Appendix files for "Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa"

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Appendix1-PIS_consent-East_Africa_2.0.pdf

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Appendix2-Monitoring_for_harm.docx

documentation indefinite Appendix 2 - monitoring for harm 17502 2 96249 document 17502 Appendix3-Biological_specimens.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 02ba0928c2614fb4419c92c2b7612f2065c7c8fb674d1bd6a65873c2c871c5c3 SHA256 22788 2025-03-11 10:58:03 https://datacompass.lshtm.ac.uk/id/eprint/4598/3/Appendix3-Biological_specimens.docx 4598 3 3 application/vnd.openxmlformats-officedocument.wordprocessingml.document Text en public cc_public_domain

Appendix3-Biological_specimens.docx

documentation indefinite Appendix 3 - biological specimens 17503 2 96251 document 17503 Appendix4-Spirit_checklist.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 13d7a5a520175b2e651fd7c565308661855ed13a7deff9f6712d5a1e41944db8 SHA256 30842 2025-03-11 10:58:06 https://datacompass.lshtm.ac.uk/id/eprint/4598/4/Appendix4-Spirit_checklist.docx 4598 4 4 application/vnd.openxmlformats-officedocument.wordprocessingml.document Text en public cc_public_domain

Appendix4-Spirit_checklist.docx

documentation indefinite Appendix 4 - Spirit Checklist 17506 1 96274 document 17506 indexcodes.txt text/plain d989b8bc9146c35f0af8220b38e042f45505931f663254c6b87e68dff554aa02 SHA256 7466 2025-03-11 12:08:13 https://datacompass.lshtm.ac.uk/id/eprint/4598/5/indexcodes.txt 4598 5 5 text/plain en public

indexcodes.txt

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indexcodes.txt

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indexcodes.txt

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indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/17503 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/17503 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/17503 indefinite Generate index codes conversion from Text to indexcodes archive 540 disk0/00/00/45/98 2025-03-11 11:00:06 2025-08-28 08:41:26 2025-03-11 11:00:06 data_collection show Hoffman Jeremy 0000-0001-9454-2131 TRUE 19cac4985abfc442e2ba2334bb3b2190 London School of Hygiene & Tropical Medicine, London, United Kingdom Appendix files for "Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa" ITCR Fungal keratitis natamycin This is the first randomised controlled clinical trial comparing natamycin 5% eye drops alone to natamycin 5% and chlorhexidine 0.2% combination eye drops for the treatment of fungal keratitis, an infection to the front of the eye that can lead to blindness if not treated appropriately. This page contains appendix files associated with the trial. 2025-03-06 completed London School of Hygiene & Tropical Medicine 10.17037/DATA.00004598 Other London School of Hygiene & Tropical Medicine, London, United Kingdom XICH Other Hoffman Jeremy Jeremy.Hoffman@lshtm.ac.uk 0000-0001-9454-2131 FALSE 19cac4985abfc442e2ba2334bb3b2190 This is the first randomised controlled clinical trial comparing natamycin 5% eye drops alone to natamycin 5% and chlorhexidine 0.2% combination eye drops for the treatment of fungal keratitis, an infection to the front of the eye that can lead to blindness if not treated appropriately. In this article we describe how we plan to conduct this clinical trial. The primary analysis will be a comparison by arm of best spectacle corrected visual acuity at 3 months, i.e. how well patients can see with glasses if needed at the end of the study period. public London, United Kingdom Wellcome Trust Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa Other SPIRIT Checklist 207472/Z/17/Z Tanzania, Uganda en Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol [version 1; peer review: 2 approved] https://researchonline.lshtm.ac.uk/id/eprint/4677301 Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa Wellcome Trust 207472/Z/17/Z http://dx.doi.org/10.13039/100010269 Wellcome Trust 207472/Z/17/Z http://dx.doi.org/10.13039/100010269 2025-03-06