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      <item>London School of Hygiene &amp; Tropical Medicine, London, United Kingdom</item>
      <item>Biomedical Research &amp; Training Institute, Zimbabwe</item>
      <item>Instituto Nacional de Saúde, Mozambique</item>
      <item>National Institute for Medical Research – Mbeya Medical Research Centre, Tanzania</item>
      <item>LMU Munich, Germany</item>
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    <title>Multimorbidity in tuberculosis-affected households: evaluation of disease clustering and the acceptability and yield of integrated health screening in East and Southern Africa (IMBA Hutano)</title>
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      <item>ITCR</item>
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    <date>2024-07-22</date>
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    <publisher>London School of Hygiene &amp; Tropical Medicine</publisher>
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    <data_type>Project</data_type>
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      <item>London School of Hygiene &amp; Tropical Medicine</item>
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      <item>The Health Research Unit Zimbabwe</item>
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      <date_from>2021-10-04</date_from>
      <date_to>2025-05-04</date_to>
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        <given>Claire</given>
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    <study_abstract>Tuberculosis-affected communities are often highly vulnerable, with social, economic, and biological factors elevating risk of tuberculosis and chronic diseases whilst limiting healthcare access. Tuberculosis, in other words, has syndemic interactions with chronic diseases (such as HIV, undernutrition and diabetes), behaviours (such as smoking and alcohol use) and social factors (such as poverty and crowding). Progress towards TB elimination has been slow, whilst non-communicable diseases (NCDs) have emerged as a major public health threat in Africa. 

This project investigated chronic diseases among TB-affected households and provided evidence on integrated tuberculosis screening and care, in Africa and across high-TB burden settings.   It combined epidemiology with qualitative methods, drawing on data from a tuberculosis household contact cohort study (ERASE-TB) in Mozambique, Tanzania and Zimbabwe, and a nested implementation study in Zimbabwe.

Resources and data relating to the primary analyses of ERASE-TB (evaluation of novel tuberculosis diagnostic tests) are held at LMU Munich (contact: Norbert.Heinrich@med.uni-muenchen.de).</study_abstract>
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        <title>Implications of reference equations for interpretation of spirometry in three African countries: a cross-sectional study</title>
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        <title>Prediction models for Mtb infection among adolescent and adult household contacts in high tuberculosis incidence settings.</title>
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        <title>HIV testing during systematic screening for tuberculosis among household contacts in high-tuberculosis burden settings: a systematic review and meta-analysis.</title>
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        <title>Integrated health checks as a person-centred approach to systematic screening of household tuberculosis contacts: A realist-informed mixed-methods study.</title>
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        <title>HIV, malnutrition, and noncommunicable disease epidemics among tuberculosis-affected households in east and southern Africa: A cross-sectional analysis of the ERASE-TB cohort.</title>
        <link>https://researchonline.lshtm.ac.uk/id/eprint/4679257</link>
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      <item>
        <title>Characterising progression and regression patterns across the spectrum of tuberculosis: a multistate modelling approach.</title>
        <link>https://researchonline.lshtm.ac.uk/id/eprint/4680668</link>
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      <item>
        <title>Principles and priorities for integrated tuberculosis screening and care: A modified Delphi consensus exercise.</title>
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        <funder_name>Wellcome Trust</funder_name>
        <grant>225466/Z/22/Z</grant>
        <funder_id>http://dx.doi.org/10.13039/100010269</funder_id>
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        <funder_name>European and Developing Countries Clinical Trials Partnership</funder_name>
        <grant>RIS2018D-2508</grant>
        <funder_id>http://dx.doi.org/10.13039/501100001713</funder_id>
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        <funder_name>Deutsches Zentrum für Infektionsforschung</funder_name>
        <grant>ttu 02.912_00</grant>
        <funder_id>http://dx.doi.org/10.13039/100009139</funder_id>
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