10.17037/DATA.00005362
Data collected as part of a cross-sectional interferon-gamma release assay (IGRA) survey of healthy children, aged 1 to 4 years living in 33 high-burden neighbourhoods in Blantyre, Malawi. Participants were recruited through a combination of a novel convenience sampling approach in health facilities and random household sampling guided by satellite imagery. They were subsequently tested for Mycobacterium tuberculosis (Mtb) immunoreactivity using QFT-Plus IGRA.
The files provided include a cleaned dataset covering participants with a QFT-Plus result, an R Markdown script written to perform the analyses, and accompanying data documentation. These were used to generate the analyses outlined in "Heterogeneity in Mycobacterium tuberculosis immunoreactivity in young children in Blantyre, Malawi: a community-based survey".
This dataset contains 26 variables, outlined below.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| age | Age at study enrolment (Rounded to 0.5 years) | Numeric | ||
| sex | Participant sex | String | ||
| Female | Female | |||
| Male | Male | |||
| cluster | Study cluster ID | String | ||
| qftp | IGRA result | String | ||
| Negative | Negative | |||
| Positive | Positive | |||
| rec_location | Location of participant recruitment | String | ||
| Clinic | Clinic | |||
| Community | Community | |||
| hivstatus_binary | HIV status | String | ||
| HIV Negative or Unknown | HIV Negative or Unknown | |||
| HIV Positive | HIV Positive | |||
| hiv_exp_bin | HIV exposure status | String | ||
| HIV exposed (maternal HIV) | hiv_exp | |||
| HIV unexposed | hiv_unexp | |||
| Not applicable | NA | |||
| currentcough_ind | Current cough | String | ||
| No | No | |||
| Yes | Yes | |||
| any_tbsx | Any current TB symptoms | String | ||
| No | No | |||
| Yes | Yes | |||
| bcg_ind | Previous BCG vaccination | String | ||
| No | No | |||
| Yes | Yes | |||
| tbrx_cat | Previous TB treatment | String | ||
| No | No | |||
| Yes | Yes | |||
| genhealth_cat | Caregiver-reported general health | String | ||
| Poor | Poor | |||
| Fair | Fair | |||
| Good | Good | |||
| Excellent | Excellent | |||
| muacz_2 | Nutritional status based on MUAC-Z score | String | ||
| MUACZ below -2SD | MUACZ below -2 | |||
| MUACZ normal | MUACZ normal | |||
| church_weekly | Frequency of church attendance | String | ||
| Less than weekly | Less than weekly | |||
| Weekly | Weekly | |||
| hosp_amt_yn | Hospital admission in lifetime | String | ||
| No | No | |||
| Yes | Yes | |||
| locschool_ind | Current school attendance | String | ||
| No | No | |||
| Yes | Yes | |||
| travel_yn | Ever travelled outside Blantyre | String | ||
| No | No | |||
| Yes | Yes | |||
| clinic_catchment | Nearest of 3 clinics | String | ||
| Clinic A | A | |||
| Clinic B | B | |||
| Clinic C | C | |||
| hh_members_n | Number of household members | Open ended | Numeric | |
| crowding | Household members per room (household crowding) | Open ended | Numeric | |
| means_score_tertile | Household socioeconomic status based on means score | Numeric | ||
| Poorest tertile | 1 | |||
| Middle tertile | 2 | |||
| Richest tertile | 3 | |||
| poorest_third | Household socioeconomic status based on means score (Dichotomised variable) | String | ||
| Poorest | Poorest | |||
| Not poorest | Not_poorest | |||
| educ_3 | Educational level of household head | String | ||
| Primary or below | Primary or below | |||
| Some secondary education | Some secondary education | |||
| Completed secondary or above | Completed secondary or above | |||
| educ_bin | Educational level of household head (Dichotomised variable) | String | ||
| Primary | Primary | |||
| Secondary | Secondary | |||
| distance_to_clinic | Distance from household to clinic (Rounded to 0.5 kilometres) | Open ended | Numeric | |
| tb_hhc_lifetime | History of TB household contact | String | ||
| No | No | |||
| Yes | Yes |