his dataset supports a realist-informed literature review examining mechanisms that contribute to or reduce vulnerability to cholera outbreaks in Uganda. The data were extracted from documents, including peer-reviewed articles, grey literature, and program evaluations. A six-stage data synthesis approach was used, guided by realist evaluation (Pawson & Tilley, 1997) and resilience frameworks (Blanchet et al., 2017). The dataset includes: 1. An Excel matrix of 31 studies capturing Context–Mechanism–Outcome (CMO) patterns 2. Synthesized CMOC configurations 3. Thematic groupings of resilience and vulnerability mechanisms References and coding for absorptive, adaptive, and transformative capacities.