10.17037/DATA.00005144
This dataset comprises individual-level data from 699 participants in the POPVAC A and POPVAC C randomised controlled trials. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting). POPVAC C was undertaken in Entebbe municipality among participants of the Entebbe Mother and Baby Study (EMaBS) cohort. Variables include data on socio-demographic characteristics, S. mansoni infection, and oral typhoid vaccine-specific plasma and copro-antibody responses.
The Uganda Coproantibodies dataset contains 28 variables outlined below.
| Variable Name | Variable Label | Answer Label | Variable Type |
| id | Participant ID | Open ended | String |
| setting | Study setting | String | |
| Urban | |||
| Rural | |||
| trialarm | Standard or Intensive anthelminthic treatment arm (rural setting); BCG or no BCG revaccination arm (urban setting) | String | |
| Intensive-rural | |||
| Standard-rural | |||
| BCG arm-urban | |||
| no BCG arm-urban | |||
| age | Participant age in years | 9 through 17 | Numeric |
| sex | Participant sex | String | |
| Female | |||
| Male | |||
| ty1d1_w4 | Oral typhoid (Ty21a) vaccine dose 1 administration at the week 4 timepoint | String | |
| No | |||
| Yes | |||
| ty1d2_w4 | Oral typhoid (Ty21a) vaccine dose 2 administration at the week 4 timepoint | String | |
| No | |||
| Yes | |||
| ty1d3_w4 | Oral typhoid (Ty21a) vaccine dose 3 administration at the week 4 timepoint | String | |
| No | |||
| Yes | |||
| doses | Number of Ty21a doses administered | 1 to 3 | Numeric |
| caa_screening_caa | CAA concentration at screening timepoint, pg/ml | 0 through 404684.3 | Numeric |
| result_screening_caa | S. mansoni infection status, based on CAA concentration at screening timepoint (cutoff 30 pg/ml) | String | |
| Negative | |||
| Positive | |||
| smres_screen | S. mansoni infection status, PCR, screening timepoint | String | |
| Negative | |||
| Positive | |||
| smct_screen | Ct value for S. mansoni DNA in stool, screening timepoint | 18.3314 through 39.768; NA= >40 ct value / undetectable DNA | String |
| sm_screening_caa_pcr | S. mansoni infection status, based on CAA concentration (cutoff 30 pg/ml) or PCR, at screening timepoint | String | |
| Negative | |||
| Positive | |||
| typhi_igg_wk0 | S. typhi O:LPS-specific plasma IgG (EU/ml), Week 0 | 5.76 through 4589.44 | Numeric |
| typhi_igg_wk8 | S. typhi O:LPS-specific plasma IgG (EU/ml), Week 8 | 8.32 through 6631.68 | Numeric |
| typhi_plasma_iga_wk0 | S. typhi O:LPS-specific plasma IgA (EU/ml), Week 0 | 0 through 13439.68 | Numeric |
| typhi_plasma_iga_wk8 | S. typhi O:LPS-specific plasma IgA (EU/ml), Week 8 | 0 through 13439.68 | Numeric |
| typhi_copro_iga_baseline | S. typhi O:LPS-specific copro-IgA (ng/ml), screening timepoint | 0 through 623.047 | Numeric |
| typhi_copro_iga_week8 | S. typhi O:LPS-specific copro-IgA (ng/ml), Week 8 | 0 through 623.047 | Numeric |
| total_copro_iga_screening | total copro-IgA (ng/ml), screening timepoint | 0 through 239.137 | Numeric |
| total_copro_iga_week8 | total copro-IgA (ng/ml), Week 8 | 0 through 267.165 | Numeric |
| typhi_copro_igg_screening | S. typhi O:LPS-specific copro-IgG (ng/ml), screening timepoint | 0 through 38.87 | Numeric |
| typhi_copro_igg_week8 | S. typhi O:LPS-specific copro-IgG (ng/ml), Week 8 | 0 through 231.613 | Numeric |