Search strategy K for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic K was simply defined as: Malaria [all species] AND (pregnancy OR placental malaria) AND anti-malaria drugs Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 March 12 Date searched: 2025-03-13 Searched by: JF Number of hits: 245 EndNote import number: 2 Number of results after deduplication: 159 1 malaria/ or exp cerebral malaria/ or exp malaria falciparum/ or plasmodium knowlesi malaria/ or plasmodium malariae infection/ or plasmodium ovale malaria/ or plasmodium vivax malaria/ 124210 2 plasmodium/ or exp plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 70648 3 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 149157 4 or/1-3 176774 5 parasitic pregnancy complication/ or expectant mother/ or exp pregnancy/ or pregnant woman/ or exp infectious pregnancy complication/ or pregnancy complication/ or maternal infection/ or puerperal infection/ 1084682 6 (pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 1038562 7 exp placenta/ 106655 8 fetus blood/ 9481 9 umbilical cord blood/ 42529 10 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 232743 11 exp mother to child transmission/ or vertical transmission/ 21610 12 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 19788 13 or/5-12 1553542 14 4 and 13 10647 15 placenta malaria/ 729 16 or/14-15 10698 17 antimalarial agent/ 31702 18 artemisinin derivative/ 3446 19 artesunate/ 7915 20 artemether plus benflumetol/ 3729 21 artemether/ 3545 22 (atovaquone/ and proguanil/) or atovaquone plus proguanil/ 2343 23 quinine/ or quinine derivative/ 21607 24 mefloquine/ 8536 25 chloroquine/ 51941 26 primaquine/ 7437 27 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 113559 28 or/17-27 124688 29 exp randomized controlled trial/ 875272 30 controlled clinical trial/ 445547 31 randomized.ab. 988044 32 placebo.ab. 384201 33 randomly.ab. 605623 34 trial.ti. 461420 35 exp controlled study/ 11223314 36 cohort analysis/ 1297764 37 case-control.tw. 223870 38 (cohort adj (study or studies)).tw. 552220 39 cohort analy$.tw. 23144 40 (follow up adj (study or studies)).tw. 84453 41 observational study/ 421099 42 (observational adj (study or studies)).tw. 301470 43 longitudinal study/ 234053 44 longitudinal.tw. 504888 45 retrospective study/ 1771006 46 retrospective.tw. 1452335 47 cross-sectional study/ 703432 48 cross-sectional.tw. 793043 49 case study/ 115284 50 case-series.tw. 167295 51 or/29-50 14571712 52 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/ 1292095 53 animal experiment/ not (human experiment/ or human/) 2725813 54 52 or 53 2805969 55 51 not 54 12711391 56 16 and 28 and 55 1303 57 limit 56 to yr="2021 -Current" 248 58 remove duplicates from 57 245 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 10 Date searched: 2025-03-13 Searched by: JF Number of hits: 98 EndNote import number: 3 Number of results after deduplication: 21 1 plasmodium/ or plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 138195 2 malaria/ or airport malaria/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ or malariae malaria/ or ovale malaria/ or vivax malaria/ 113654 3 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 146004 4 or/1-3 [malaria all species] 150415 5 pregnancy/ or pregnant women/ or pregnant adolescents/ or pregnancy complications/ 167609 6 (pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 187303 7 placenta/ 11857 8 cord blood/ 5236 9 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 25169 10 exp vertical transmission/ 12634 11 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 11739 12 or/5-11 226721 13 antimalarials/ 32133 14 artemisinin/ 5775 15 artesunate/ 2730 16 artemether/ 2264 17 atovaquone/ and proguanil/ 404 18 quinine/ 8693 19 mefloquine/ 2454 20 chloroquine/ 12140 21 primaquine/ 2198 22 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab. 48431 23 or/13-22 [drugs] 53875 24 case-control studies/ 45924 25 cohort studies/ 113527 26 case-control.tw. 86017 27 (cohort adj (study or studies)).tw. 130123 28 cohort analy$.tw. 3626 29 (follow up adj (study or studies)).tw. 11130 30 observational studies/ 17401 31 (observational adj (study or studies)).tw. 51522 32 longitudinal studies/ 20081 33 longitudinal.tw. 74186 34 retrospective studies/ 51916 35 retrospective.tw. 139155 36 cross-sectional studies/ 51739 37 cross-sectional.tw. 255137 38 case-series.tw. 11751 39 randomized controlled trials/ 84203 40 randomized.ab. 131120 41 placebo.ab. 53903 42 randomly.ab. 138846 43 trial.ti. 58274 44 or/24-43 899828 45 exp animals/ not (man/ or human.sh.) 1127930 46 44 not 45 843808 47 4 and 12 and 23 and 46 719 48 limit 47 to yr="2021 -Current" 123 49 remove duplicates from 48 98 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to March 12, 2025 Date searched: 2025-03-13 Searched by: JF Number of hits: 162 EndNote import number: 1 Number of results after deduplication: 161 1 plasmodium/ or Plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ or malaria/ or malaria, vivax/ or exp Malaria, Falciparum/ or malaria, cerebral/ 93935 2 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 118603 3 or/1-2 [malaria all species] 127068 4 Pregnancy Complications, Parasitic/ 4138 5 Pregnancy Complications, Infectious/ 44100 6 exp Pregnancy/ or Pregnant Women/ or pregnancy complications/ or puerperal infection/ 1055308 7 (pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 720757 8 exp Placenta/ 79332 9 Fetal Blood/ 32677 10 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 158996 11 Infectious Disease Transmission, Vertical/ 19582 12 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 16008 13 or/4-12 1302918 14 Antimalarials/ 30444 15 Artemisinins/ 8127 16 Artesunate/ 2253 17 artemether/ or artemether, lumefantrine drug combination/ 1711 18 Atovaquone/ and Proguanil/ 373 19 Quinine/ 6782 20 Mefloquine/ 2250 21 (antimalarial* or anti-malarial* or artemisin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine).ti,ab,rn. 54971 22 Chloroquine/ 15767 23 Primaquine/ 2186 24 (chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 28266 25 or/14-24 [drugs] 71905 26 Epidemiologic studies/ 9671 27 exp case-control studies/ 1584103 28 exp Cohort Studies/ 2717916 29 case-control.tw. 169986 30 (cohort adj (study or studies)).tw. 387345 31 cohort analy$.tw. 14483 32 (follow up adj (study or studies)).tw. 59903 33 (observational adj (study or studies)).tw. 195692 34 longitudinal.tw. 369271 35 retrospective.tw. 882817 36 cross-sectional.tw. 613973 37 Cross-Sectional Studies/ 535249 38 case reports.pt. or (case-series or case reports).tw. 2594721 39 randomized controlled trial.pt. 633452 40 controlled clinical trial.pt. 95672 41 randomized.ab. 683050 42 placebo.ab. 256690 43 clinical trials as topic.sh. 204553 44 randomly.ab. 455002 45 trial.ti. 330803 46 or/26-45 7921033 47 exp animals/ not humans.sh. 5316086 48 46 not 47 7677703 49 3 and 13 and 25 and 48 1069 50 limit 49 to yr="2021 -Current" 162 51 remove duplicates from 50 162 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-03-10 Date searched: 2025-03-13 Searched by: JF Number of hits: 78 EndNote import number: 4 Number of results after deduplication: 0 1: TI=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") or AB=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") Results: 118974 2: TI=(pregnanc* or pregnant* or trimester* or obstetric*) or AB=(pregnanc* or pregnant* or trimester* or obstetric*) Results: 672261 3: TI=(placenta* or (("fetal" or "foetal" or "cord") near/2 blood*)) or AB=(placenta* or (("fetal" or "foetal" or "cord") near/2 blood*)) Results: 165940 4: TI=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) or AB=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) Results: 16597 5: #4 OR #3 OR #2 Results: 783306 6: TI=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") or AB=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") Results: 59032 7: TS=("case-control" or ("cohort" near/1 ("study" or "studies")) or "cohort analy*" or ("follow up" near/1 ("study" or "studies")) or ("observational" near/1 ("study" or "studies")) or "longitudinal" or "retrospective" or "cross-sectional" or "case-series") or AB=("randomized" or "placebo" or "randomly") or TI=("trial") Results: 4207350 8: TI=("rat" or "rats" or "mouse" or "mice" or "swine" or "porcine" or "murine" or "sheep" or "lambs" or "pigs" or "piglets" or "rabbit" or "rabbits" or "cat" or "cats" or "dog" or "dogs" or "cattle" or "bovine" or "monkey" or "monkeys" or "trout" or marmoset*) NOT TS=("man" or "human") Results: 2538742 9: #7 not #8 Results: 4102232 10: #9 AND #6 AND #5 AND #1 Results: 375 11: #10 Timespan: 2021-01-01 to 2025-12-31 Results: 78