The study used a mixed-methods approach based upon an online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK’s mass COVID-19 vaccination programme (December 2020). Key outputs include: a tabular dataset containing survey responses, a data dictionary that explains survey data variables, an R scripts that enable reproduction of analyses (Analysis_Script.R),  and an ancillary R script providing patched functions for parallel imputation, (parlmice_commands.R).