102 21 1385 2 5112 document 1385 data1_EvolApplic.txt text/plain 565d59f035a02c9da5028716f5b9717fe1064fd527ba7c73964148c06a93e499 SHA256 25116 2016-02-18 10:51:29 https://datacompass.lshtm.ac.uk/id/eprint/102/1/data1_EvolApplic.txt 102 1 1 text/plain Dataset en public cc_by

data1_EvolApplic.txt

data indefinite Experiment 1: the effect of Vavraia on juvenile survival and adult longevity. Text file with column headers, column separated by commas 1386 2 5114 document 1386 data2_EvolApplic.txt text/plain fa549512951169943e1d898e1a43fa8a8a7654bed0695d8caeefa87935ba55e6 SHA256 2457 2016-02-18 10:51:31 https://datacompass.lshtm.ac.uk/id/eprint/102/2/data2_EvolApplic.txt 102 2 2 text/plain Dataset en public cc_by

data2_EvolApplic.txt

data indefinite Experiment 2: effect of Vavraia on age-specific fecundity. Text file with column headers; columns separated by commas 1387 1 5119 document 1387 indexcodes.txt text/plain 2dd354b9f40e8d81f7607dc6f59c346f24f67fd0b67bcb2db32b7764a6f51d4e SHA256 1600 2016-02-18 11:01:31 https://datacompass.lshtm.ac.uk/id/eprint/102/3/indexcodes.txt 102 3 3 text/plain other en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/1385 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/1385 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/1385 indefinite Generate index codes conversion from Dataset to indexcodes 1388 1 5120 document 1388 indexcodes.txt text/plain fa2281d716bdd5c03ed7a258f1a4f98c5dd13b9e09f64604603340297e6f6af8 SHA256 86 2016-02-18 11:01:31 https://datacompass.lshtm.ac.uk/id/eprint/102/4/indexcodes.txt 102 4 4 text/plain other en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://datacompass.lshtm.ac.uk/id/document/1386 http://eprints.org/relation/isVolatileVersionOf https://datacompass.lshtm.ac.uk/id/document/1386 http://eprints.org/relation/isIndexCodesVersionOf https://datacompass.lshtm.ac.uk/id/document/1386 indefinite Generate index codes conversion from Dataset to indexcodes archive 3 disk0/00/00/01/02 2015-11-05 14:51:57 2025-06-17 10:16:04 2015-11-05 14:51:57 data_collection show Lorenz Lena TRUE 373ad053c9c7ace7bb357b2521f406ab Koella Jacob C FALSE London School of Hygiene & Tropical Medicine, London, United Kingdom Imperial College London, London, United Kingdom ITDC Anopheles gambiae Vavraia culicis Microsporidian parasites are being considered as alternatives to conventional insecticides for malaria control. They should reduce malaria transmission by shortening the lifespan of female mosquitoes and thus killing them before they transmit malaria. As the parasite replicates throughout the mosquito’s life, it should have little detrimental effects on young mosquitoes, thus putting less selection pressure on the hosts to evolve resistance. Here we examined these expectations for the microsporidian Vavraia culicis on Anopheles gambiae Giles sensu stricto mosquitoes under varying environmental conditions. Infection by the microsporidian delayed pupation by 10%, decreased fecundity by 23% and reduced adult lifespan by 27%, with higher infectious doses causing greater effects. The decrease of the lifespan was mostly due to an increase of the mortality rate with age. Similarly, the parasite’s effect on mosquito fecundity increased with the mosquitoes’ age. Neither infection nor food availability affected juvenile survival. Thus, as V. culicis reduced the longevity of A. gambiae (s.s.), yet affected mortality and fecundity of the young mosquitoes only slightly, the microsporidian is a promising alternative to insecticides for effective malaria control that will impose little evolutionary pressure for resistance. 2011-06-13 published Dryad digital repository Dataset London School of Hygiene & Tropical Medicine, London, United Kingdom Imperial College London, London, United Kingdom Experiment public Natural Environment Research Council Dataset Quantitative NE/F011288/1 en https://doi.org/10.5061/dryad.2s231 dataresource http://researchonline.lshtm.ac.uk/id/eprint/39516 Natural Environment Research Council NE/F011288/1 http://dx.doi.org/10.13039/501100000270 NE/F011288/1 2011-06-13