10.17037/DATA.204
The World Health Organization (WHO) recommendation for regular tuberculosis (TB) screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test has major resource implications. The aim of our study was to develop a score, comprising elements readily available in primary care, to predict probability of TB in adults attending for routine HIV care screened for TB and found WHO tool positive.
We used data collected for “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR), a prospective cohort study evaluating a risk-based algorithm to prioritise Xpert MTB/RIF testing amongst adults attending for routine HIV care in South Africa, to develop and validate our clinical score.
This dataset contains data for 1,048 HIV-positive adults attending for routine HIV care and reporting ≥1 symptom on the WHO screening tool. The dataset is split 50:50 to derive, and internally validate the prediction model. It includes basic demographics, TB diagnoses, and candidate predictors considered for the score. Data was collected for the purpose of HIV and TB research and can only be reused for related research, in accordance with the participant consent agreement.
| Variable name | Variable description | Answer code | Answer label | Variable type |
| idnum | Participant study ID | Numeric | ||
| group | Prediction or validation dataset | Numeric | ||
| 1 | Prediction | |||
| 2 | Validation | |||
| TB | TB diagnosed over 6 months of follow up | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| CaseDef | TB case definition | Numeric | ||
| 0 | Not TB | |||
| 1 | Confirmed TB | |||
| 2 | Clinical TB | |||
| ptypcat | Participant category | Numeric | ||
| 0 | On ART | |||
| 1 | Pre-ART | |||
| artnew | ART status | Numeric | ||
| 0 | on ART for ≥3 months | |||
| 1 | pre-ART or on ART <3 months | |||
| age | Age (years) | Numeric | ||
| sex | Sex | Numeric | ||
| 1 | Male | |||
| 2 | Female | |||
| smokcat | Smoking status | Numeric | ||
| 0 | Never smoked | |||
| 1 | Current or ex-smoker | |||
| alcohol | Alcohol status | Numeric | ||
| 1 | Alcohol in last 1 year | |||
| 2 | No alcohol in last 1 year | |||
| prevtb | Previous TB treatment | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| inhgp | Ever had isoniazid preventive therapy | Numeric | ||
| 0 | No or don’t know | |||
| 1 | Yes | |||
| ctxgp | Ever had cotrimoxazole preventive therapy | Numeric | ||
| 0 | No or don’t know | |||
| 1 | Yes | |||
| bmi | Body mass index (kg/m2) | Numeric | ||
| cd4 | CD4 (cells/mm3) | Numeric | ||
| coua | Cough reported | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| feva | Fever reported | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| nsa | Night sweats reported | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| uwla | Unintentional weight loss reported | Numeric | ||
| 0 | No | |||
| 1 | Yes | |||
| whonumber | Total number of WHO tool symptoms reported | Numeric | ||
| numsympt | Number of WHO tool symptoms categorised | Numeric | ||
| 0 | 1 symptom | |||
| 1 | ≥2 symptoms | |||
| symptom1wk | Duration WHO tool-positive categorised | Numeric | ||
| 0 | <7 days | |||
| 1 | ≥7 days |