Conjunctival transcriptome profiling of Solomon Islanders with active trachoma but without ocular Chlamydia trachomatis infection

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Vasileva, H, Butcher, RMR and Roberts, C. 2018. Conjunctival transcriptome profiling of Solomon Islanders with active trachoma but without ocular Chlamydia trachomatis infection. [Online]. NCBI Gene Expression Omnibus. Available from: - https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE106961

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The prevalence of trachomatous inflammation–follicular (TF) in Solomon Island children aged 1–9 years is high enough to warrant, among other interventions, mass distribution of azithromycin. However, over 90% of those with TF did not have concurrent Chlamydia trachomatis infection. We analysed the transcriptome of children with TF and Ct infection, children diagnosed with TF but no Ct infection and children with neither TF nor Ct infection to better understand host responses during an episode of TF, and investigate whether it can provide any clues about the aetiology of TF in this context.

Published in a 3rd party system Date: 1 March 2018
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Data Creators(s): Vasileva, H, Butcher, RMR and Roberts, C
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom

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