who sought similar health services but who were seronegative. We identified two regions of within-gene SNP association with Chlamydia trachomatis serological response and found that GPCR signalling and cell cycle pathways were also associated with the trait. These pathway-level associations appear to be common to immunological sequelae of chlamydial infections in both ocular and urogenital tropisms. These pathways may be central mediators of human refractoriness to chlamydial diseases.

Published in a 3rd party system Date: 3 June 2018
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Data Creators(s): Roberts, CH, Ouburg, S, Preston, MD, de Vries, HJC, Holland, MJ and Morré, SA
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom, VU University Medical Center, 1081 HV Amsterdam, Netherlands, National Institute for Biological Standards and Controls, Potters Bar, UK, United Kingdom, Department of Dermatology Academic Medical Centre, The Netherlands, Maastricht University, 6200 MD Maastricht, Netherlands, Public Health Service of Amsterdam, Amsterdam, Netherlands, University of Amsterdam, Amsterdam, Netherlands

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