Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

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Stone, WJR, Campo, JJ, Ouédraogo, AL, Meerstein-Kessel, L, Morlais, I, Da, D, Cohuet, A, Nsango, S, Sutherland, CJ, van de Vegte-Bolmer, M, Siebelink-Stoter, R, van Gemert, G, Graumans, W, Lanke, K, Shandling, AD, Pablo, JV, Teng, AA, Jones, S, de Jong, RM, Fabra-García, A, Bradley, J, Roeffen, W, Lasonder, E, Gremo, G, Schwarzer, E, Janse, CJ, Singh, SK, Theisen, M, Felgner, P, Marti, M, Drakeley, C, Sauerwein, R, Bousema, T and Jore, MM. 2018. Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity. [Online]. Dryad Digital Repository. Available from: - https://doi.org/10.5061/dryad.8bp05

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Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.

Published in a 3rd party system Date: 9 February 2018
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Data Creators(s): Stone, WJR, Campo, JJ, Ouédraogo, AL, Meerstein-Kessel, L, Morlais, I, Da, D, Cohuet, A, Nsango, S, Sutherland, CJ, van de Vegte-Bolmer, M, Siebelink-Stoter, R, van Gemert, G, Graumans, W, Lanke, K, Shandling, AD, Pablo, JV, Teng, AA, Jones, S, de Jong, RM, Fabra-García, A, Bradley, J, Roeffen, W, Lasonder, E, Gremo, G, Schwarzer, E, Janse, CJ, Singh, SK, Theisen, M, Felgner, P, Marti, M, Drakeley, C, Sauerwein, R, Bousema, T and Jore, MM
LSHTM Faculty/Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom

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