Search strategy D for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic D was simply defined as: Falciparum malaria AND (treatment failure OR drug resistance) AND non-endemic countries AND (randomised controlled trials OR observational studies OR case-series) Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 January 17 Date searched: 2025-01-20 Searched by: JF Number of hits: 721 EndNote import number: 2 Number of results after deduplication: 555 1 exp Plasmodium falciparum/ or exp malaria falciparum/ or exp cerebral malaria/ 62308 2 (falciparum or (severe adj2 malaria*)).ti,ab. 55493 3 1 or 2 [falciparum] 71065 4 treatment failure/ or "lack of drug effect"/ or recurrent disease/ or exp reinfection/ or relapse/ or recrudescence/ 643640 5 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 3404819 6 exp drug resistance/ or antimalarial drug resistance/ 422936 7 resist*.ti,ab. 1793466 8 or/4-7 [treatment failure or resistance] 5194027 9 travel/ or travel related disease/ or emporiatrics/ 72535 10 exp military personnel/ or military deployment/ or military service/ or military medicine/ 73485 11 clergy/ 7132 12 exp migrant/ or undocumented immigrant/ 57525 13 (non-endemic or "not endemic").ti,ab,kf. 6985 14 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab,kf. 369453 15 Albania/ or Albania.ti,ab,kf. 2874 16 Algeria/ or Algeria.ti,ab,kf. 8921 17 Andorra/ or Andorra.ti,ab,kf. 153 18 "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab,kf. 378 19 Argentina/ or Argentina.ti,ab,kf. 38080 20 Armenia/ or Armenia.ti,ab,kf. 3329 21 exp "Australia and New Zealand"/ or Australia.ti,ab,kf. 334245 22 Austria/ or Austria.ti,ab,kf. 37884 23 exp Azerbaijan/ or Azerbaijan.ti,ab,kf. 3527 24 Bahamas/ or Bahamas.ti,ab,kf. 1292 25 Bahrain/ or Bahrain.ti,ab,kf. 2761 26 Barbados/ or Barbados.ti,ab,kf. 1607 27 Belarus/ or Belarus.ti,ab,kf. 4251 28 exp Belgium/ or Belgium.ti,ab,kf. 43833 29 Belize/ or Belize.ti,ab,kf. 1361 30 exp "Bosnia and Herzegovina"/ or (Bosnia or Herzegovina).ti,ab,kf. 4864 31 Brunei Darussalam/ or Brunei.ti,ab,kf. 1011 32 Bulgaria/ or Bulgaria.ti,ab,kf. 14310 33 exp Canada/ or Canada.ti,ab,kf. 281992 34 Chile/ or Chile.ti,ab,kf. 30049 35 exp China/ or China.ti,ab,kf. 505314 36 Croatia/ or Croatia.ti,ab,kf. 16217 37 Cuba/ or Cuba.ti,ab,kf. 10449 38 Cyprus/ or Cyprus.ti,ab,kf. 4566 39 Czech Republic/ or (Czech Republic or Czechia).ti,ab,kf. 23135 40 exp Denmark/ or Denmark.ti,ab,kf. 78773 41 Dominica/ or Dominica.ti,ab,kf. 750 42 Egypt/ or Egypt.ti,ab,kf. 37300 43 El Salvador/ or El Salvador.ti,ab,kf. 3291 44 Estonia/ or Estonia.ti,ab,kf. 6305 45 Fiji/ or Fiji.ti,ab,kf. 4223 46 exp Finland/ or Finland.ti,ab,kf. 57275 47 exp France/ or France.ti,ab,kf. 202165 48 Gambia/ or Gambia.ti,ab,kf. 4412 49 exp "Georgia (Republic)"/ or Georgia.ti,ab,kf. 16460 50 exp Germany/ or Germany.ti,ab,kf. 296346 51 Greece/ or Greece.ti,ab,kf. 41966 52 Grenada/ or Grenada.ti,ab,kf. 586 53 Guyana/ or Guyana.ti,ab,kf. 2060 54 Hungary/ or Hungary.ti,ab,kf. 34227 55 Iceland/ or Iceland.ti,ab,kf. 9711 56 exp Iraq/ or Iraq.ti,ab,kf. 20314 57 Ireland/ or (Ireland or Eire).ti,ab,kf. 190635 58 Israel/ or Israel.ti,ab,kf. 52895 59 exp Italy/ or Italy.ti,ab,kf. 190592 60 Jamaica/ or Jamaica.ti,ab,kf. 6259 61 Japan/ or Japan.ti,ab,kf. 338370 62 Jordan/ or Jordan.ti,ab,kf. 14549 63 Kazakhstan/ or Kazakhstan.ti,ab,kf. 7134 64 Kiribati/ or Kiribati.ti,ab,kf. 333 65 Kuwait/ or Kuwait.ti,ab,kf. 7972 66 Kyrgyzstan/ or Kyrgyzstan.ti,ab,kf. 2552 67 Latvia/ or Latvia.ti,ab,kf. 4064 68 Lebanon/ or Lebanon.ti,ab,kf. 10567 69 Lesotho/ or Lesotho.ti,ab,kf. 1435 70 Libyan Arab Jamahiriya/ or Libya.ti,ab,kf. 2790 71 Liechtenstein/ or Liechtenstein.ti,ab,kf. 573 72 Lithuania/ or Lithuania.ti,ab,kf. 6999 73 Luxembourg/ or Luxembourg.ti,ab,kf. 2644 74 Maldives/ or Maldives.ti,ab,kf. 801 75 Malta/ or Malta.ti,ab,kf. 3489 76 marshall islands/ or Marshall Islands.ti,ab,kf. 487 77 Mauritius/ or Mauritius.ti,ab,kf. 1704 78 exp "Federated States of Micronesia"/ or Micronesia.ti,ab,kf. 1519 79 Moldova/ or Moldova.ti,ab,kf. 1936 80 Monaco/ or Monaco.ti,ab,kf. 1963 81 Mongolia/ or Mongolia.ti,ab,kf. 8557 82 "Montenegro (republic)"/ 1040 83 "Montenegro (republic)"/ or Montenegro.ti,ab,kf. 1860 84 Morocco/ or Morocco.ti,ab,kf. 14183 85 nauru/ or Nauru.ti,ab,kf. 236 86 Netherlands/ or (Netherlands or Holland).ti,ab,kf. 131094 87 New Zealand.ti,ab,kf. 88643 88 "Republic of North Macedonia"/ or North Macedonia.ti,ab,kf. 1620 89 exp Norway/ or Norway.ti,ab,kf. 72305 90 Oman/ or Oman.ti,ab,kf. 5808 91 Palau/ or Palau.ti,ab,kf. 630 92 Palestine/ or Palestine.ti,ab,kf. 3811 93 Paraguay/ or Paraguay.ti,ab,kf. 3169 94 Poland/ or Poland.ti,ab,kf. 78701 95 exp Portugal/ or Portugal.ti,ab,kf. 33934 96 Qatar/ or Qatar.ti,ab,kf. 6428 97 Romania/ or Romania.ti,ab,kf. 21540 98 exp Russian Federation/ or Russia.ti,ab,kf. 86447 99 "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab,kf. 272 100 Saint Lucia/ or Saint Lucia.ti,ab,kf. 212 101 "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab,kf. 448 102 exp samoan islands/ or Samoa.ti,ab,kf. 1698 103 San Marino/ or San Marino.ti,ab,kf. 218 104 exp Serbia/ or Serbia.ti,ab,kf. 11082 105 Seychelles/ or Seychelles.ti,ab,kf. 1089 106 Singapore/ or Singapore.ti,ab,kf. 39545 107 Slovakia/ or Slovakia.ti,ab,kf. 9482 108 Slovenia/ or Slovenia.ti,ab,kf. 8882 109 exp Spain/ or Spain.ti,ab,kf. 151037 110 Sri Lanka/ or Sri Lanka.ti,ab,kf. 14684 111 Sweden/ or Sweden.ti,ab,kf. 123180 112 Switzerland/ or Switzerland.ti,ab,kf. 82001 113 Syrian Arab Republic/ or Syria.ti,ab,kf. 5486 114 Tajikistan/ or Tajikistan.ti,ab,kf. 1565 115 Tonga/ or Tonga.ti,ab,kf. 767 116 "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab,kf. 4129 117 Tunisia/ or Tunisia.ti,ab,kf. 16738 118 "Turkey (republic)"/ or (Turkey or Turkiye).ti,ab,kf. 87188 119 Turkmenistan/ or Turkmenistan.ti,ab,kf. 950 120 Tuvalu/ or Tuvalu.ti,ab,kf. 125 121 exp Ukraine/ or Ukraine.ti,ab,kf. 24156 122 exp United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab,kf. 13755 123 exp United Kingdom/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab,kf. 771576 124 exp United States/ or (United States or America or USA).ti,ab,kf. 2039043 125 Uruguay/ or Uruguay.ti,ab,kf. 6024 126 exp Uzbekistan/ or Uzbekistan.ti,ab,kf. 3802 127 or/9-126 [non-endemic countries] 6345847 128 exp clinical trial/ 1989210 129 clinical study/ or exp case control study/ or intervention study/ or exp longitudinal study/ or major clinical study/ or prospective study/ or retrospective study/ 7119956 130 exp controlled study/ or cohort analysis/ or observational study/ or cross-sectional study/ or case study/ 12234747 131 case-control.tw. 220862 132 (cohort adj (study or studies)).tw. 540844 133 cohort analy$.tw. 22698 134 (follow up adj (study or studies)).tw. 83438 135 (observational adj (study or studies)).tw. 294912 136 longitudinal.tw. 496679 137 retrospective.tw. 1426013 138 cross-sectional.tw. 777086 139 case-series.tw. 164757 140 randomized.ab. 974249 141 placebo.ab. 379766 142 randomly.ab. 597671 143 trial.ti. 454154 144 or/128-143 16577744 145 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/ 1273881 146 animal experiment/ not (human experiment/ or human/) 2684313 147 145 or 146 2763523 148 144 not 147 [study types] 14737645 149 3 and 8 and 127 and 148 1282 150 limit 149 to yr="2010 -Current" 726 151 remove duplicates from 150 721 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 03 Date searched: 2025-01-20 Searched by: JF Number of hits: 154 EndNote import number: 3 Number of results after deduplication: 42 1 plasmodium falciparum/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ 50070 2 falciparum.ti,ab. 47053 3 (severe adj2 malaria*).ti,ab. 4484 4 or/1-3 [falciparum] 53280 5 treatment failure/ or reinfection/ or relapse/ 48344 6 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 260137 7 exp drug resistance/ 164594 8 resist*.ti,ab. 383785 9 or/5-8 [treatment failure or resistance] 620093 10 travel/ or international travel/ 7612 11 travel associated diseases/ 756 12 travel medicine/ 2505 13 exp tourism/ 8827 14 exp military personnel/ 13977 15 military medicine/ 487 16 migrants/ or visitors/ 7131 17 immigrants/ or immigration/ 10852 18 refugees/ 6067 19 imported infections/ 9715 20 (non-endemic or "not endemic").ti,ab. 4619 21 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab. 112157 22 Albania/ or Albania.ti,ab. 1656 23 Algeria/ or Algeria.ti,ab. 7226 24 Andorra/ or Andorra.ti,ab. 55 25 exp "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab. 254 26 Argentina/ or Argentina.ti,ab. 18221 27 Armenia/ or Armenia.ti,ab. 1225 28 exp Australia/ or Australia.ti,ab. 80484 29 Austria/ or Austria.ti,ab. 11182 30 Azerbaijan/ or Azerbaijan.ti,ab. 2138 31 Bahamas/ or Bahamas.ti,ab. 355 32 Bahrain/ or Bahrain.ti,ab. 1069 33 Barbados/ or Barbados.ti,ab. 784 34 Belarus/ or Belarus.ti,ab. 1443 35 Belgium/ or Belgium.ti,ab. 14289 36 Belize/ or Belize.ti,ab. 766 37 bosnia-hercegovina/ or (Bosnia or Herzegovina).ti,ab. 2442 38 brunei darussalam/ or Brunei.ti,ab. 432 39 Bulgaria/ or Bulgaria.ti,ab. 7345 40 exp Canada/ or Canada.ti,ab. 67632 41 Chile/ or Chile.ti,ab. 11623 42 exp China/ or China.ti,ab. 303085 43 Croatia/ or Croatia.ti,ab. 6912 44 Cuba/ or Cuba.ti,ab. 6741 45 Cyprus/ or Cyprus.ti,ab. 2114 46 Czech Republic/ or (Czech Republic or Czechia).ti,ab. 8175 47 exp Denmark/ or Denmark.ti,ab. 23629 48 Dominica/ or Dominica.ti,ab. 437 49 exp Egypt/ or Egypt.ti,ab. 26325 50 El Salvador/ or El Salvador.ti,ab. 1814 51 Estonia/ or Estonia.ti,ab. 2520 52 Fiji/ or Fiji.ti,ab. 1722 53 exp Finland/ or Finland.ti,ab. 18813 54 exp France/ or France.ti,ab. 63120 55 Gambia/ or Gambia.ti,ab. 3984 56 "republic of georgia"/ or Georgia.ti,ab. 6731 57 exp Germany/ or Germany.ti,ab. 66491 58 exp Greece/ or Greece.ti,ab. 16468 59 Grenada/ or Grenada.ti,ab. 410 60 Guyana/ or Guyana.ti,ab. 1531 61 Hungary/ or Hungary.ti,ab. 9392 62 Iceland/ or Iceland.ti,ab. 2601 63 Iraq/ or Iraq.ti,ab. 9174 64 irish republic/ or (Ireland or Eire).ti,ab. 11507 65 Israel/ or Israel.ti,ab. 15445 66 exp Italy/ or Italy.ti,ab. 73617 67 Jamaica/ or Jamaica.ti,ab. 3424 68 exp Japan/ or Japan.ti,ab. 77976 69 Jordan/ or Jordan.ti,ab. 5855 70 Kazakhstan/ or Kazakhstan.ti,ab. 4384 71 Kiribati/ or Kiribati.ti,ab. 283 72 Kuwait/ or Kuwait.ti,ab. 2863 73 Kyrgyzstan/ or Kyrgyzstan.ti,ab. 1042 74 Latvia/ or Latvia.ti,ab. 2123 75 Lebanon/ or Lebanon.ti,ab. 4346 76 Lesotho/ or Lesotho.ti,ab. 1055 77 Libya/ or Libya.ti,ab. 1920 78 Liechtenstein/ or Liechtenstein.ti,ab. 124 79 Lithuania/ or Lithuania.ti,ab. 3104 80 Luxembourg/ or Luxembourg.ti,ab. 900 81 Maldives/ or Maldives.ti,ab. 428 82 Malta/ or Malta.ti,ab. 1745 83 marshall islands/ or Marshall Islands.ti,ab. 250 84 exp Mauritius/ or Mauritius.ti,ab. 1301 85 "federated states of micronesia"/ or micronesia.ti,ab. 487 86 Moldova/ or Moldova.ti,ab. 1071 87 Monaco/ or Monaco.ti,ab. 111 88 Mongolia/ or Mongolia.ti,ab. 3523 89 Montenegro/ or Montenegro.ti,ab. 1059 90 Morocco/ or Morocco.ti,ab. 10032 91 Nauru/ or Nauru.ti,ab. 185 92 Netherlands/ or (Netherlands or Holland).ti,ab. 38628 93 exp New Zealand/ or New Zealand.ti,ab. 23716 94 "republic of north macedonia"/ or North Macedonia.ti,ab. 1772 95 exp Norway/ or Norway.ti,ab. 18106 96 Oman/ or Oman.ti,ab. 2313 97 Palau/ or Palau.ti,ab. 235 98 exp Palestine/ or Palestine.ti,ab. 2995 99 Paraguay/ or Paraguay.ti,ab. 1997 100 Poland/ or Poland.ti,ab. 30920 101 exp Portugal/ or Portugal.ti,ab. 12236 102 Qatar/ or Qatar.ti,ab. 1711 103 Romania/ or Romania.ti,ab. 12718 104 exp Russia/ or Russia.ti,ab. 24301 105 exp "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab. 235 106 Saint Lucia/ or Saint Lucia.ti,ab. 474 107 exp "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab. 267 108 Samoa/ or American Samoa/ or Samoa.ti,ab. 1149 109 San Marino/ or San Marino.ti,ab. 77 110 exp Serbia/ or Serbia.ti,ab. 6085 111 exp Seychelles/ or Seychelles.ti,ab. 567 112 Singapore/ or Singapore.ti,ab. 9230 113 Slovakia/ or Slovakia.ti,ab. 5013 114 Slovenia/ or Slovenia.ti,ab. 4970 115 exp Spain/ or Spain.ti,ab. 58825 116 Sri Lanka/ or Sri Lanka.ti,ab. 9599 117 Sweden/ or Sweden.ti,ab. 32965 118 Switzerland/ or Switzerland.ti,ab. 19285 119 Syria/ or Syria.ti,ab. 2642 120 Tajikistan/ or Tajikistan.ti,ab. 1028 121 Tonga/ or Tonga.ti,ab. 472 122 exp "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab. 2786 123 Tunisia/ or Tunisia.ti,ab. 8839 124 Turkey/ or (Turkey or Turkiye).ti,ab. 55883 125 Turkmenistan/ or Turkmenistan.ti,ab. 782 126 Tuvalu/ or Tuvalu.ti,ab. 152 127 Ukraine/ or Ukraine.ti,ab. 5807 128 exp United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab. 4202 129 exp UK/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab. 138103 130 exp USA/ or (United States or America or USA).ti,ab. 471950 131 Uruguay/ or Uruguay.ti,ab. 3724 132 Uzbekistan/ or Uzbekistan.ti,ab. 2317 133 or/10-132 [non-endemic countries] 1841210 134 exp clinical trials/ 101322 135 case-control studies/ 38239 136 cohort studies/ 100515 137 case-control.tw. 74464 138 (cohort adj (study or studies)).tw. 114791 139 cohort analy$.tw. 3263 140 (follow up adj (study or studies)).tw. 10346 141 observational studies/ 15059 142 (observational adj (study or studies)).tw. 43796 143 longitudinal studies/ 17328 144 longitudinal.tw. 66482 145 retrospective studies/ 45637 146 retrospective.tw. 124205 147 cross-sectional studies/ 43604 148 cross-sectional.tw. 212333 149 case-series.tw. 10144 150 randomized.ab. 114108 151 placebo.ab. 48827 152 randomly.ab. 125408 153 trial.ti. 52108 154 or/134-153 804732 155 exp animals/ not (man/ or human.sh.) 1088122 156 154 not 155 751738 157 4 and 9 and 133 and 156 320 158 limit 157 to yr="2010 -Current" 154 159 remove duplicates from 158 154 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to January 17, 2025 Date searched: 2025-01-20 Searched by: JF Number of hits: 214 EndNote import number: 1 Number of results after deduplication: 211 1 Plasmodium falciparum/ or exp Malaria, Falciparum/ or malaria, cerebral/ 43484 2 falciparum.ti,ab. 43190 3 (severe adj2 malaria*).ti,ab. 5008 4 or/1-3 [falciparum] 54424 5 treatment failure/ or recurrence/ or reinfection/ 241368 6 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 2229777 7 exp Drug Resistance/ 394145 8 resist*.ti,ab. 1396973 9 or/5-8 [treatment failure or resistance] 3636078 10 exp Travel/ or Travel Medicine/ 32928 11 Holidays/ 3359 12 Military Personnel/ or Military Medicine/ or Military Deployment/ 68271 13 exp "Emigrants and Immigrants"/ or Missionaries/ 17312 14 "Transients and Migrants"/ 15269 15 Communicable Diseases, Imported/ 606 16 (non-endemic or "not endemic").ti,ab,kf. 5326 17 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab,kf. 296002 18 Albania/ or Albania.ti,ab,kf. 1775 19 Algeria/ or Algeria.ti,ab,kf. 5757 20 Andorra/ or Andorra.ti,ab,kf. 106 21 "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab,kf. 332 22 Argentina/ or Argentina.ti,ab,kf. 28437 23 Armenia/ or Armenia.ti,ab,kf. 2438 24 exp Australia/ or Australia.ti,ab,kf. 231074 25 Austria/ or Austria.ti,ab,kf. 30862 26 Azerbaijan/ or Azerbaijan.ti,ab,kf. 2484 27 Bahamas/ or Bahamas.ti,ab,kf. 1048 28 Bahrain/ or Bahrain.ti,ab,kf. 1688 29 Barbados/ or Barbados.ti,ab,kf. 1275 30 "Republic of Belarus"/ or Belarus.ti,ab,kf. 3035 31 Belgium/ or Belgium.ti,ab,kf. 33066 32 Belize/ or Belize.ti,ab,kf. 1191 33 "Bosnia and Herzegovina"/ or (Bosnia or Herzegovina).ti,ab,kf. 3801 34 Brunei/ or Brunei.ti,ab,kf. 739 35 Bulgaria/ or Bulgaria.ti,ab,kf. 9349 36 exp Canada/ or Canada.ti,ab,kf. 241594 37 Chile/ or Chile.ti,ab,kf. 25244 38 exp China/ or China.ti,ab,kf. 470891 39 Croatia/ or Croatia.ti,ab,kf. 11311 40 Cuba/ or Cuba.ti,ab,kf. 7738 41 Cyprus/ or Cyprus.ti,ab,kf. 3240 42 Czech Republic/ or (Czech Republic or Czechia).ti,ab,kf. 14539 43 exp Denmark/ or Denmark.ti,ab,kf. 75482 44 Dominica/ or Dominica.ti,ab,kf. 644 45 Egypt/ or Egypt.ti,ab,kf. 28785 46 El Salvador/ or El Salvador.ti,ab,kf. 1846 47 Estonia/ or Estonia.ti,ab,kf. 4475 48 Fiji/ or Fiji.ti,ab,kf. 2878 49 Finland/ or Finland.ti,ab,kf. 52812 50 exp France/ or France.ti,ab,kf. 153776 51 Gambia/ or Gambia.ti,ab,kf. 3903 52 "Georgia (Republic)"/ or Georgia.ti,ab,kf. 13869 53 exp Germany/ or Germany.ti,ab,kf. 198316 54 Greece/ or Greece.ti,ab,kf. 29686 55 Grenada/ or Grenada.ti,ab,kf. 442 56 Guyana/ or Guyana.ti,ab,kf. 1567 57 Hungary/ or Hungary.ti,ab,kf. 25790 58 Iceland/ or Iceland.ti,ab,kf. 8054 59 Iraq/ or Iraq.ti,ab,kf. 12073 60 Ireland/ or (Ireland or Eire).ti,ab,kf. 38345 61 Israel/ or Israel.ti,ab,kf. 46347 62 exp Italy/ or Italy.ti,ab,kf. 159091 63 Jamaica/ or Jamaica.ti,ab,kf. 5193 64 exp Japan/ or Japan.ti,ab,kf. 244225 65 Jordan/ or Jordan.ti,ab,kf. 11244 66 Kazakhstan/ or Kazakhstan.ti,ab,kf. 5281 67 Kiribati.ti,ab,kf. 282 68 Kuwait/ or Kuwait.ti,ab,kf. 5621 69 Kyrgyzstan/ or Kyrgyzstan.ti,ab,kf. 1998 70 Latvia/ or Latvia.ti,ab,kf. 2667 71 Lebanon/ or Lebanon.ti,ab,kf. 8777 72 Lesotho/ or Lesotho.ti,ab,kf. 1160 73 Libya/ or Libya.ti,ab,kf. 2147 74 Liechtenstein/ or Liechtenstein.ti,ab,kf. 448 75 Lithuania/ or Lithuania.ti,ab,kf. 5340 76 Luxembourg/ or Luxembourg.ti,ab,kf. 1720 77 Maldives/ or Maldives.ti,ab,kf. 587 78 Malta/ or Malta.ti,ab,kf. 2052 79 Marshall Islands.ti,ab,kf. 375 80 Mauritius/ or Mauritius.ti,ab,kf. 1383 81 exp Micronesia/ or Micronesia.ti,ab,kf. 2722 82 Moldova/ or Moldova.ti,ab,kf. 1252 83 Monaco/ or Monaco.ti,ab,kf. 619 84 Mongolia/ or Mongolia.ti,ab,kf. 7202 85 Montenegro/ or Montenegro.ti,ab,kf. 1189 86 Morocco/ or Morocco.ti,ab,kf. 11054 87 Nauru.ti,ab,kf. 176 88 Netherlands/ or (Netherlands or Holland).ti,ab,kf. 107008 89 New Zealand/ or New Zealand.ti,ab,kf. 86876 90 "Republic of North Macedonia"/ or North Macedonia.ti,ab,kf. 890 91 exp Norway/ or Norway.ti,ab,kf. 64663 92 Oman/ or Oman.ti,ab,kf. 4918 93 Palau/ or Palau.ti,ab,kf. 556 94 Palestine.ti,ab,kf. 2573 95 Paraguay/ or Paraguay.ti,ab,kf. 2290 96 Poland/ or Poland.ti,ab,kf. 68028 97 Portugal/ or Portugal.ti,ab,kf. 25496 98 Qatar/ or Qatar.ti,ab,kf. 4226 99 Romania/ or Romania.ti,ab,kf. 16288 100 exp Russia/ or Russia.ti,ab,kf. 68581 101 "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab,kf. 241 102 Saint Lucia/ or Saint Lucia.ti,ab,kf. 151 103 "Saint Vincent and the Grenadines"/ 59 104 "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab,kf. 312 105 exp Samoa/ or Samoa.ti,ab,kf. 1440 106 San Marino/ or San Marino.ti,ab,kf. 150 107 Serbia/ or Serbia.ti,ab,kf. 7463 108 Seychelles/ or Seychelles.ti,ab,kf. 1002 109 Singapore/ or Singapore.ti,ab,kf. 25671 110 Slovakia/ or Slovakia.ti,ab,kf. 6184 111 Slovenia/ or Slovenia.ti,ab,kf. 5992 112 Spain/ or Spain.ti,ab,kf. 126093 113 Sri Lanka/ or Sri Lanka.ti,ab,kf. 11378 114 Sweden/ or Sweden.ti,ab,kf. 110503 115 Switzerland/ or Switzerland.ti,ab,kf. 57877 116 Syria/ or Syria.ti,ab,kf. 4863 117 Tajikistan/ or Tajikistan.ti,ab,kf. 1325 118 Tonga/ or Tonga.ti,ab,kf. 683 119 "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab,kf. 3293 120 Tunisia/ or Tunisia.ti,ab,kf. 12918 121 Turkey/ or (Turkey or Turkiye).ti,ab,kf. 69809 122 Turkmenistan/ or Turkmenistan.ti,ab,kf. 912 123 Tuvalu.ti,ab,kf. 96 124 Ukraine/ or Ukraine.ti,ab,kf. 21166 125 United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab,kf. 9648 126 exp United Kingdom/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab,kf. 562478 127 exp United States/ or (United States or America or USA).ti,ab,kf. 1863163 128 Uruguay/ or Uruguay.ti,ab,kf. 4328 129 Uzbekistan/ or Uzbekistan.ti,ab,kf. 2695 130 or/10-129 [ALL NON-ENDEMIC MALARIA COUNTRIES] 5281993 131 exp clinical trial/ or observational study/ 1177630 132 epidemiologic studies/ or exp case-control studies/ or exp cohort studies/ or cross-sectional studies/ 3381572 133 case-control.tw. 168440 134 (cohort adj (study or studies)).tw. 380235 135 cohort analy$.tw. 14196 136 (follow up adj (study or studies)).tw. 59609 137 (observational adj (study or studies)).tw. 192602 138 longitudinal.tw. 364751 139 retrospective.tw. 869136 140 cross-sectional.tw. 603908 141 case-series.tw. 117589 142 (adaptive clinical trial or clinical study or clinical trial or clinical trial phase i or clinical trial phase ii or clinical trial phase iii or clinical trial phase iv or comparative study or controlled clinical trial or multicenter study or observational study or pragmatic clinical trial or randomized controlled trial).pt. 3064667 143 randomized.ab. 676453 144 placebo.ab. 255354 145 clinical trials as topic.sh. 204187 146 randomly.ab. 451101 147 trial.ti. 327094 148 or/131-147 7069450 149 exp animals/ not humans.sh. 5297693 150 148 not 149 6462863 151 4 and 9 and 130 and 150 521 152 limit 151 to yr="2010 -Current" 214 153 remove duplicates from 152 214 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-01-18 Date searched: 2025-01-20 Searched by: JF Number of hits: 124 EndNote import number: 4 Number of results after deduplication: 8 1: TI=("falciparum" or ("severe" near/2 malaria*)) or AB=("falciparum" or ("severe" near/2 malaria*)) Results: 45923 2: TI=(fail* or recurr* or reinfect* or relaps* or recrudesc* or resist*) or AB=(fail* or recurr* or reinfect* or relaps* or recrudesc* or resist*) Results: 5377750 3: TI=("non-endemic" or "not endemic") or AB=("non-endemic" or "not endemic") Results: 5313 4: TI=(travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or (("army" or "navy" or "armed forces" or "air force") near/1 "personnel") or expat* or missionar* or migrant$ or immigrant$ or emigrant$ or refugee* or "asylum" or (import* near/2 (infect* or diseas*)) or (visit* near/2 (friend* or "family" or "families" or relativ* or relation*)) or "vfr") or AB=(travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or (("army" or "navy" or "armed forces" or "air force") near/1 "personnel") or expat* or missionar* or migrant$ or immigrant$ or emigrant$ or refugee* or "asylum" or (import* near/2 (infect* or diseas*)) or (visit* near/2 (friend* or "family" or "families" or relativ* or relation*)) or "vfr") Results: 887049 5: TI=("Albania" or "Algeria" or "Andorra" or "Antigua" or "Barbuda" or "Argentina" or "Armenia" or "Australia" or "Austria" or "Azerbaijan" or "Bahamas" or "Bahrain" or "Barbados" or "Belarus" or "Belgium" or "Belize" or "Bosnia" or "Herzegovina" or "Brunei" or "Bulgaria" or "Canada" or "Chile" or "China" or "Croatia" or "Cuba" or "Cyprus" or "Czech Republic" or "Czechia" or "Denmark" or "Dominica" or "Egypt" or "El Salvador" or "Estonia" or "Fiji" or "Finland" or "France" or "Gambia" or "Georgia" or "Germany" or "Greece" or "Grenada" or "Guyana" or "Hungary" or "Iceland" or "Iraq" or "Ireland" or "Eire" or "Israel" or "Italy" or "Jamaica" or "Japan" or "Jordan" or "Kazakhstan" or "Kiribati" or "Kuwait" or "Kyrgyzstan" or "Latvia" or "Lebanon" or "Lesotho" or "Libya" or "Liechtenstein" or "Lithuania" or "Luxembourg" or "Maldives" or "Malta" or "Marshall Islands" or "Mauritius" or "Micronesia" or "Moldova" or "Monaco" or "Mongolia" or "Montenegro" or "Morocco" or "Nauru" or "Netherlands" or "Holland" or "New Zealand" or "North Macedonia" or "Norway" or "Oman" or "Palau" or "Palestine" or "Paraguay" or "Poland" or "Portugal" or "Qatar" or "Romania" or "Russia" or "Saint Kitts" or "Nevis" or "Saint Lucia" or "Saint Vincent" or "Grenadines" or "Samoa" or "San Marino" or "Serbia" or "Seychelles" or "Singapore" or "Slovakia" or "Slovenia" or "Spain" or "Sri Lanka" or "Sweden" or "Switzerland" or "Syria" or "Tajikistan" or "Tonga" or "Trinidad" or "Tobago" or "Tunisia" or "Turkey" or "Turkiye" or "Turkmenistan" or "Tuvalu" or "Ukraine" or "United Arab Emirates" or "UAE" or "United Kingdom" or "Britain" or "UK" or "GBR" or "England" or "Scotland" or "Wales" or "United States" or "America" or "USA" or "Uruguay" or "Uzbekistan") Results: 2892278 6: AB=("Albania" or "Algeria" or "Andorra" or "Antigua" or "Barbuda" or "Argentina" or "Armenia" or "Australia" or "Austria" or "Azerbaijan" or "Bahamas" or "Bahrain" or "Barbados" or "Belarus" or "Belgium" or "Belize" or "Bosnia" or "Herzegovina" or "Brunei" or "Bulgaria" or "Canada" or "Chile" or "China" or "Croatia" or "Cuba" or "Cyprus" or "Czech Republic" or "Czechia" or "Denmark" or "Dominica" or "Egypt" or "El Salvador" or "Estonia" or "Fiji" or "Finland" or "France" or "Gambia" or "Georgia" or "Germany" or "Greece" or "Grenada" or "Guyana" or "Hungary" or "Iceland" or "Iraq" or "Ireland" or "Eire" or "Israel" or "Italy" or "Jamaica" or "Japan" or "Jordan" or "Kazakhstan" or "Kiribati" or "Kuwait" or "Kyrgyzstan" or "Latvia" or "Lebanon" or "Lesotho" or "Libya" or "Liechtenstein" or "Lithuania" or "Luxembourg" or "Maldives" or "Malta" or "Marshall Islands" or "Mauritius" or "Micronesia" or "Moldova" or "Monaco" or "Mongolia" or "Montenegro" or "Morocco" or "Nauru" or "Netherlands" or "Holland" or "New Zealand" or "North Macedonia" or "Norway" or "Oman" or "Palau" or "Palestine" or "Paraguay" or "Poland" or "Portugal" or "Qatar" or "Romania" or "Russia" or "Saint Kitts" or "Nevis" or "Saint Lucia" or "Saint Vincent" or "Grenadines" or "Samoa" or "San Marino" or "Serbia" or "Seychelles" or "Singapore" or "Slovakia" or "Slovenia" or "Spain" or "Sri Lanka" or "Sweden" or "Switzerland" or "Syria" or "Tajikistan" or "Tonga" or "Trinidad" or "Tobago" or "Tunisia" or "Turkey" or "Turkiye" or "Turkmenistan" or "Tuvalu" or "Ukraine" or "United Arab Emirates" or "UAE" or "United Kingdom" or "Britain" or "UK" or "GBR" or "England" or "Scotland" or "Wales" or "United States" or "America" or "USA" or "Uruguay" or "Uzbekistan") Results: 4758276 7: #3 OR #4 OR #5 OR #6 Results: 6953540 8: TS=("case-control" or ("cohort" near/1 ("study" or "studies")) or "cohort analy*" or ("follow up" near/1 ("study" or "studies")) or ("observational" near/1 ("study" or "studies")) or "longitudinal" or "retrospective" or "cross-sectional" or "case-series") or AB=("randomized" or "placebo" or "randomly") or TI=("trial") Results: 4151672 9: TI=("rat" or "rats" or "mouse" or "mice" or "swine" or "porcine" or "murine" or "sheep" or "lambs" or "pigs" or "piglets" or "rabbit" or "rabbits" or "cat" or "cats" or "dog" or "dogs" or "cattle" or "bovine" or "monkey" or "monkeys" or "trout" or marmoset*) NOT TS=("man" or "human") Results: 2529961 10: #8 not #9 Results: 4047382 11: #10 AND #7 AND #2 AND #1 Results: 197 12: #11 Timespan: 2010-01-01 to 2025-12-31 Results: 124