A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis

4647 38 17783 2 97427 document 17783 Protocol_TTE_Benchmarking_trials_in_CF.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document ce7d6bd5b397b5f7ff1a5a5fdbab9550149c3ae36e3899d3d8ad34ed49fb7f88 SHA256 403342 2025-04-08 17:13:57 https://datacompass.lshtm.ac.uk/id/eprint/4647/1/Protocol_TTE_Benchmarking_trials_in_CF.docx 4647 1 1 application/vnd.openxmlformats-officedocument.wordprocessingml.document Text en public cc_by_4

Protocol_TTE_Benchmarking_trials_in_CF.docx

documentation indefinite A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis 17784 1 97445 document 17784 indexcodes.txt text/plain f69d4a4f00601caecba6c4e57b13e92a68ed32caa5fd16b11ba01adfed22acca SHA256 13218 2025-04-08 17:34:08 https://datacompass.lshtm.ac.uk/id/eprint/4647/2/indexcodes.txt 4647 2 2 text/plain en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/17783 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/17783 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/17783 indefinite Generate index codes conversion from Text to indexcodes archive 448 disk0/00/00/46/47 2025-04-08 17:18:49 2025-04-08 17:58:59 2025-04-08 17:18:49 data_collection show Granger Emily 0000-0003-0134-1467 TRUE 50c83f7416c18b390cd8c4f9dab10c9c Allen Lorna FALSE Charman Susan FALSE Clarke Sarah FALSE Davies Gwyneth FALSE Frost Freddy FALSE Plowman Hannah FALSE Tomlinson Laurie A. 0000-0001-8848-9493 TRUE 1bb22d6f4a336a32b420ce3a8d6656bc Keogh Ruth 0000-0001-6504-3253 TRUE 46375742b4476181bf7cb8166ba485bc ProjectLeader Granger Emily 0000-0003-0134-1467 TRUE 50c83f7416c18b390cd8c4f9dab10c9c ProjectLeader Keogh Ruth 0000-0001-6504-3253 TRUE 46375742b4476181bf7cb8166ba485bc London School of Hygiene & Tropical Medicine, London, United Kingdom Cystic Fibrosis Trust UCL Great Ormond Street Institute of Child Health, London, United Kingdom University of Liverpool, Liverpool, United Kingdom A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis EPMS EPNC cystic fibrosis observational study registries target trial emulation This projects aims to: (1) establish best practices for application of target trial emulation methodology using UK CF Registry data to estimate effects of treatments in cystic fibrosis. (2) apply the methods to emulate four existing RCTs that have been conducted assessing the effects of antibiotics. (3) extend Aim 2 to questions that have not yet been studied in RCTs, including to estimate longer-term effects of antibiotics and the effects in CFTR modulator users. 2025-04-08 completed London School of Hygiene & Tropical Medicine 10.17037/PUBS.00004647 Other London School of Hygiene & Tropical Medicine, London, United Kingdom Other 2024-10-01 Granger Emily Emily.Granger@lshtm.ac.uk TRUE 50c83f7416c18b390cd8c4f9dab10c9c public London, United Kingdom National Institute for Health and Care Research Target trial emulation in cystic fibrosis: optimising methods for evaluating antibiotic treatment using registry data Other Research protocol NIHR206915 en Target trial emulation in cystic fibrosis: optimising methods for evaluating antibiotic treatment using registry data National Institute for Health and Care Research NIHR206915 https://doi.org/10.13039/501100000272 National Institute for Health and Care Research NIHR206915 https://doi.org/10.13039/501100000272 2025-04-08