766 75 5339 4 21402 document 5339 Appendix2-dataset.csv text/plain 2389815a6e8ef9b43a45ba479798d74a6a4623eb3c5332a2e23dd3ef58176844 SHA256 126323 2018-07-02 09:41:16 https://datacompass.lshtm.ac.uk/id/eprint/766/1/Appendix2-dataset.csv 766 1 1 text/plain Dataset en public cc_by

Appendix2-dataset.csv

data indefinite Supplementary appendix 2 for dataset 18353 3 103170 document 18353 Data_codebook.html text/html 8f58812cc8539005b8eee8de84bc3a700320c86c2d8b1b20d16f9e55c0a5f903 SHA256 10113 2025-09-18 14:12:28 https://datacompass.lshtm.ac.uk/id/eprint/766/2/Data_codebook.html 766 2 2 text/html Text en public cc_by_4

Data_codebook.html

documentation indefinite Dataset codebook archive 3 disk0/00/00/07/66 2018-07-02 09:22:18 2026-03-19 13:45:35 2018-07-02 09:43:40 data_collection show Marks Michael 0000-0002-7585-4743 TRUE 54eab523b156a17f7e138e8a2b46f316 Mitjà Oriol FALSE Bottomley Christian 0000-0002-5241-8412 TRUE d90d749e9ca29f26bf5ee09965e5f3b9 Kwakye Cynthia FALSE Houinei Wendy FALSE Bauri Mathias FALSE Adwere Paul FALSE Abdulai Abdul A FALSE Dua Fredrick FALSE Boateng Laud FALSE Wangi James FALSE Ohene Sally-Ann FALSE Wangnapi Regina FALSE Simpson Shirley V FALSE Miag Helen FALSE Addo Kennedy K FALSE Basing Laud A FALSE Danavall Damien FALSE Chi Kai H FALSE Pillay Allan FALSE Ballard Ronald FALSE Solomon Anthony W FALSE Chen Cheng Y FALSE Bieb Sibauk V FALSE Adu-Sarkodie Yaw FALSE Mabey David C W 0000-0002-0031-8276 TRUE 28675e0a9d179e9729c0f9454269a749 Asiedu Kingsley FALSE ProjectMember Agana Nsire FALSE ProjectMember Ampadu Edwin FALSE ProjectMember Amponsah-Achiano Kwame FALSE ProjectMember Bediako Asare FALSE ProjectMember Biredu Michael FALSE ProjectMember Faried Kyei FALSE ProjectMember Iddrisu Ahmed FALSE ProjectMember Kotey Nana K FALSE ProjectMember Yeboah George NY FALSE ProjectMember El-Duah Philip FALSE ProjectMember Phillips Richard FALSE ProjectMember Binka Fred FALSE ProjectMember Nyonator Frank FALSE ProjectMember Zunuo Anthony FALSE ProjectMember Ackumey Mercy A FALSE ProjectMember Amanor Ivy FALSE ProjectMember Bnosu Christian FALSE ProjectMember Frischmann Sieghard FALSE ProjectMember Lammie Patrick FALSE ProjectMember Martin Diana FALSE ProjectMember Ye Tun FALSE ProjectMember Christophel Eva FALSE ProjectMember Tiendrebeogo Alexandre FALSE ProjectMember Vestergard Lasse FALSE ProjectMember Bassat Quique FALSE ProjectMember Abdad Yazid FALSE ProjectMember Dima Henson FALSE ProjectMember Kotty Bethuel FALSE ProjectMember Mamore Kaiok FALSE ProjectMember Manup Walerius FALSE ProjectMember Olowau Benson FALSE ProjectMember Agyei Enoch O FALSE ProjectMember Agyemang David FALSE ProjectMember Ako Ebenezer P FALSE ProjectMember Antwi Prince FALSE ProjectMember Darko Jane FALSE ProjectMember Darko Ophelia O FALSE ProjectMember Darko Phylis FALSE ProjectMember Duodu Bertha FALSE ProjectMember Jabasi Daniel FALSE ProjectMember Karim Fuseini L FALSE ProjectMember Koomson Obed K FALSE ProjectMember Labri Bernard A FALSE ProjectMember Nartey John FALSE ProjectMember Tamatey Randsford FALSE ProjectMember Yirenkyi Benjamin FALSE ProjectMember Arhin Mercy FALSE ProjectMember Biney Frank FALSE ProjectMember Danso Juliana O FALSE ProjectMember Dei Martin A FALSE ProjectMember Djan Moses FALSE ProjectMember Sasu Samuel FALSE ProjectMember Solomon Brefo A FALSE ProjectMember Torvinya Victor FALSE ProjectMember Amankwaah Hagar FALSE ProjectMember Baffoe James FALSE ProjectMember Djan Moses FALSE ProjectMember Keteku Lydia FALSE ProjectMember Kondobala Kofi FALSE ProjectMember Lomotey Rita D FALSE ProjectMember Nartey Augustina A FALSE ProjectMember Oppong Paul FALSE ProjectMember Quainoo Millicent A FALSE ProjectMember Abotsi Theophilus FALSE ProjectMember Agebshie Dzighordi FALSE ProjectMember Ameamu Amos FALSE ProjectMember Angwaawie Paul FALSE ProjectMember Ayibor Rose FALSE ProjectMember Mwingmendeli Margaret FALSE ProjectMember Nakodia John FALSE ProjectMember Nambagyira Amatus FALSE ProjectMember Nanga Dominic FALSE ProjectMember Dominic Nichola FALSE ProjectMember Wanaom Augustine FALSE London School of Hygiene & Tropical Medicine, London, United Kingdom World Health Organization Centers for Disease Control and Prevention Kwame Nkrumah University of Science and Technology Barcelona Institute for Global Health Papua New Guinea Institute of Medical Research Ghana Health Services Noguchi Memorial Institute for Medical Research Papua New Guinea National Department of Health University of Health and Allied Sciences, Ho, Volta Region, Ghana EPID ITCR Yaws Active Yaws Latent Yaws Anti-bacterial agents Azithromycin A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. We aimed to determine the efficacy of 20 mg/kg of azithromycin compared with 30 mg/kg azithromycin for the treatment of active and latent yaws. We did a non-inferiority, open-label, randomised controlled trial in children aged 6-15 years who were recruited from schools in Ghana and schools and the community in Papua New Guinea. Participants were enrolled based on the presence of a clinical lesion that was consistent with infectious primary or secondary yaws and a positive rapid diagnostic test for treponemal and non-treponemal antibodies. Participants were randomly assigned (1:1) to receive either standard-dose (30 mg/kg) or low-dose (20 mg/kg) azithromycin by a computer-generated random number sequence. Health-care workers assessing clinical outcomes in the field were not blinded to the patient's treatment, but investigators involved in statistical or laboratory analyses and the participants were blinded to treatment group. We followed up participants at 4 weeks and 6 months. The primary outcome was cure at 6 months, defined as lesion healing at 4 weeks in patients with active yaws and at least a four-fold decrease in rapid plasma reagin titre from baseline to 6 months in patients with active and latent yaws. Active yaws was defined as a skin lesion that was positive for Treponema pallidum ssp pertenue in PCR testing. We used a non-inferiority margin of 10%. This trial was registered with ClinicalTrials.gov, number NCT02344628. Between June 12, 2015, and July 2, 2016, 583 (65·1%) of 895 children screened were enrolled; 292 patients were assigned a low dose of azithromycin and 291 patients were assigned a standard dose of azithromycin. 191 participants had active yaws and 392 had presumed latent yaws. Complete follow-up to 6 months was available for 157 (82·2%) of 191 patients with active yaws. In cases of active yaws, cure was achieved in 61 (80·3%) of 76 patients in the low-dose group and in 68 (84·0%) of 81 patients in the standard-dose group (difference 3·7%; 95% CI -8·4 to 15·7%; this result did not meet the non-inferiority criterion). There were no serious adverse events reported in response to treatment in either group. The most commonly reported adverse event at 4 weeks was gastrointestinal upset, with eight (2·7%) participants in each group reporting this symptom. In this study, low-dose azithromycin did not meet the prespecified non-inferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws. Only a single participant (with presumed latent yaws) had definitive serological failure. This work suggests that 20 mg/kg of azithromycin is probably effective against yaws, but further data are needed. 2018-02-15 published London School of Hygiene & Tropical Medicine 10.17037/DATA.00000766 Dataset Study consortium Experiment.FieldIntervention 148 223 JXK RNPA-AMR RK-DR public London, United Kingdom Coalition for Operational Research on Neglected Tropical Diseases Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Randomized Controlled Trial Comparing Efficacy of Single Dose Treatment of Yaws With 20mg/kg Versus 30mg/kg of Azithromycin Dataset Quantitative Eligible children were randomly assigned to either a low-dose (20 mg/kg, maximum 1 g) or standard-dose (30 mg/kg, maximum 2 g) group. Randomisation was performed in blocks of four, by use of a computer-generated random number sequence that was generated by the trial statistician (CB) at the London School of Hygiene & Tropical Medicine. Allocation was concealed from investigators by use of opaque, sealed, sequentially numbered envelopes that were opened after the study team had enrolled a participant. Health-care workers assessing clinical outcomes in the field were not masked to the patient's treatment group but patients and investigators performing statistical or laboratory analyses of samples were masked to treatment allocation. Study allocations are listed in appendix 2. 8.33822 0.576166 8.20912 0.451197 5.9844 -0.485181 5.78223 -0.751599 en 2015-06-12 2016-07-02 https://clinicaltrials.gov/ct2/show/NCT02344628 other https://doi.org/10.1016/S2214-109X(18)30023-8 paper http://researchonline.lshtm.ac.uk/id/eprint/4646742 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Coalition for Operational Research on Neglected Tropical Diseases Randomized Controlled Trial Comparing Efficacy of Single Dose Treatment of Yaws With 20mg/kg Versus 30mg/kg of Azithromycin 2018-02-15