Search strategy B for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic B was simply defined as: Falciparum malaria AND (anti-malaria drugs OR outpatients) AND non-endemic countries AND (randomised controlled trials OR observational studies OR case-series) Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 January 28 Date searched: 2025-01-29 Searched by: JF Number of hits: 881 EndNote import number: 2 Number of results after deduplication: 589 1 exp Plasmodium falciparum/ or exp malaria falciparum/ or exp cerebral malaria/ 62316 2 (falciparum or (severe adj2 malaria*)).ti,ab. 55511 3 1 or 2 [falciparum] 71083 4 antimalarial agent/ 31349 5 artemisinin derivative/ 3405 6 artesunate/ 7786 7 artemether plus benflumetol/ 3657 8 artemether/ 3491 9 (atovaquone/ and proguanil/) or atovaquone plus proguanil/ 2320 10 quinine/ or quinine derivative/ 21317 11 mefloquine/ 8429 12 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine).ti,ab,rn. 70210 13 or/4-12 [falciparum drugs] 83329 14 outpatient/ or outpatient care/ or outpatient department/ or exp ambulatory care/ 390361 15 (outpatient* or out-patient* or ambulatory or opat).ti,ab. 543190 16 or/14-15 [outpatients] 646279 17 travel/ or travel related disease/ or emporiatrics/ 72597 18 exp military personnel/ or military deployment/ or military service/ or military medicine/ 73506 19 clergy/ 7129 20 exp migrant/ or undocumented immigrant/ 57585 21 (non-endemic or "not endemic").ti,ab,kf. 7002 22 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab,kf. 369799 23 Albania/ or Albania.ti,ab,kf. 2873 24 Algeria/ or Algeria.ti,ab,kf. 8937 25 Andorra/ or Andorra.ti,ab,kf. 153 26 "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab,kf. 380 27 Argentina/ or Argentina.ti,ab,kf. 38124 28 Armenia/ or Armenia.ti,ab,kf. 3330 29 exp "Australia and New Zealand"/ or Australia.ti,ab,kf. 334562 30 Austria/ or Austria.ti,ab,kf. 37904 31 exp Azerbaijan/ or Azerbaijan.ti,ab,kf. 3529 32 Bahamas/ or Bahamas.ti,ab,kf. 1293 33 Bahrain/ or Bahrain.ti,ab,kf. 2773 34 Barbados/ or Barbados.ti,ab,kf. 1605 35 Belarus/ or Belarus.ti,ab,kf. 4255 36 exp Belgium/ or Belgium.ti,ab,kf. 43859 37 Belize/ or Belize.ti,ab,kf. 1360 38 exp "Bosnia and Herzegovina"/ or (Bosnia or Herzegovina).ti,ab,kf. 4866 39 Brunei Darussalam/ or Brunei.ti,ab,kf. 1015 40 Bulgaria/ or Bulgaria.ti,ab,kf. 14319 41 exp Canada/ or Canada.ti,ab,kf. 282205 42 Chile/ or Chile.ti,ab,kf. 30080 43 exp China/ or China.ti,ab,kf. 506389 44 Croatia/ or Croatia.ti,ab,kf. 16234 45 Cuba/ or Cuba.ti,ab,kf. 10457 46 Cyprus/ or Cyprus.ti,ab,kf. 4571 47 Czech Republic/ or (Czech Republic or Czechia).ti,ab,kf. 23157 48 exp Denmark/ or Denmark.ti,ab,kf. 78837 49 Dominica/ or Dominica.ti,ab,kf. 751 50 Egypt/ or Egypt.ti,ab,kf. 37367 51 El Salvador/ or El Salvador.ti,ab,kf. 3296 52 Estonia/ or Estonia.ti,ab,kf. 6311 53 Fiji/ or Fiji.ti,ab,kf. 4232 54 exp Finland/ or Finland.ti,ab,kf. 57289 55 exp France/ or France.ti,ab,kf. 202318 56 Gambia/ or Gambia.ti,ab,kf. 4417 57 exp "Georgia (Republic)"/ or Georgia.ti,ab,kf. 16474 58 exp Germany/ or Germany.ti,ab,kf. 296482 59 Greece/ or Greece.ti,ab,kf. 41982 60 Grenada/ or Grenada.ti,ab,kf. 588 61 Guyana/ or Guyana.ti,ab,kf. 2064 62 Hungary/ or Hungary.ti,ab,kf. 34242 63 Iceland/ or Iceland.ti,ab,kf. 9715 64 exp Iraq/ or Iraq.ti,ab,kf. 20363 65 Ireland/ or (Ireland or Eire).ti,ab,kf. 190680 66 Israel/ or Israel.ti,ab,kf. 52922 67 exp Italy/ or Italy.ti,ab,kf. 190752 68 Jamaica/ or Jamaica.ti,ab,kf. 6260 69 Japan/ or Japan.ti,ab,kf. 338551 70 Jordan/ or Jordan.ti,ab,kf. 14574 71 Kazakhstan/ or Kazakhstan.ti,ab,kf. 7154 72 Kiribati/ or Kiribati.ti,ab,kf. 333 73 Kuwait/ or Kuwait.ti,ab,kf. 7980 74 Kyrgyzstan/ or Kyrgyzstan.ti,ab,kf. 2555 75 Latvia/ or Latvia.ti,ab,kf. 4068 76 Lebanon/ or Lebanon.ti,ab,kf. 10585 77 Lesotho/ or Lesotho.ti,ab,kf. 1439 78 Libyan Arab Jamahiriya/ or Libya.ti,ab,kf. 2794 79 Liechtenstein/ or Liechtenstein.ti,ab,kf. 573 80 Lithuania/ or Lithuania.ti,ab,kf. 7009 81 Luxembourg/ or Luxembourg.ti,ab,kf. 2644 82 Maldives/ or Maldives.ti,ab,kf. 802 83 Malta/ or Malta.ti,ab,kf. 3491 84 marshall islands/ or Marshall Islands.ti,ab,kf. 487 85 Mauritius/ or Mauritius.ti,ab,kf. 1706 86 exp "Federated States of Micronesia"/ or Micronesia.ti,ab,kf. 1518 87 Moldova/ or Moldova.ti,ab,kf. 1938 88 Monaco/ or Monaco.ti,ab,kf. 1965 89 Mongolia/ or Mongolia.ti,ab,kf. 8588 90 "Montenegro (republic)"/ 1040 91 "Montenegro (republic)"/ or Montenegro.ti,ab,kf. 1862 92 Morocco/ or Morocco.ti,ab,kf. 14219 93 nauru/ or Nauru.ti,ab,kf. 235 94 Netherlands/ or (Netherlands or Holland).ti,ab,kf. 131166 95 New Zealand.ti,ab,kf. 88703 96 "Republic of North Macedonia"/ or North Macedonia.ti,ab,kf. 1624 97 exp Norway/ or Norway.ti,ab,kf. 72332 98 Oman/ or Oman.ti,ab,kf. 5815 99 Palau/ or Palau.ti,ab,kf. 631 100 Palestine/ or Palestine.ti,ab,kf. 3822 101 Paraguay/ or Paraguay.ti,ab,kf. 3177 102 Poland/ or Poland.ti,ab,kf. 78771 103 exp Portugal/ or Portugal.ti,ab,kf. 33987 104 Qatar/ or Qatar.ti,ab,kf. 6438 105 Romania/ or Romania.ti,ab,kf. 21554 106 exp Russian Federation/ or Russia.ti,ab,kf. 86489 107 "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab,kf. 272 108 Saint Lucia/ or Saint Lucia.ti,ab,kf. 212 109 "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab,kf. 448 110 exp samoan islands/ or Samoa.ti,ab,kf. 1702 111 San Marino/ or San Marino.ti,ab,kf. 219 112 exp Serbia/ or Serbia.ti,ab,kf. 11102 113 Seychelles/ or Seychelles.ti,ab,kf. 1090 114 Singapore/ or Singapore.ti,ab,kf. 39601 115 Slovakia/ or Slovakia.ti,ab,kf. 9489 116 Slovenia/ or Slovenia.ti,ab,kf. 8890 117 exp Spain/ or Spain.ti,ab,kf. 151194 118 Sri Lanka/ or Sri Lanka.ti,ab,kf. 14704 119 Sweden/ or Sweden.ti,ab,kf. 123240 120 Switzerland/ or Switzerland.ti,ab,kf. 82069 121 Syrian Arab Republic/ or Syria.ti,ab,kf. 5502 122 Tajikistan/ or Tajikistan.ti,ab,kf. 1569 123 Tonga/ or Tonga.ti,ab,kf. 766 124 "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab,kf. 4130 125 Tunisia/ or Tunisia.ti,ab,kf. 16770 126 "Turkey (republic)"/ or (Turkey or Turkiye).ti,ab,kf. 87284 127 Turkmenistan/ or Turkmenistan.ti,ab,kf. 951 128 Tuvalu/ or Tuvalu.ti,ab,kf. 125 129 exp Ukraine/ or Ukraine.ti,ab,kf. 24190 130 exp United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab,kf. 13786 131 exp United Kingdom/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab,kf. 771977 132 exp United States/ or (United States or America or USA).ti,ab,kf. 2040171 133 Uruguay/ or Uruguay.ti,ab,kf. 6030 134 exp Uzbekistan/ or Uzbekistan.ti,ab,kf. 3806 135 or/17-134 [non-endemic countries] 6350568 136 exp controlled study/ 11099553 137 cohort analysis/ 1266919 138 case-control.tw. 221105 139 (cohort adj (study or studies)).tw. 542042 140 cohort analy$.tw. 22740 141 (follow up adj (study or studies)).tw. 83502 142 observational study/ 409670 143 (observational adj (study or studies)).tw. 295783 144 longitudinal study/ 229368 145 longitudinal.tw. 497407 146 retrospective study/ 1735345 147 retrospective.tw. 1428571 148 cross-sectional study/ 687100 149 cross-sectional.tw. 778940 150 case study/ 114807 151 case-series.tw. 165042 152 exp randomized controlled trial/ 865884 153 controlled clinical trial/ 442137 154 randomized.ab. 975427 155 placebo.ab. 379920 156 randomly.ab. 598248 157 trial.ti. 454737 158 or/136-157 14386771 159 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/ 1273935 160 animal experiment/ not (human experiment/ or human/) 2684801 161 159 or 160 2764162 162 158 not 161 [study types] 12550496 163 3 and (13 or 16) and 135 and 162 1392 164 limit 163 to yr="2010 -Current" 885 165 remove duplicates from 164 881 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 04 Date searched: 2025-01-29 Searched by: JF Number of hits: 240 EndNote import number: 3 Number of results after deduplication: 59 1 plasmodium falciparum/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ 50085 2 falciparum.ti,ab. 47067 3 (severe adj2 malaria*).ti,ab. 4486 4 or/1-3 [falciparum] 53295 5 antimalarials/ 29343 6 artemisinin/ 4979 7 artesunate/ 2384 8 artemether/ 1852 9 atovaquone/ and proguanil/ 378 10 quinine/ 8484 11 mefloquine/ 2334 12 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine).ti,ab. 35941 13 or/5-12 [falciparum drugs] 45709 14 outpatient services/ 4460 15 (outpatient* or out-patient* or ambulatory or opat).ti,ab. 53169 16 or/14-15 [outpatients] 53354 17 travel/ or international travel/ 7627 18 travel associated diseases/ 757 19 travel medicine/ 2505 20 exp tourism/ 8851 21 exp military personnel/ 13980 22 military medicine/ 487 23 migrants/ or visitors/ 7139 24 immigrants/ or immigration/ 10856 25 refugees/ 6075 26 imported infections/ 9718 27 (non-endemic or "not endemic").ti,ab. 4620 28 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab. 112256 29 Albania/ or Albania.ti,ab. 1656 30 Algeria/ or Algeria.ti,ab. 7232 31 Andorra/ or Andorra.ti,ab. 55 32 exp "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab. 254 33 Argentina/ or Argentina.ti,ab. 18234 34 Armenia/ or Armenia.ti,ab. 1227 35 exp Australia/ or Australia.ti,ab. 80569 36 Austria/ or Austria.ti,ab. 11192 37 Azerbaijan/ or Azerbaijan.ti,ab. 2142 38 Bahamas/ or Bahamas.ti,ab. 355 39 Bahrain/ or Bahrain.ti,ab. 1075 40 Barbados/ or Barbados.ti,ab. 784 41 Belarus/ or Belarus.ti,ab. 1445 42 Belgium/ or Belgium.ti,ab. 14301 43 Belize/ or Belize.ti,ab. 767 44 bosnia-hercegovina/ or (Bosnia or Herzegovina).ti,ab. 2443 45 brunei darussalam/ or Brunei.ti,ab. 432 46 Bulgaria/ or Bulgaria.ti,ab. 7348 47 exp Canada/ or Canada.ti,ab. 67681 48 Chile/ or Chile.ti,ab. 11632 49 exp China/ or China.ti,ab. 303403 50 Croatia/ or Croatia.ti,ab. 6921 51 Cuba/ or Cuba.ti,ab. 6743 52 Cyprus/ or Cyprus.ti,ab. 2121 53 Czech Republic/ or (Czech Republic or Czechia).ti,ab. 8185 54 exp Denmark/ or Denmark.ti,ab. 23640 55 Dominica/ or Dominica.ti,ab. 437 56 exp Egypt/ or Egypt.ti,ab. 26365 57 El Salvador/ or El Salvador.ti,ab. 1816 58 Estonia/ or Estonia.ti,ab. 2524 59 Fiji/ or Fiji.ti,ab. 1724 60 exp Finland/ or Finland.ti,ab. 18826 61 exp France/ or France.ti,ab. 63142 62 Gambia/ or Gambia.ti,ab. 3985 63 "republic of georgia"/ or Georgia.ti,ab. 6734 64 exp Germany/ or Germany.ti,ab. 66522 65 exp Greece/ or Greece.ti,ab. 16480 66 Grenada/ or Grenada.ti,ab. 410 67 Guyana/ or Guyana.ti,ab. 1532 68 Hungary/ or Hungary.ti,ab. 9397 69 Iceland/ or Iceland.ti,ab. 2604 70 Iraq/ or Iraq.ti,ab. 9195 71 irish republic/ or (Ireland or Eire).ti,ab. 11514 72 Israel/ or Israel.ti,ab. 15460 73 exp Italy/ or Italy.ti,ab. 73673 74 Jamaica/ or Jamaica.ti,ab. 3426 75 exp Japan/ or Japan.ti,ab. 78058 76 Jordan/ or Jordan.ti,ab. 5861 77 Kazakhstan/ or Kazakhstan.ti,ab. 4389 78 Kiribati/ or Kiribati.ti,ab. 283 79 Kuwait/ or Kuwait.ti,ab. 2865 80 Kyrgyzstan/ or Kyrgyzstan.ti,ab. 1044 81 Latvia/ or Latvia.ti,ab. 2129 82 Lebanon/ or Lebanon.ti,ab. 4353 83 Lesotho/ or Lesotho.ti,ab. 1056 84 Libya/ or Libya.ti,ab. 1920 85 Liechtenstein/ or Liechtenstein.ti,ab. 126 86 Lithuania/ or Lithuania.ti,ab. 3109 87 Luxembourg/ or Luxembourg.ti,ab. 903 88 Maldives/ or Maldives.ti,ab. 429 89 Malta/ or Malta.ti,ab. 1749 90 marshall islands/ or Marshall Islands.ti,ab. 250 91 exp Mauritius/ or Mauritius.ti,ab. 1304 92 "federated states of micronesia"/ or micronesia.ti,ab. 488 93 Moldova/ or Moldova.ti,ab. 1073 94 Monaco/ or Monaco.ti,ab. 111 95 Mongolia/ or Mongolia.ti,ab. 3530 96 Montenegro/ or Montenegro.ti,ab. 1062 97 Morocco/ or Morocco.ti,ab. 10045 98 Nauru/ or Nauru.ti,ab. 185 99 Netherlands/ or (Netherlands or Holland).ti,ab. 38644 100 exp New Zealand/ or New Zealand.ti,ab. 23731 101 "republic of north macedonia"/ or North Macedonia.ti,ab. 1772 102 exp Norway/ or Norway.ti,ab. 18117 103 Oman/ or Oman.ti,ab. 2315 104 Palau/ or Palau.ti,ab. 235 105 exp Palestine/ or Palestine.ti,ab. 2996 106 Paraguay/ or Paraguay.ti,ab. 1998 107 Poland/ or Poland.ti,ab. 30952 108 exp Portugal/ or Portugal.ti,ab. 12246 109 Qatar/ or Qatar.ti,ab. 1713 110 Romania/ or Romania.ti,ab. 12744 111 exp Russia/ or Russia.ti,ab. 24313 112 exp "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab. 235 113 Saint Lucia/ or Saint Lucia.ti,ab. 474 114 exp "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab. 268 115 Samoa/ or American Samoa/ or Samoa.ti,ab. 1150 116 San Marino/ or San Marino.ti,ab. 77 117 exp Serbia/ or Serbia.ti,ab. 6095 118 exp Seychelles/ or Seychelles.ti,ab. 568 119 Singapore/ or Singapore.ti,ab. 9236 120 Slovakia/ or Slovakia.ti,ab. 5019 121 Slovenia/ or Slovenia.ti,ab. 4983 122 exp Spain/ or Spain.ti,ab. 58871 123 Sri Lanka/ or Sri Lanka.ti,ab. 9604 124 Sweden/ or Sweden.ti,ab. 32978 125 Switzerland/ or Switzerland.ti,ab. 19292 126 Syria/ or Syria.ti,ab. 2644 127 Tajikistan/ or Tajikistan.ti,ab. 1028 128 Tonga/ or Tonga.ti,ab. 473 129 exp "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab. 2789 130 Tunisia/ or Tunisia.ti,ab. 8843 131 Turkey/ or (Turkey or Turkiye).ti,ab. 55969 132 Turkmenistan/ or Turkmenistan.ti,ab. 783 133 Tuvalu/ or Tuvalu.ti,ab. 152 134 Ukraine/ or Ukraine.ti,ab. 5818 135 exp United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab. 4207 136 exp UK/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab. 138181 137 exp USA/ or (United States or America or USA).ti,ab. 472270 138 Uruguay/ or Uruguay.ti,ab. 3727 139 Uzbekistan/ or Uzbekistan.ti,ab. 2318 140 or/17-139 [non-endemic countries] 1842667 141 case-control studies/ 38287 142 cohort studies/ 100642 143 case-control.tw. 74521 144 (cohort adj (study or studies)).tw. 114946 145 cohort analy$.tw. 3268 146 (follow up adj (study or studies)).tw. 10354 147 observational studies/ 15119 148 (observational adj (study or studies)).tw. 43884 149 longitudinal studies/ 17370 150 longitudinal.tw. 66568 151 retrospective studies/ 45755 152 retrospective.tw. 124377 153 cross-sectional studies/ 43873 154 cross-sectional.tw. 212708 155 case-series.tw. 10159 156 randomized controlled trials/ 71407 157 randomized.ab. 114223 158 placebo.ab. 48869 159 randomly.ab. 125504 160 trial.ti. 52163 161 or/141-160 788070 162 exp animals/ not (man/ or human.sh.) 1088839 163 161 not 162 735538 164 4 and (13 or 16) and 140 and 163 471 165 limit 164 to yr="2010 -Current" 240 166 remove duplicates from 165 240 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to January 28, 2025 Date searched: 2025-01-29 Searched by: JF Number of hits: 354 EndNote import number: 1 Number of results after deduplication: 337 1 Plasmodium falciparum/ or exp Malaria, Falciparum/ or malaria, cerebral/ 43516 2 falciparum.ti,ab. 43225 3 (severe adj2 malaria*).ti,ab. 5012 4 or/1-3 [falciparum] 54471 5 Antimalarials/ 30353 6 Artemisinins/ 8083 7 Artesunate/ 2242 8 artemether/ or artemether, lumefantrine drug combination/ 1705 9 Atovaquone/ and Proguanil/ 372 10 Quinine/ 6775 11 Mefloquine/ 2249 12 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine).ti,ab,rn. 54723 13 or/5-12 [falciparum drugs] 54757 14 Outpatients/ 23342 15 Ambulatory Care/ 47465 16 (outpatient* or out-patient* or ambulatory or opat).ti,ab. 329041 17 or/14-16 346601 18 exp Travel/ or Travel Medicine/ 32959 19 Holidays/ 3359 20 Military Personnel/ or Military Medicine/ or Military Deployment/ 68329 21 exp "Emigrants and Immigrants"/ or Missionaries/ 17339 22 "Transients and Migrants"/ 15282 23 Communicable Diseases, Imported/ 609 24 (non-endemic or "not endemic").ti,ab,kf. 5342 25 (travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or ((army or navy or armed forces or air force) adj1 personnel) or expat* or missionar* or migrant? or immigrant? or emigrant? or refugee* or asylum or (import* adj2 (infect* or diseas*)) or (visit* adj2 (friend* or family or families or relativ* or relation*)) or vfr).ti,ab,kf. 296605 26 Albania/ or Albania.ti,ab,kf. 1783 27 Algeria/ or Algeria.ti,ab,kf. 5769 28 Andorra/ or Andorra.ti,ab,kf. 106 29 "Antigua and Barbuda"/ or (Antigua or Barbuda).ti,ab,kf. 332 30 Argentina/ or Argentina.ti,ab,kf. 28487 31 Armenia/ or Armenia.ti,ab,kf. 2445 32 exp Australia/ or Australia.ti,ab,kf. 231416 33 Austria/ or Austria.ti,ab,kf. 30897 34 Azerbaijan/ or Azerbaijan.ti,ab,kf. 2484 35 Bahamas/ or Bahamas.ti,ab,kf. 1048 36 Bahrain/ or Bahrain.ti,ab,kf. 1697 37 Barbados/ or Barbados.ti,ab,kf. 1276 38 "Republic of Belarus"/ or Belarus.ti,ab,kf. 3040 39 Belgium/ or Belgium.ti,ab,kf. 33098 40 Belize/ or Belize.ti,ab,kf. 1194 41 "Bosnia and Herzegovina"/ or (Bosnia or Herzegovina).ti,ab,kf. 3805 42 Brunei/ or Brunei.ti,ab,kf. 740 43 Bulgaria/ or Bulgaria.ti,ab,kf. 9369 44 exp Canada/ or Canada.ti,ab,kf. 241878 45 Chile/ or Chile.ti,ab,kf. 25314 46 exp China/ or China.ti,ab,kf. 472519 47 Croatia/ or Croatia.ti,ab,kf. 11339 48 Cuba/ or Cuba.ti,ab,kf. 7741 49 Cyprus/ or Cyprus.ti,ab,kf. 3249 50 Czech Republic/ or (Czech Republic or Czechia).ti,ab,kf. 14563 51 exp Denmark/ or Denmark.ti,ab,kf. 75575 52 Dominica/ or Dominica.ti,ab,kf. 646 53 Egypt/ or Egypt.ti,ab,kf. 28863 54 El Salvador/ or El Salvador.ti,ab,kf. 1847 55 Estonia/ or Estonia.ti,ab,kf. 4482 56 Fiji/ or Fiji.ti,ab,kf. 2884 57 Finland/ or Finland.ti,ab,kf. 52866 58 exp France/ or France.ti,ab,kf. 153902 59 Gambia/ or Gambia.ti,ab,kf. 3908 60 "Georgia (Republic)"/ or Georgia.ti,ab,kf. 13886 61 exp Germany/ or Germany.ti,ab,kf. 198582 62 Greece/ or Greece.ti,ab,kf. 29743 63 Grenada/ or Grenada.ti,ab,kf. 444 64 Guyana/ or Guyana.ti,ab,kf. 1574 65 Hungary/ or Hungary.ti,ab,kf. 25811 66 Iceland/ or Iceland.ti,ab,kf. 8059 67 Iraq/ or Iraq.ti,ab,kf. 12095 68 Ireland/ or (Ireland or Eire).ti,ab,kf. 38393 69 Israel/ or Israel.ti,ab,kf. 46395 70 exp Italy/ or Italy.ti,ab,kf. 159357 71 Jamaica/ or Jamaica.ti,ab,kf. 5197 72 exp Japan/ or Japan.ti,ab,kf. 244561 73 Jordan/ or Jordan.ti,ab,kf. 11272 74 Kazakhstan/ or Kazakhstan.ti,ab,kf. 5301 75 Kiribati.ti,ab,kf. 286 76 Kuwait/ or Kuwait.ti,ab,kf. 5632 77 Kyrgyzstan/ or Kyrgyzstan.ti,ab,kf. 2002 78 Latvia/ or Latvia.ti,ab,kf. 2674 79 Lebanon/ or Lebanon.ti,ab,kf. 8805 80 Lesotho/ or Lesotho.ti,ab,kf. 1165 81 Libya/ or Libya.ti,ab,kf. 2149 82 Liechtenstein/ or Liechtenstein.ti,ab,kf. 449 83 Lithuania/ or Lithuania.ti,ab,kf. 5356 84 Luxembourg/ or Luxembourg.ti,ab,kf. 1724 85 Maldives/ or Maldives.ti,ab,kf. 589 86 Malta/ or Malta.ti,ab,kf. 2056 87 Marshall Islands.ti,ab,kf. 376 88 Mauritius/ or Mauritius.ti,ab,kf. 1386 89 exp Micronesia/ or Micronesia.ti,ab,kf. 2727 90 Moldova/ or Moldova.ti,ab,kf. 1258 91 Monaco/ or Monaco.ti,ab,kf. 623 92 Mongolia/ or Mongolia.ti,ab,kf. 7221 93 Montenegro/ or Montenegro.ti,ab,kf. 1190 94 Morocco/ or Morocco.ti,ab,kf. 11082 95 Nauru.ti,ab,kf. 177 96 Netherlands/ or (Netherlands or Holland).ti,ab,kf. 107159 97 New Zealand/ or New Zealand.ti,ab,kf. 86975 98 "Republic of North Macedonia"/ or North Macedonia.ti,ab,kf. 892 99 exp Norway/ or Norway.ti,ab,kf. 64735 100 Oman/ or Oman.ti,ab,kf. 4932 101 Palau/ or Palau.ti,ab,kf. 555 102 Palestine.ti,ab,kf. 2590 103 Paraguay/ or Paraguay.ti,ab,kf. 2297 104 Poland/ or Poland.ti,ab,kf. 68109 105 Portugal/ or Portugal.ti,ab,kf. 25566 106 Qatar/ or Qatar.ti,ab,kf. 4240 107 Romania/ or Romania.ti,ab,kf. 16353 108 exp Russia/ or Russia.ti,ab,kf. 68638 109 "Saint Kitts and Nevis"/ or (Saint Kitts or Nevis).ti,ab,kf. 242 110 Saint Lucia/ or Saint Lucia.ti,ab,kf. 151 111 "Saint Vincent and the Grenadines"/ 59 112 "Saint Vincent and the Grenadines"/ or (Saint Vincent or Grenadines).ti,ab,kf. 312 113 exp Samoa/ or Samoa.ti,ab,kf. 1443 114 San Marino/ or San Marino.ti,ab,kf. 151 115 Serbia/ or Serbia.ti,ab,kf. 7487 116 Seychelles/ or Seychelles.ti,ab,kf. 1001 117 Singapore/ or Singapore.ti,ab,kf. 25733 118 Slovakia/ or Slovakia.ti,ab,kf. 6204 119 Slovenia/ or Slovenia.ti,ab,kf. 5999 120 Spain/ or Spain.ti,ab,kf. 126326 121 Sri Lanka/ or Sri Lanka.ti,ab,kf. 11396 122 Sweden/ or Sweden.ti,ab,kf. 110630 123 Switzerland/ or Switzerland.ti,ab,kf. 57953 124 Syria/ or Syria.ti,ab,kf. 4879 125 Tajikistan/ or Tajikistan.ti,ab,kf. 1328 126 Tonga/ or Tonga.ti,ab,kf. 684 127 "Trinidad and Tobago"/ or (Trinidad or Tobago).ti,ab,kf. 3295 128 Tunisia/ or Tunisia.ti,ab,kf. 12939 129 Turkey/ or (Turkey or Turkiye).ti,ab,kf. 69988 130 Turkmenistan/ or Turkmenistan.ti,ab,kf. 912 131 Tuvalu.ti,ab,kf. 96 132 Ukraine/ or Ukraine.ti,ab,kf. 21199 133 United Arab Emirates/ or (United Arab Emirates or UAE).ti,ab,kf. 9690 134 exp United Kingdom/ or (United Kingdom or Britain or UK or GBR or England or Scotland or Wales).ti,ab,kf. 563105 135 exp United States/ or (United States or America or USA).ti,ab,kf. 1865174 136 Uruguay/ or Uruguay.ti,ab,kf. 4338 137 Uzbekistan/ or Uzbekistan.ti,ab,kf. 2698 138 or/18-137 [ALL NON-ENDEMIC MALARIA COUNTRIES] 5289664 139 Epidemiologic studies/ 9650 140 exp case-control studies/ 1572207 141 exp Cohort Studies/ 2701389 142 case-control.tw. 168786 143 (cohort adj (study or studies)).tw. 381823 144 cohort analy$.tw. 14264 145 (follow up adj (study or studies)).tw. 59678 146 (observational adj (study or studies)).tw. 193395 147 longitudinal.tw. 365704 148 retrospective.tw. 872360 149 cross-sectional.tw. 606209 150 Cross-Sectional Studies/ 530173 151 case-series.tw. 117902 152 randomized controlled trial.pt. 631246 153 controlled clinical trial.pt. 95682 154 randomized.ab. 678358 155 placebo.ab. 255726 156 clinical trials as topic.sh. 204271 157 randomly.ab. 452081 158 trial.ti. 328185 159 or/139-158 5541312 160 exp animals/ not humans.sh. 5301552 161 159 not 160 5336635 162 4 and (13 or 17) and 138 and 161 709 163 limit 162 to yr="2010 -Current" [falciparum FINAL] 354 164 remove duplicates from 163 354 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-01-26 Date searched: 2025-01-29 Searched by: JF Number of hits: 183 EndNote import number: 4 Number of results after deduplication: 10 1: TI=("falciparum" or ("severe" near/2 malaria*)) or AB=("falciparum" or ("severe" near/2 malaria*)) Results: 45960 2: TI=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine") or AB=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine") Results: 43458 3: TI=(outpatient* or out-patient* or "ambulatory" or "opat") or AB=(outpatient* or out-patient* or "ambulatory" or "opat") Results: 304343 4: TI=(travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or (("army" or "navy" or "armed forces" or "air force") near/1 "personnel") or expat* or missionar* or migrant$ or immigrant$ or emigrant$ or refugee* or "asylum" or (import* near/2 (infect* or diseas*)) or (visit* near/2 (friend* or "family" or "families" or relativ* or relation*)) or "vfr") or AB=(travel* or emporiatric* or touris* or holiday* or vacation* or militar* or soldier* or troop* or sailor* or (("army" or "navy" or "armed forces" or "air force") near/1 "personnel") or expat* or missionar* or migrant$ or immigrant$ or emigrant$ or refugee* or "asylum" or (import* near/2 (infect* or diseas*)) or (visit* near/2 (friend* or "family" or "families" or relativ* or relation*)) or "vfr") Results: 888468 5: TI=("Albania" or "Algeria" or "Andorra" or "Antigua" or "Barbuda" or "Argentina" or "Armenia" or "Australia" or "Austria" or "Azerbaijan" or "Bahamas" or "Bahrain" or "Barbados" or "Belarus" or "Belgium" or "Belize" or "Bosnia" or "Herzegovina" or "Brunei" or "Bulgaria" or "Canada" or "Chile" or "China" or "Croatia" or "Cuba" or "Cyprus" or "Czech Republic" or "Czechia" or "Denmark" or "Dominica" or "Egypt" or "El Salvador" or "Estonia" or "Fiji" or "Finland" or "France" or "Gambia" or "Georgia" or "Germany" or "Greece" or "Grenada" or "Guyana" or "Hungary" or "Iceland" or "Iraq" or "Ireland" or "Eire" or "Israel" or "Italy" or "Jamaica" or "Japan" or "Jordan" or "Kazakhstan" or "Kiribati" or "Kuwait" or "Kyrgyzstan" or "Latvia" or "Lebanon" or "Lesotho" or "Libya" or "Liechtenstein" or "Lithuania" or "Luxembourg" or "Maldives" or "Malta" or "Marshall Islands" or "Mauritius" or "Micronesia" or "Moldova" or "Monaco" or "Mongolia" or "Montenegro" or "Morocco" or "Nauru" or "Netherlands" or "Holland" or "New Zealand" or "North Macedonia" or "Norway" or "Oman" or "Palau" or "Palestine" or "Paraguay" or "Poland" or "Portugal" or "Qatar" or "Romania" or "Russia" or "Saint Kitts" or "Nevis" or "Saint Lucia" or "Saint Vincent" or "Grenadines" or "Samoa" or "San Marino" or "Serbia" or "Seychelles" or "Singapore" or "Slovakia" or "Slovenia" or "Spain" or "Sri Lanka" or "Sweden" or "Switzerland" or "Syria" or "Tajikistan" or "Tonga" or "Trinidad" or "Tobago" or "Tunisia" or "Turkey" or "Turkiye" or "Turkmenistan" or "Tuvalu" or "Ukraine" or "United Arab Emirates" or "UAE" or "United Kingdom" or "Britain" or "UK" or "GBR" or "England" or "Scotland" or "Wales" or "United States" or "America" or "USA" or "Uruguay" or "Uzbekistan") Results: 2895885 6: AB=("Albania" or "Algeria" or "Andorra" or "Antigua" or "Barbuda" or "Argentina" or "Armenia" or "Australia" or "Austria" or "Azerbaijan" or "Bahamas" or "Bahrain" or "Barbados" or "Belarus" or "Belgium" or "Belize" or "Bosnia" or "Herzegovina" or "Brunei" or "Bulgaria" or "Canada" or "Chile" or "China" or "Croatia" or "Cuba" or "Cyprus" or "Czech Republic" or "Czechia" or "Denmark" or "Dominica" or "Egypt" or "El Salvador" or "Estonia" or "Fiji" or "Finland" or "France" or "Gambia" or "Georgia" or "Germany" or "Greece" or "Grenada" or "Guyana" or "Hungary" or "Iceland" or "Iraq" or "Ireland" or "Eire" or "Israel" or "Italy" or "Jamaica" or "Japan" or "Jordan" or "Kazakhstan" or "Kiribati" or "Kuwait" or "Kyrgyzstan" or "Latvia" or "Lebanon" or "Lesotho" or "Libya" or "Liechtenstein" or "Lithuania" or "Luxembourg" or "Maldives" or "Malta" or "Marshall Islands" or "Mauritius" or "Micronesia" or "Moldova" or "Monaco" or "Mongolia" or "Montenegro" or "Morocco" or "Nauru" or "Netherlands" or "Holland" or "New Zealand" or "North Macedonia" or "Norway" or "Oman" or "Palau" or "Palestine" or "Paraguay" or "Poland" or "Portugal" or "Qatar" or "Romania" or "Russia" or "Saint Kitts" or "Nevis" or "Saint Lucia" or "Saint Vincent" or "Grenadines" or "Samoa" or "San Marino" or "Serbia" or "Seychelles" or "Singapore" or "Slovakia" or "Slovenia" or "Spain" or "Sri Lanka" or "Sweden" or "Switzerland" or "Syria" or "Tajikistan" or "Tonga" or "Trinidad" or "Tobago" or "Tunisia" or "Turkey" or "Turkiye" or "Turkmenistan" or "Tuvalu" or "Ukraine" or "United Arab Emirates" or "UAE" or "United Kingdom" or "Britain" or "UK" or "GBR" or "England" or "Scotland" or "Wales" or "United States" or "America" or "USA" or "Uruguay" or "Uzbekistan") Results: 4764617 7: TI=("non-endemic" or "not endemic") or AB=("non-endemic" or "not endemic") Results: 5321 8: #4 OR #5 OR #6 OR #7 Results: 6962528 9: TS=("case-control" or ("cohort" near/1 ("study" or "studies")) or "cohort analy*" or ("follow up" near/1 ("study" or "studies")) or ("observational" near/1 ("study" or "studies")) or "longitudinal" or "retrospective" or "cross-sectional" or "case-series") or AB=("randomized" or "placebo" or "randomly") or TI=("trial") Results: 4158472 10: TI=("rat" or "rats" or "mouse" or "mice" or "swine" or "porcine" or "murine" or "sheep" or "lambs" or "pigs" or "piglets" or "rabbit" or "rabbits" or "cat" or "cats" or "dog" or "dogs" or "cattle" or "bovine" or "monkey" or "monkeys" or "trout" or marmoset*) NOT TS=("man" or "human") Results: 2530928 11: #9 not #10 Results: 4054065 12: #1 and (#2 or #3) and #8 and #11 Results: 270 13: #12 Timespan: 2010-01-01 to 2025-12-31 Results: 183