166 40 1332 5 4956 document 1332 Data_Tables.zip application/x-zip 00791a8e5b2b59760e68dd5239b6d591bed9b32bbb5e4a01cdfc2ffa6d1665f1 SHA256 2857 2016-02-16 17:14:43 https://datacompass.lshtm.ac.uk/id/eprint/166/1/Data_Tables.zip 166 1 1 application/x-zip Dataset en public cc_by

Data_Tables.zip

data indefinite Table 1-3 contained within publication archive 3 disk0/00/00/01/66 2016-02-16 14:42:17 2025-05-30 08:32:32 2016-02-16 14:42:17 data_collection show Lazzarino Antonio TRUE b94a5e7207f6c09c55af5e7edbcf8129 Hamer Mark FALSE Gaze David FALSE Collinson Paul FALSE Steptoe Andrew FALSE CoInvestigator Marmot Michael FALSE DataCollector Chida Yoichi FALSE DataCollector Endrighi Romano FALSE DataCollector Murray Bev FALSE DataCollector O'Donnell Katie FALSE DataCollector Urbanova Livia FALSE DataCollector Walker Cecily FALSE University College London, London, United Kingdom St. George's Healthcare NHS Trust, London, United Kingdom EPPH Atherosclerotic plaque Computed tomography Myocardial infarction Psychological stress Troponin T Open access publication funded by the British Heart Foundation The objective of this study was to examine the association between cortisol response to mental stress and high-sensitivity cardiac troponin T (hs-cTnT) in healthy older individuals without history of cardiovascular disease (CVD). Mental stress is a recognized risk factor for CVD, although the mechanisms remain unclear. Cortisol, a key stress hormone, is associated with coronary atherosclerosis and may accentuate structural and functional cardiac disease. This cross-sectional study involved 508 disease-free men and women aged 53 to 76 years drawn from the Whitehall II epidemiological cohort. We evaluated salivary cortisol response to standardized mental stress tests (exposure) and hs-cTnT plasma concentration using a high-sensitivity assay (outcome). We measured coronary calcification using electron-beam dual-source computed tomography and Agatston scores. After adjustment for demographic and clinical variables associated with CVD as well as for inflammatory factors, we found a robust association between cortisol response and detectable hs-cTnT (odds ratio [OR]: 3.98; 95% confidence interval [CI]: 1.60 to 9.92; p = 0.003). The association remained when we restricted the analysis to participants without coronary calcification (n = 222; OR: 4.77; 95% CI: 1.22 to 18.72; p = 0.025) or when we further adjusted for coronary calcification in participants with positive Agatston scores (n = 286; OR: 7.39; 95% CI: 2.22 to 26.24; p = 0.001). We found that heightened cortisol response to mental stress was associated with detectable plasma levels of cTnT using high-sensitivity assays in healthy participants, independently of coronary atherosclerosis. Further research is needed to understand the role of psychosocial stress in the pathophysiology of cardiac cell damage. 2013-06-27 published Journal of the American College of Cardiology Dataset Study consortium Observation.Laboratory public 62 18 British Heart Foundation Dataset Quantitative en https://doi.org/10.1016/j.jacc.2013.05.070 dataresource http://researchonline.lshtm.ac.uk/id/eprint/2529421 British Heart Foundation http://dx.doi.org/10.13039/501100000274 British Heart Foundation 2013-06-27