This data is from a prospective interventional study (IPSAZ study) conducted in two public-sector antenatal care clinics in Harare, Zimbabwe. Clients attending for ANC were screened in parallel for C. trachomatis, N. gonorrhoeae, T. vaginalis, HBV, HIV, and syphilis, using four different point-of-care tests. This is a cross-sectional dataset, with one row per person, including demographic and clinical data, pregnancy information, and Sexually transmitted infections (STIs) results.