This is a replication dataset for the manuscript titled: "Active vaccine safety surveillance in sub-Saharan Africa: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya." This study conducted in Kilifi county, Kenya involved active safety surveillance of COVID-19 vaccines administered routinely at the participating health facilities. The dataset contains suspected adverse events associated with the COVID-19 vaccines as well as sociodemographic and clinical information of the participants.