Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial"

3758 38 15280 2 84193 document 15280 POPVAC_A_data.txt text/plain 0860292a326e5c290a0ac71e39c98e5521ec3e7b99eb8c760bace6ede22db868 SHA256 56 2024-02-02 14:10:29 https://datacompass.lshtm.ac.uk/id/eprint/3758/1/POPVAC_A_data.txt 3758 1 1 text/plain Dataset en staffonly datasharingagreement

POPVAC_A_data.txt

data indefinite POPVAC A dataset on helminths, trial intervention and vaccines 15281 2 84195 document 15281 POPVAC_A_data_codebook.html text/html e90a2b1198a38244503d687e6c4a574242232f429504286031306ab6dd86be67 SHA256 23893 2024-02-02 14:10:40 https://datacompass.lshtm.ac.uk/id/eprint/3758/2/POPVAC_A_data_codebook.html 3758 2 2 text/html Text en public cc_by_4

POPVAC_A_data_codebook.html

documentation indefinite POPVAC A data dictionary 15282 2 84197 document 15282 3758_UserGuide.html text/html 4d178c9a1d3bbf273bb444795708d75196eb262f202888c33f5d9361024d747e SHA256 8494 2024-02-02 14:10:43 https://datacompass.lshtm.ac.uk/id/eprint/3758/3/3758_UserGuide.html 3758 3 3 text/html Text en public cc_by_4

3758_UserGuide.html

documentation indefinite User guide for POPVAC A dataset 15286 1 84216 document 15286 indexcodes.txt text/plain 0a5ee21fea3a633ceb9516aa4ae82572950599ad9196760dea793e2f6c8136d4 SHA256 38 2024-02-02 14:20:58 https://datacompass.lshtm.ac.uk/id/eprint/3758/4/indexcodes.txt 3758 4 4 text/plain en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/15280 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/15280 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/15280 indefinite Generate index codes conversion from Dataset to indexcodes 17302 1 95628 document 17302 indexcodes.txt text/plain 8426939ecc7c530de507a4afd468e801229c24d49581fefc431def9d008a0ca9 SHA256 2251 2025-02-07 10:26:24 https://datacompass.lshtm.ac.uk/id/eprint/3758/5/indexcodes.txt 3758 5 5 text/plain en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/15281 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/15281 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/15281 indefinite Generate index codes conversion from Text to indexcodes 17303 1 95629 document 17303 indexcodes.txt text/plain 75736fdcfa3b3ac6b713a3ed31dedd2bcc1ef497e6031fa55fc62f97e1f099bf SHA256 1825 2025-02-07 10:26:24 https://datacompass.lshtm.ac.uk/id/eprint/3758/6/indexcodes.txt 3758 6 6 text/plain en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/15282 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/15282 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/15282 indefinite Generate index codes conversion from Text to indexcodes archive 188 disk0/00/00/37/58 2024-02-02 14:12:16 2025-08-21 09:52:18 2024-02-02 14:12:16 data_collection show Nkurunungi Gyaviira 0000-0003-4062-9105 TRUE a48ee0eddf888813b8e342fdb4b32087 Nassuuna Jacent TRUE Natukunda Agnes TRUE e8f9d6363d29c2ef6e98e7ac6b81948a Zirimenya Ludoviko Natukunda TRUE dfdf64063b138a70603f7d21a2b992fb Webb Emily 0000-0002-4019-7456 TRUE 37be87b3e3571ab56ac10ff692e63cd3 Elliott Alison 0000-0003-2818-9549 TRUE d9d54503b6d617709b2d9f1aaf480651 Researcher Zziwa Christopher TRUE d74ece3275c84e8a26cee0c82cb85307 Researcher Ninsiima Caroline TRUE 64ac80426dc5c84f51170f5509ad69d5 Researcher Kabagenyi Joyce TRUE 0a35d2382de7254c46b44fc398efce8b Researcher Kabuubi Prossy TRUE Researcher van Dam Govert FALSE Researcher Corstjens Paul FALSE Researcher Kayiwa John FALSE Researcher Kizza Moses TRUE 9d73359066354253a65e78e64e23b37b Researcher Mutebe Alex TRUE 3c5249e6752e477d11ee8f607daf6d58 Researcher Nakazibwe Esther FALSE Researcher Akello Florence FALSE Researcher Sewankambo Moses TRUE 85cc3eae289493577bd52e12cf81b999 Researcher Kiwanuka Samuel TRUE 9f2aadca65c594f19796342b22c7cfa0 Researcher Cose Stephen 0000-0002-5156-037X TRUE b7986583752c8d421d28d577453066d1 Researcher Wajja Anne 0000-0003-1711-4218 TRUE 3bb439be7ad3f3950fc315c54a7d4859 Researcher Kaleebu Pontiano 0000-0001-9706-2977 TRUE 3dbaaa93a7f1735a81a9e50b796bddcc MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda London School of Hygiene & Tropical Medicine, London, United Kingdom Leiden University Medical Centre, Leiden, Netherlands Data supporting "The effect of intensive praziquantel treatment on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands: results of the POPVAC A randomised, controlled trial" MRCUVRI Schistosoma mansoni Praziquantel Vaccine response Children Randomised controlled trial To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed. This dataset comprises individual-level data from participants in the POPVAC A randomised controlled trial. POPVAC A was an open-label randomised controlled trial of intensive versus standard intervention against Schistosoma mansoni among schoolchildren (9-17 years) in Koome islands, Uganda (ISRCTN60517191). The aim of the trial was to comprehensively address the hypothesis that Schistosoma mansoni infection causes suppression of responses to unrelated vaccines and that this effect can be reversed by intensive treatment with praziquantel. The trial population was selected to comprise children at intense risk of exposure to Schistosoma mansoni infection in a “hot-spot”, island setting in Lake Victoria, Uganda. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of intensive treatment of Schistosoma mansoni on immune response to vaccines with different characteristics. 2024-01-29 completed London School of Hygiene & Tropical Medicine 10.17037/DATA.00003758 Dataset MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda SelfAdministeredQuestionnaire Observation.Laboratory 176 MH HG-Vaccines SQL RK-DR restricted London, United Kingdom Medical Research Council Medical Research Council POPVAC POPVAC Dataset Quantitative MR/R02118X/1 en 2019-07 2020-10 ISRCTN Registry https://doi.org/10.1186/ISRCTN60517191 other POPVAC B RCT data https://doi.org/10.17037/DATA.00003759 data POPVAC C RCT data https://doi.org/10.17037/DATA.00003760 data POPVAC settings data https://doi.org/10.17037/DATA.00003761 data The effect of intensive praziquantel administration on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands (POPVAC A): an open-label, randomised controlled trial. https://researchonline.lshtm.ac.uk/id/eprint/4674108 POPVAC Medical Research Council MR/R02118X/1 http://dx.doi.org/10.13039/501100000265 POPVAC Medical Research Council MC_PC_21034 http://dx.doi.org/10.13039/501100000265 2024-01-29