Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda

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http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/551 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/551 http://eprints.org/relation/issmallThumbnailVersionOf https://datacompass.lshtm.ac.uk/id/document/551 indefinite Thumbnails conversion from Image to thumbnail_small archive 3 disk0/00/00/00/96 2015-11-03 11:19:12 2022-04-27 17:38:33 2015-11-03 11:19:12 data_collection show Lule Swaib Abubaker FALSE Mawa Patrice TRUE 4df067b032e95c30b2aad9f9569cf833 Nkurunungi Gyaviira 0000-0003-4062-9105 TRUE a48ee0eddf888813b8e342fdb4b32087 Nampijja Margaret FALSE Kizito Dennison TRUE 2c9015d61b9e3db7e97d8096dad0dfa9 Akello Florence FALSE Muhangi Lawrence FALSE 2bace95362d3b2d784d396ef5871744d Elliott Alison 0000-0003-2818-9549 TRUE d9d54503b6d617709b2d9f1aaf480651 Webb Emily L FALSE MRC/UVRI Uganda Research Unit on AIDS Entebbe Hospital, Uganda London School of Hygiene & Tropical Medicine Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda ITIM Tuberculosis HIV Helminth Pregnancy Bacille Calmette–Guerin Crude culture filtrate protein BCG is used widely as the sole licensed vaccine against tuberculosis, but it has variable efficacy and the reasons for this are still unclear. No reliable biomarkers to predict future protection against, or acquisition of, TB infection following immunisation have been identified. Lessons from BCG could be valuable in the development of effective tuberculosis vaccines. The Entebbe Mother and Baby Study birth cohort in Uganda investigated factors associated with latent tuberculosis infection (LTBI) and with cytokine response to mycobacterial antigen at age five years. It also investigated whether cytokine responses at one year were associated with LTBI at five years of age. This dataset contains tabular data associated with the analysis 2014-12-19 published Vaccine 10.1016/j.vaccine.2014.12.015 Dataset MRC/UVRI Uganda Research Unit on AIDS Entebbe Hospital, Uganda London School of Hygiene & Tropical Medicine Experiment.FieldIntervention public Wellcome Trust National Institutes of Health GlaxoSmithKline Entebbe Mother and Baby Study Dataset Quantitative Blood samples from age one and five years were stimulated using crude culture filtrates of Mycobacterium tuberculosis in a six-day whole blood assay. IFN-γ, IL-5, IL-13 and IL-10 production was measured. LTBI at five years was determined using T-SPOT.TB® assay. Associations with LTBI at five years were assessed using multivariable logistic regression. Multiple linear regression with bootstrapping was used to determine factors associated with cytokine responses at age five years. The study found that LTBI prevalence was 9% at age five years. Only urban residence and history of TB contact/disease were positively associated with LTBI. BCG vaccine strain, LTBI, HIV infection, asymptomatic malaria, growth z-scores, childhood anthelminthic treatment and maternal BCG scar were associated with cytokine responses at age five. Cytokine responses at one year were not associated with acquisition of LTBI by five years of age. 063693; 079110 0.0968364 32.5115 0.0219492 32.4143 en Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda. http://researchonline.lshtm.ac.uk/id/eprint/2338106 Entebbe Mother and Baby Study Wellcome Trust 063693; 079110 National Institutes of Health GlaxoSmithKline 063693; 079110 2014-12-19