Data for: "Cluster-randomised trial of digital adherence technology interventions to reduce poor end-of-treatment outcomes and recurrence among adults with drug-sensitive tuberculosis in Ethiopia"

4639 44 18032 2 99092 document 18032 ASCENT_EthCRT_data.txt text/plain 4e7092660d6e3fce971b5fafa9d7d5a45680262fb359600b0072caeef645435b SHA256 105 2025-06-19 10:04:39 https://datacompass.lshtm.ac.uk/id/eprint/4639/1/ASCENT_EthCRT_data.txt 4639 1 1 text/plain Dataset en staffonly datasharingagreement

ASCENT_EthCRT_data.txt

data indefinite ASCENT Ethiopia CRT data 18033 1 99095 document 18033 indexcodes.txt text/plain f9ca1d00d2d4dd5b1854e383410f42411fa7d0114ad55123d35dcfc848de2569 SHA256 79 2025-06-19 10:05:59 https://datacompass.lshtm.ac.uk/id/eprint/4639/2/indexcodes.txt 4639 2 2 text/plain other en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/18032 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/18032 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/18032 indefinite Generate index codes conversion from Dataset to indexcodes 18034 2 99099 document 18034 ASCENT_EthCRT_data_codebook.html text/html 39c4929960f3fa04a78b8730d628cd42b08a5b9d0f4f10e509eec378ae06ed29 SHA256 16005 2025-06-19 10:32:44 https://datacompass.lshtm.ac.uk/id/eprint/4639/3/ASCENT_EthCRT_data_codebook.html 4639 3 3 text/html Text en public cc_by_4

ASCENT_EthCRT_data_codebook.html

documentation indefinite Codebook for ASCENT Ethiopia CRT data archive 25 disk0/00/00/46/39 2025-06-23 09:24:29 2025-11-26 10:07:32 2025-06-23 09:24:29 data_collection show Fielding Katherine 0000-0002-6524-3754 TRUE 0aa3885fd6201076535210a253a38f98 Tadesse Amare W. 0000-0002-7805-3191 TRUE fc5237b81dbb2adb668c8e1f1fb2a90e London School of Hygiene & Tropical Medicine, London, United Kingdom KNCV Tuberculosis Plus, Ethiopia KNCV Tuberculosis Plus, The Hague, Netherlands Aurum Institute, Johannesburg, South Africa National Tuberculosis Control Program, Ethiopian Ministry of Health, Addis Ababa, Ethiopia Data for: "Cluster-randomised trial of digital adherence technology interventions to reduce poor end-of-treatment outcomes and recurrence among adults with drug-sensitive tuberculosis in Ethiopia" EPIH tuberculosis treatment Adherence digital health digital adherence technology Data access is embargoed until 1 October 2025. The data are from a pragmatic cluster-randomised trial in Ethiopia. Seventy-eight health facilities (clusters) were randomised to three arms (1:1:1): smart pillbox, medication labels, or standard of care. Adults (≥18 years) with drug-sensitive pulmonary tuberculosis on a fixed-dose combination tuberculosis treatment regimen were enrolled and followed-up for 12 months after treatment initiation. Those in the pillbox arm received a pillbox with customisable audio-visual reminders, while participants in the label arm received their TB medication with a weekly unique code label. Opening the box or texting the code prompted real-time dose logging on the adherence platform, facilitating differentiated response to individual’s adherence by a healthcare worker. The primary outcome comprised death, loss to follow-up, treatment failure, switch to drug-resistant tuberculosis treatment, or recurrence; secondary outcomes included loss to follow-up. Analysis accounted for clustered design with multiple imputation for the primary outcome. The trial is registered with PACTR202008776694999. 2024-06-10 published London School of Hygiene & Tropical Medicine 10.17037/DATA.00004639 Dataset London School of Hygiene & Tropical Medicine, London, United Kingdom XTEG XTBC Interview.FaceToFace Interview.Telephone Observation.Laboratory.Participant Observation.ComputerBased Other 2020-06 2024-01 Tadesse Amare W. Amare.Tadesse@lshtm.ac.uk 0000-0002-7805-3191 TRUE fc5237b81dbb2adb668c8e1f1fb2a90e 18 JC-JCK restricted London, United Kingdom Unitaid Adherence Support Coalition to End TB: evaluation of digital adherence technologies for TB treatment in Ethiopia Dataset Quantitative 2019–33-ASCENT en Cluster-randomized trial of digital adherence technologies and differentiated care to reduce poor end-of-treatment outcomes and recurrence among adults with drug-sensitive pulmonary TB in Ethiopia https://doi.org/10.1101/2024.05.09.24307117 paper Pan African Clinical Trials Registry https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12241 other Equity, cost and disability adjusted life years (DALYs) of tuberculosis treatment supported by digital adherence technologies and differentiated care in Ethiopia: a trial-based distributional cost-effectiveness analysis https://doi.org/10.1101/2024.07.28.24310767 paper Evaluation of implementation and effectiveness of digital adherence technology with differentiated care to support tuberculosis treatment adherence and improve treatment outcomes in Ethiopia: a study protocol for a cluster randomised trial. https://researchonline.lshtm.ac.uk/id/eprint/4663607 Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia https://researchonline.lshtm.ac.uk/id/eprint/4675066/ Adherence Support Coalition to End TB: evaluation of digital adherence technologies for TB treatment in Ethiopia Unitaid 2019–33-ASCENT https://unitaid.org/ Unitaid 2019–33-ASCENT https://unitaid.org/ 2024-06-10