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SMC_Safety_Monitoring_Report.pdf

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SMC_DrugResistance_Baseline_Report.pdf

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SMC_DrugResistance_Survey_Report.pdf

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http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/11800 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/11800 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/11800 indefinite Generate index codes conversion from Text to indexcodes archive 64 disk0/00/00/21/36 2021-09-10 10:13:40 2025-11-14 14:27:12 2021-09-10 10:13:40 data_collection show Milligan Paul 0000-0003-3430-3395 TRUE f89e771702e1b23788797da3139d98d0 London School of Hygiene & Tropical Medicine, London, United Kingdom Malaria Consortium Catholic Relief Services, United States Medicines for Malaria Venture, Geneva, Switzerland Speak Up Africa Management Sciences for Health EPID Seasonal Malaria Chemoprevention Sahel ACCESS-SMC This collection contains data collected as part of the SMC coverage surveys, case control studies, malaria incidence at health facilities, and molecular markers of resistance, as well as the accompanying protocols, reports, and tools produced by the Access-SMC study. Please consult the file listing for further information. Data held for preservation only. Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in the Sahel (ACCESS-SMC) project sought to remove barriers to the scale-up of SMC in seven countries in 2015 and 2016. We evaluated the project, including coverage, effectiveness of the intervention, safety, feasibility, drug resistance, and cost-effectiveness. For this observational study, we collected data on the delivery, effectiveness, safety, influence on drug resistance, costs of delivery, impact on malaria incidence and mortality, and cost-effectiveness of SMC, during its administration for 4 months each year (2015 and 2016) to children younger than 5 years, in Burkina Faso, Chad, The Gambia, Guinea, Mali, Republic of the Niger, and Nigeria. SMC was administered monthly by community health workers who visited door-to-door. Drug administration was monitored via tally sheets and via household cluster-sample coverage surveys. Pharmacovigilance was based on targeted spontaneous reporting and monitoring systems were strengthened. Molecular markers of resistance to sulfadoxine–pyrimethamine and amodiaquine in the general population before and 2 years after SMC introduction was assessed from community surveys. Effectiveness of monthly SMC treatments was measured in case-control studies that compared receipt of SMC between patients with confirmed malaria and neighbourhood-matched community controls eligible to receive SMC. Impact on incidence and mortality was assessed from confirmed outpatient cases, hospital admissions, and deaths associated with malaria, as reported in national health management information systems in Burkina Faso and The Gambia, and from data from selected outpatient facilities (all countries). Provider costs of SMC were estimated from financial costs, costs of health-care staff time, and volunteer opportunity costs, and cost-effectiveness ratios were calculated as the total cost of SMC in each country divided by the predicted number of cases averted. This collection contains data collected as part of the SMC coverage surveys, case control studies, malaria incidence at health facilities, and molecular markers of resistance, as well as the accompanying protocols, reports, and tools produced by the Access-SMC study. Please consult the file listing for further information. 2021-03-25 completed London School of Hygiene & Tropical Medicine 10.17037/DATA.00002136 Dataset London School of Hygiene & Tropical Medicine, London, United Kingdom XMAL SelfAdministeredQuestionnaire 146 1414 1416 1418 149 LF-LFZ SP-SPE-DC UXC-UXU restricted London, United Kingdom UNITAID ACCESS-SMC Dataset Quantitative Coverage surveys: household survey questionnaires Case control studies: questionnaires Molecular marker surveys: survey questionnaires and lab data Impact: health facility data on confirmed malaria cases from clinic registers en fr 2014-01-01 2021-05-31 https://doi.org/10.1371/journal.pmed.1003727 paper https://researchonline.lshtm.ac.uk/id/eprint/4658592 https://researchonline.lshtm.ac.uk/id/eprint/4659399 ACCESS-SMC UNITAID https://unitaid.org/#en 2021-03-25