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documentation indefinite Codebook for laboratory evaluation of PermaNet Dual data tables 17435 1 95761 document 17435 indexcodes.txt text/plain 73c33a5bdaf37c90dd68f0edbe8afaeaa16f2ca365aeca6b9814bc381631b80d SHA256 1899 2025-02-07 10:30:00 https://datacompass.lshtm.ac.uk/id/eprint/4261/8/indexcodes.txt 4261 8 8 text/plain en public

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indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/16309 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/16309 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/16309 indefinite Generate index codes conversion from Text to indexcodes archive 501 disk0/00/00/42/61 2024-07-23 16:28:59 2025-08-05 12:59:03 2024-07-23 16:28:59 data_collection show Syme Thomas 0000-0003-0277-3923 TRUE c932f6a40019f83be9402a8c74fe9b8c N'dombidje Boris FALSE Todjinou Damien FALSE Ariori Victoria FALSE Ngufor Corine 0000-0002-7755-9609 TRUE 8828b96bcc146340af8a65f30d5585b9 PrincipalInvestigator Ngufor Corine 0000-0002-7755-9609 TRUE 8828b96bcc146340af8a65f30d5585b9 CoInvestigator Syme Thomas 0000-0003-0277-3923 TRUE c932f6a40019f83be9402a8c74fe9b8c DataCollector Boris N'dombidje FALSE DataCollector Todjinou Damien FALSE DataCollector Ariori Victoria FALSE London School of Hygiene & Tropical Medicine, London, United Kingdom Centre de Recerche Entomologique de Cotonou PAMVERC Benin ITDC Anopheles gambiae Vector Control Insecticide-treated net Pyrethroid-chlorfenapyr nets have been recommended for malaria control by the World Health Organisation (WHO) after an alpha-cypermethrin-chlorfenapyr net showed improved impact in epidemiological trials. PermaNet® Dual is a new deltamethrin-chlorfenapyr net developed by Vestergaard Sàrl to expand options to control programmes. A series of laboratory studies were performed according to WHO guidelines to assess the regeneration time, efficacy and wash-resistance of PermaNet® Dual. Regeneration time was determined by subjecting net pieces to cone bioassays and tunnel tests before and 0, 1, 2, 3, 5 and 7 days after washing. The wash-resistance of PermaNet® Dual was evaluated compared to WHO-prequalified pyrethroid-only (PermaNet® 2.0) and pyrethroid-chlorfenapyr (Interceptor® G2) nets by testing net pieces washed 0, 1, 3, 5, 10, 15 and 20 times in cone bioassays and tunnel tests. Tests were performed with susceptible and pyrethroid-resistant strains of Anopheles gambiae to assess the pyrethroid and chlorfenapyr components separately. Net pieces were also analysed to determine insecticide content. In regeneration time studies, the biological activity of the deltamethrin and chlorfenapyr components of PermaNet® Dual regenerated within one day after washing and a 1-day washing interval was adopted for wash-resistance studies. PermaNet® Dual induced high mortality (98%) and blood-feeding inhibition (98%) of the susceptible strain after 20 washes fulfilling WHO efficacy criteria in tunnel tests (≥80% mortality, ≥90% blood-feeding inhibition). Similar results were obtained with PermaNet® 2.0 (99% mortality, 99% blood-feeding inhibition) and Interceptor® G2 (99% mortality, 98% blood-feeding inhibition) washed 20 times. In wash-resistance tunnel tests against the pyrethroid-resistant strain, PermaNet® Dual washed 20 times induced high mortality (91%) and blood-feeding inhibition (73%), which was similar to Interceptor® G2 (87% mortality, 79% blood-feeding inhibition) and superior to PermaNet® 2.0 (47% mortality, 68% blood-feeding inhibition). PermaNet® Dual fulfilled WHO efficacy criteria in laboratory bioassays and showed potential to improve control of pyrethroid-resistant malaria vectors. 2024-07-09 completed London School of Hygiene & Tropical Medicine 10.17037/DATA.00004261 Dataset CREC/LSHTM Collaborative Research Programme XMAL Experiment.Laboratory LF-LFZ vector_control NDI public London, United Kingdom UNITAID New nets project Dataset Quantitative A series of laboratory studies were performed according to WHO guidelines to assess the regeneration time, efficacy and wash-resistance of PermaNet® Dual. Regeneration time was determined by subjecting net pieces to cone bioassays and tunnel tests before and 0, 1, 2, 3, 5 and 7 days after washing. The wash-resistance of PermaNet® Dual was evaluated compared to WHO-prequalified pyrethroid-only (PermaNet® 2.0) and pyrethroid-chlorfenapyr (Interceptor® G2) nets by testing net pieces washed 0, 1, 3, 5, 10, 15 and 20 times in cone bioassays and tunnel tests. Tests were performed with susceptible and pyrethroid-resistant strains of Anopheles gambiae to assess the pyrethroid and chlorfenapyr components separately. Net pieces were also analysed to determine insecticide content. en 2020-08-26 2021-03-02 New nets project UNITAID 2024-07-09