1824 26 8822 2 41676 document 8822 HIV_virological_failure_and_resistance_data.txt text/plain d031357aebeb868c99f9711d37c37150d8540a39bc282fb7b083dcc898c43435 SHA256 53 2020-08-10 09:06:30 https://datacompass.lshtm.ac.uk/id/eprint/1824/1/HIV_virological_failure_and_resistance_data.txt 1824 1 1 text/plain Dataset en staffonly datasharingagreement

HIV_virological_failure_and_resistance_data.txt

data 10 HIV virological failure and drug resistance dataset 8823 1 41688 document 8823 indexcodes.txt text/plain c76257582dbabf7a8c058de3f1ec335957418fe2808c9f7ae823a26c2bfd7583 SHA256 40 2020-08-10 09:26:39 https://datacompass.lshtm.ac.uk/id/eprint/1824/2/indexcodes.txt 1824 2 2 text/plain en staffonly

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/8822 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/8822 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/8822 indefinite Generate index codes conversion from Dataset to indexcodes archive 153 disk0/00/00/18/24 2020-08-10 09:18:23 2025-12-11 09:14:27 2020-08-10 09:18:23 data_collection show Gupta-Wright Ankur TRUE e25b14bcc34beb6e1b7be97df8c0afdf ProjectLeader Gupta-Wright Ankur TRUE London School of Hygiene & Tropical Medicine, London, United Kingdom ITCR HIV Virological failure Drug resistance Human Immunodeficiency Virus Dataset in preparation. Please contact data creator directly. This dataset contains information collected as part of a cohort study to investigate ART failure, drug resistance, and early mortality among patients with HIV admitted to hospital in Malawi. The observational cohort study was nested within the rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalised patients in Africa (STAMP) trial, which recruited unselected (i.e. irrespective of clinical presentation), adult (aged ≥18 years) patients with HIV-1 at admission to medical wards. Patients were included in our observational cohort study if they were enrolled at the Malawi site (Zomba Central Hospital) and were taking ART for at least 6 months at admission. Patients who met inclusion criteria had frozen plasma samples tested for HIV-1 viral load. Those with HIV-1 RNA of at least 1000 copies per mL had drug resistance testing by ultra-deep sequencing, with drug resistance defined as intermediate or high-level resistance using the Stanford HIVDR program. Mortality risk was calculated 56 days from enrolment. Patients were censored at death, at 56 days, or at last contact if lost to follow-up. The modelling strategy addressed the causal association between HIV multidrug resistance and mortality, excluding factors on the causal pathway (most notably, CD4 cell count, clinical signs of advanced HIV, and poor functional and nutritional status). 2020-08-06 published London School of Hygiene & Tropical Medicine 10.17037/DATA.00001824 Dataset London School of Hygiene & Tropical Medicine, London, United Kingdom XTBC MeasurementsAndTests.Physical 173 KM EK-EO K RK-DR SY-SYQZ restricted London, United Kingdom Department for International Development, UK Government Medical Research Council National Institute for Health Research (NIHR) Wellcome Trust STAMP trial STAMP trial STAMP trial STAMP trial Dataset Quantitative MR/M007375/1 -15.243 35.4813 -15.4655 35.1867 en 2015-10-26 2017-09-19 https://doi.org/10.1016/S2352-3018(20)30172-7 paper https://researchonline.lshtm.ac.uk/id/eprint/4659499 STAMP trial Department for International Development, UK Government MR/M007375/1 http://dx.doi.org/10.13039/501100002992 STAMP trial Medical Research Council MR/M007375/1 http://dx.doi.org/10.13039/501100000265 STAMP trial National Institute for Health Research (NIHR) MR/M007375/1 http://dx.doi.org/10.13039/501100000272 STAMP trial Wellcome Trust MR/M007375/1 http://dx.doi.org/10.13039/100010269 Joint Global Health Trials Scheme MR/M007375/1 2020-08-06