Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays

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Hensman Moss, DJ, Robertson, N, Farmer, R, Scahill, RI, Haider, S, Tessari, MA, Flynn, G, Fischer, DF, Wild, EJ, Macdonald, D and Tabrizi, SJ. 2017. Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays. [Online]. PLOS One. Available from: - https://doi.org/10.1371/journal.pone.0189891

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Huntington’s disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Optimizing peripheral quantification of huntingtin throughout the course of HD is valuable not only to illuminate the natural history and pathogenesis of disease, but also to detect peripheral effects of drugs in clinical trial.

Published in a 3rd party system Date: 22 December 2017
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Mode of data capture
Experiment: Laboratory
Data Creators(s): Hensman Moss, DJ, Robertson, N, Farmer, R, Scahill, RI, Haider, S, Tessari, MA, Flynn, G, Fischer, DF, Wild, EJ, Macdonald, D and Tabrizi, SJ
LSHTM Faculty/Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Participating Institutions: London School of Hygiene & Tropical Medicine, London, United Kingdom

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