The African Research on Kidney Disease (ARK) Consortium is a multicenter partnership between Malawi, South Africa, Uganda, and the United Kingdom. The study sites for the ARK Consortium are nested within population cohorts hosted by the Malawi Epidemiology and Intervention Research Unit (MEIRU), the Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) and London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit; and the Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit, South Africa. Our primary objectives were to determine chronic kidney disease (CKD) prevalence (estimated from serum creatinine) and identify associated risk factors.