A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt

Manigart, O, Trotter, C, Findlow, H, Assefa, A, Mihret, W, Demisse, TM, Yeshitela, B, Osei, I, Hodgson, A, Quaye, SL, Sow, S, Coulibaly, M, Diallo, K, Traore, A, Collard, J, Boukary, R, Djermakoye, O, Mahamane, AE, Jusot, J, Sokhna, C, Alavo, S, Doucoure, S, Ba, EH, Dieng, M, Diallo, A, Daugla, DM, Omotara, B, Chandramohan, D, Hassan-King, M, Nascimento, M, Woukeu, A, Borrow, R, Stuart, J and Greenwood, B. 2016. A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.34.

Manigart, O, Trotter, C, Findlow, H, Assefa, A, Mihret, W, Demisse, TM, Yeshitela, B, Osei, I, Hodgson, A, Quaye, SL, Sow, S, Coulibaly, M, Diallo, K, Traore, A, Collard, J, Boukary, R, Djermakoye, O, Mahamane, AE, Jusot, J, Sokhna, C, Alavo, S, Doucoure, S, Ba, EH, Dieng, M, Diallo, A, Daugla, DM, Omotara, B, Chandramohan, D, Hassan-King, M, Nascimento, M, Woukeu, A, Borrow, R, Stuart, J and Greenwood, B. A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt [Internet]. London School of Hygiene & Tropical Medicine; 2016. Available from: https://doi.org/10.17037/DATA.34.

Manigart, O, Trotter, C, Findlow, H, Assefa, A, Mihret, W, Demisse, TM, Yeshitela, B, Osei, I, Hodgson, A, Quaye, SL, Sow, S, Coulibaly, M, Diallo, K, Traore, A, Collard, J, Boukary, R, Djermakoye, O, Mahamane, AE, Jusot, J, Sokhna, C, Alavo, S, Doucoure, S, Ba, EH, Dieng, M, Diallo, A, Daugla, DM, Omotara, B, Chandramohan, D, Hassan-King, M, Nascimento, M, Woukeu, A, Borrow, R, Stuart, J and Greenwood, B (2016). A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.34.

Description

The dataset contains results of a cross-sectional survey of meningococcal carriage and immunity performed in several countries of the African meningitis belt in 2010. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was used to measure antibody concentrations in 3930 individuals. Anonymised information on the age, sex, residence, carriage status and other risk factors is included.

Additional information

The survey was performed prior to the introduction of data sharing requirements. Therefore, it was not addressed in the original participant consent form. To fulfill PLOS expectations in this area, the study team sought advice from the LSHTM Ethics Committee in December 2015. Specifically, they requested permission to upload an anonymised dataset to the repository and make it available as request access through a 'gatekeeper'. The LSHTM Ethics Committee approved the request in January 2016, stating that it was in keeping with the intent of the original consent process.

Methods

Description of data capture

Cross-sectional meningococcal carriage surveys were conducted in seven countries across the meningitis belt between July 1st 2010 and December 31st 2010. Subjects were selected randomly from within populations which were part of a routine demographic survey system (DHSS) or in which a census had recently been performed. The study population was recruited from urban and rural populations and stratified into four age groups: < 5 years, 5-14 years, 15-29 years and 30 years or older. A short questionnaire collecting demographic details and information on potential risk factors was completed for each participant and each household recruited. Blood samples were collected from the first 100 subjects surveyed within each of the four age bands in both urban and rural study sites, giving an overall target of 800 samples per country. This target was achieved, except in Senegal where there was some resistance to the collection of blood samples. A 5 mL sample was collected, serum separated within six hours of collection and then stored at -20°C until assayed.

Data capture method

Questionnaire

Data Collection Period

From	To
1 July 2010	31 December 2010

Date (Date submitted to LSHTM repository)

21 January 2016

Geographical area covered (offline during plugin upgrade)

North Latitude	East Longitude	South Latitude	West Longitude
13.7661	45.1318	4.49155	34.8486
21.384	15.4248	13.0822	5.22949
18.4926	3.12012	13.8514	-16.3916
13.1677	14.0186	5.62965	3.73535

Language(s) of written materials

English

People & Groups

Data Creators	Manigart, O, Trotter, C, Findlow, H, Assefa, A, Mihret, W, Demisse, TM, Yeshitela, B, Osei, I, Hodgson, A, Quaye, SL, Sow, S, Coulibaly, M, Diallo, K, Traore, A, Collard, J, Boukary, R, Djermakoye, O, Mahamane, AE, Jusot, J, Sokhna, C, Alavo, S, Doucoure, S, Ba, EH, Dieng, M, Diallo, A, Daugla, DM, Omotara, B, Chandramohan, D, Hassan-King, M, Nascimento, M, Woukeu, A, Borrow, R, Stuart, J and Greenwood, B
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Participating Institutions	London School of Hygiene & Tropical Medicine, University of Cambridge, Public Health England, Armauer Hansen Research Institute, Navrongo Health Research Centre, Centre pour les Vaccins en Développement, Centre de Recherche Médicale et Sanitaire, Institut de Recherche pour le Développement, Centre de Support en Santé International, University of Maiduguri

Projects

Funders

Project	Funder	Grant Number	Funder URI
The African Meningococcal Carriage Consortium (MenAfriCar)	Wellcome Trust	Wellcome Trust 086546/ BMGF OPP51251	UNSPECIFIED
UNSPECIFIED	Bill & Melinda Gates Foundation	UNSPECIFIED	UNSPECIFIED

Additional Information

Date Deposited	27 Jan 2016 12:52
Last Modified	27 Apr 2022 18:19
Publisher	London School of Hygiene & Tropical Medicine

Downloads

Data / Code

MenAfriCar_ELISA_dataset Request access

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Filename: MenAfriCar_ELISA_dataset.zip

Description: Anonymised dataset containing variables on meningococcal carriage status, strain details, commensal Neisseria carriage status, recent vaccination history, serogroup A specific IgG ELISA antibody concentration, and other details.

Licence: Data Sharing Agreement

Content type: Dataset

File size: 114kB

Mime-Type: application/x-zip

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