The protocol will result in a validation publication and multiple epidemiology papers (see Explore Further). The validation study was conducted using Clinical Practice Research Datalink (CPRD) Aurum data (September 2023 release) and ICD-10 coded linked Hospital Episode Statistics (HES) data. The epidemiology studies were conducted using CPRD Aurum (March 2023 release) and CPRD GOLD (March 2023) release and and ICD-10 coded linked HES data. Further information is provided in the codelist checklist for each concept.