Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result"

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XPHACTOR_RepeatXpert_substudy_data.zip

data indefinite Unlinked Repeat Xpert dataset - MS Excel and CSV format. Data can be reused for HIV and TB related research only archive 84 disk0/00/00/06/81 2018-04-16 15:33:23 2025-06-02 12:02:40 2018-04-16 15:33:23 data_collection show Hanifa Yasmeen TRUE 3882e45254c93d8b35981d46f7986775 Fielding Katherine 0000-0002-6524-3754 TRUE 0aa3885fd6201076535210a253a38f98 Grant Alison D. 0000-0002-2437-5195 TRUE b0df4f9b5b9ba10639ecece0cb30bd4f Churchyard Gavin J. TRUE 285da50b2e6269d09abfbeb49da9092d CoInvestigator Hanifa Yasmeen TRUE CoInvestigator Fielding Katherine 0000-0002-6524-3754 TRUE CoInvestigator Chihota Violet N. FALSE CoInvestigator Adonis Lungiswa FALSE CoInvestigator Charalambous Salome FALSE CoInvestigator Foster Nicola FALSE CoInvestigator Karstaedt Alan FALSE CoInvestigator McCarthy Kerrigan FALSE CoInvestigator Nicol Mark P. FALSE ProjectManager Ndlovu Nontobeko T. FALSE CoInvestigator Sinanovic Edina FALSE Other Sahid Faieza FALSE CoInvestigator Stevens Wendy FALSE CoInvestigator Vassall Anna TRUE PrincipalInvestigator Churchyard Gavin J. TRUE PrincipalInvestigator Grant Alison D. 0000-0002-2437-5195 TRUE TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom The Aurum Institute, South Africa National Health Laboratory Services, South Africa University of Cape Town, South Africa Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result" EPID ITCR Tuberculosis Diagnostic tests HIV infections South Africa Participant data was collected on the basis that it would be used for ethically-approved HIV and TB related research only. Requesters will be required to provide information on their research and sign a Data Transfer Agreement as a condition of access. The World Health Organization recommends regular tuberculosis screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test. Further evaluation of those who are HIV-positive and Xpert-negative comprises clinical reassessment, chest radiograph (if available), sputum for mycobacterial culture, and treatment with antibiotic if clinically indicated. The aim of our study was to describe the diagnostic yield from an immediate repeat sputum tested with Xpert, compared to sequential further investigation guided by South African recommendations , amongst HIV-positive adults in South Africa being investigated for TB whose initial sputum Xpert result is negative. It was a sub-study of “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR), a prospective cohort study evaluating a risk-based algorithm to prioritise Xpert testing amongst adults attending for routine HIV care in South Africa. This dataset contains data for 227 adults attending for routine HIV care who have an initial negative sputum Xpert result. It includes basic demographics, TB diagnoses, mycobacteriology and chest radiograph results. Data was collected for the purpose of HIV and TB research and can only be reused for related research, in accordance with the participant consent agreement. 2016-08 completed London School of Hygiene & Tropical Medicine 10.17037/DATA.284 Dataset London School of Hygiene & Tropical Medicine, London, United Kingdom The Aurum Institute, South Africa XTBC Interview.FaceToFace SelfAdministeredQuestionnaire.FixedForm.Paper http://purl.org/dc/terms/isPartOf /id/eprint/790 restricted London, United Kingdom Bill and Melinda Gates Foundation Xpert MTB/RIF for people attending HIV care: an interventional cohort study to guide rational implementation (XPHACTOR) Dataset Quantitative A systematic sample of adults attending for HIV care was enrolled to the XPHACTOR study. This substudy was restricted to those at highest risk of tuberculosis (CD4<200 cells/mm3 or unknown) and a negative initial sputum Xpert result. At attendance for the Xpert result, a repeat sputum sample was stored, and further investigations facilitated per national guidelines. Participants were reviewed monthly, with reinvestigation if indicated, for at least three months, when sputum and blood were cultured for mycobacteria, and the stored sputum tested using Xpert. We defined tuberculosis as “confirmed” if Xpert, line probe assay or Mycobacterium tuberculosis culture within six months of enrolment were positive, and “clinical” if tuberculosis treatment was started without microbiological confirmation. OPP1034523 -25.6124 28.47 -26.3482 27.8272 en 2012-09 2014-03 XPHACTOR Clinical Score dataset https://doi.org/10.17037/DATA.204 data The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result https://researchonline.lshtm.ac.uk/id/eprint/4653901 The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result. https://researchonline.lshtm.ac.uk/id/eprint/4666672 Xpert MTB/RIF for people attending HIV care: an interventional cohort study to guide rational implementation (XPHACTOR) Bill and Melinda Gates Foundation OPP1034523 http://dx.doi.org/10.13039/100000865 2016-08