Search strategy methods for: "UK malaria treatment guidelines" Methodology A series of 12 topics for inclusion in the project were developed by the project team. Draft searches on each of these topics were compiled in the Ovid Medline ALL database by an experienced information professional. The search strategies included strings of terms, synonyms and subject headings to reflect the following concepts: Topic A. Malaria [all species] AND (anti-malaria drugs OR treatment failure) AND randomised controlled trials Topic B. Falciparum malaria AND (anti-malaria drugs OR outpatients) AND non-endemic countries AND (randomised controlled trials OR observational studies OR case-series) Topic C. Falciparum malaria AND (bacteraemia or sepsis) AND non-endemic countries AND case series Topic D. Falciparum malaria AND (treatment failure OR drug resistance) AND non-endemic countries AND (randomised controlled trials OR observational studies OR case-series) Topic E. (Falciparum malaria OR artesunate) AND haemolysis AND non-endemic countries AND (observational studies OR case-series) Topic F. Malaria [all species] AND (newborns OR infants OR mothers OR pregnancy) AND non-endemic countries NOT case reports Topic G. (Congenital Malaria OR (malaria [all species] AND (pregnancy OR newborns OR infants OR breastfeeding))) AND diagnostic tests AND (sensitivity or specificity) Topic H. Malaria [all species] AND pregnancy AND treatment failure AND (randomised controlled trials or observational studies) Topic I. [search not required] Topic J. Congenital malaria AND prevalence Topic K. Malaria [all species] AND (pregnancy OR placental malaria) AND anti-malaria drugs Topic L. Severe falciparum malaria AND (intravenous quinine OR intravenous artesunate) NOT case reports Topic M. Malaria [all species] AND blood film AND (sensitivity or specificity) AND non-endemic countries The non-endemic countries search string was compiled by removing countries on the list of WHO malaria-endemic countries from a list of countries of the world and combining this with synonyms for returning travellers, migrants or military personnel used in a previous review.(1) Topics limited to non-endemic countries were limited to publication year 2010 to current. Worldwide searches were limited to publication year 2021 to current as this was when the latest WHO worldwide guidelines were produced. Results were limited to human-only studies. No other limits were applied. The search strategies were refined with the project team until the retrieved results reflected the scope of each topic. Once agreed, the draft search was adapted for each database to incorporate database-specific syntax and controlled vocabularies. The results from each topic search were uploaded to separate EndNote libraries. Duplicates were removed from within each topic search using the method described on the LSHTM LAORS blog.(2) Sources The following four databases were searched for each topic. Exact dates are included with each topic search strategy. Supplier Database name Ovid Embase Classic+Embase Ovid Global Health Ovid Medline ALL Clarivate Analytics Web of Science Core Collection. This consists of the following databases, searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Search strategies Search strategies for each topic listed above are published in separate files associated with this one. These include date of database update, date the search was run, number of results, results remaining after duplicates removed and the number of the database in the duplication order. References 1. Thakker C, Warrell C, Barrett J, et al. UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants. J Infect. 2025;90(2):106328. doi: 10.1016/j.jinf.2024.106328. 2. Falconer J. Removing duplicates from an EndNote library. Library & Archives Service Blog: London School of Hygiene & Tropical Medicine. 2018. [online blog] http://blogs.lshtm.ac.uk/library/2018/12/07/removing-duplicates-from-an-endnote-library/.