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    <title>Data supporting &quot;Temporal trends of SARS-CoV-2 exposure in adolescents: a longitudinal pilot study nested in a Uganda birth cohort&quot;</title>
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    <note>Researchers wishing to analyse information on HIV testing and results are advised to complete a request form to contact the MRC/UVRI and LSHTM Uganda Research Unit. Data will be provided on the basis that it is stored securely and not distributed to others.</note>
    <abstract>This dataset comprises individual-level data of a subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort, based in Entebbe municipality, Uganda. Data were drawn from three studies that these participants took part in, where samples were collected: pre-pandemic samples (2014–2016) collected during a blood pressure study; pandemic-era samples collected during the POPVAC C trial (2020–2021) (ISRCTN32849447), which evaluated the impact of BCG revaccination on vaccine responses; and samples from the CoHost study (2021–2022), a 12-month longitudinal follow-up assessing SARS-CoV-2 infection and exposure from participants in the POPVAC B randomised controlled trial. The study aimed to analyse temporal trends in SARS-CoV-2 seropositivity in Ugandan adolescents using pre-pandemic (2014-2016) and pandemic-era samples (2020-2022). We utilised previously stored demographic and clinical data, along with bio-banked samples from these three studies.</abstract>
    <date>2025-05-29</date>
    <date_type>completed</date_type>
    <publisher>London School of Hygiene &amp; Tropical Medicine</publisher>
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    <funders>
      <item>Science for Africa Foundation</item>
      <item>National Institute for Health Research (NIHR)</item>
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      <resourcetype>Quantitative</resourcetype>
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    <collection_method>Previously stored demographic and clinical data, along with bio-banked samples, were used for this study. In the CoHost study, participants were administered a questionnaire capturing demographic information, medical history, SARS-CoV-2 exposure, and recent illness history, recorded using the research electronic data capture (REDCap) application.</collection_method>
    <grant>GCA/SARSCov2-2-20-002</grant>
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        <title>Temporal trends of SARS-CoV-2 exposure in adolescents: a longitudinal pilot study nested in a Uganda birth cohort [version 1; peer review: awaiting peer review]</title>
        <link>https://researchonline.lshtm.ac.uk/id/eprint/4677298</link>
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        <project>CoHost</project>
        <funder_name>Science for Africa Foundation</funder_name>
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