5160 5 archive 3 disk0/00/00/51/60 2026-04-22 10:14:36 2026-04-22 10:14:36 2026-04-22 10:14:36 data_collection show 1 Bousema Teun TRUE 7f95d700c86761c95206dd30215ad788 Drakeley Chris 0000-0003-4863-075X TRUE 3fdd056af9618ed15655a13cb59c4d2e Tiono Alfred TRUE 5bb63b4c3b8b97c4afe89633516372bc London School of Hygiene & Tropical Medicine, London, United Kingdom ITIB Chemoprevention Clinical trials Cluster trials Malaria Medical and health sciences Seasonal Malaria Chemoprevention (SMC) currently targets children below 5 years (< 5 yr). It is unclear what the impact of extending SMC to a wider age range will be. We conducted a cluster-randomized trial in Saponé (Burkina Faso) with three study arms: 1) Programmatic SMC-control arm: SMC in children < 5 years; 2) SMC in children < 5 years, with directly observed treatment (DOTu5); 3) SMC in children < 10 years with DOT (DOTu10). The trial involved 61 (programmatic SMC) and 62 (each DOT arms) clusters of 3 compounds (i.e., 183-186 compounds per arm). The primary endpoint was P. falciparum parasite prevalence at the end of the transmission season; secondary endpoints included clinical malaria incidence, drug plasma levels, and gametocyte prevalence. This trial is complete and is registered with ClinicalTrials.gov, NCT05878366. 2026-03-19 published Dryad Dataset Study authors SelfAdministeredQuestionnaire MeasurementsAndTests none Dataset Quantitative en https://doi.org/10.5061/dryad.9cnp5hr0p dataresource https://researchonline.lshtm.ac.uk/id/eprint/4673785 2026-03-19