Search strategy H for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic H was simply defined as: Malaria [all species] AND pregnancy AND treatment failure AND (randomised controlled trials or observational studies) Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 January 27 Date searched: 2025-01-28 Searched by: JF Number of hits: 270 EndNote import number: 2 Number of results after deduplication: 173 1 exp breast feeding/ or mother/ or adolescent mother/ or expectant mother/ or exp pregnancy/ or pregnant woman/ or exp infectious pregnancy complication/ or pregnancy complication/ or maternal infection/ or puerperal infection/ 1208110 2 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 1426548 3 exp mother to child transmission/ or vertical transmission/ 21283 4 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 19563 5 or/1-4 [pregancy] 1791458 6 malaria/ or exp cerebral malaria/ or exp malaria falciparum/ or placenta malaria/ or plasmodium knowlesi malaria/ or plasmodium malariae infection/ or plasmodium ovale malaria/ or plasmodium vivax malaria/ 122502 7 plasmodium/ or exp plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 69514 8 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 146901 9 or/6-8 [malaria all species] 174009 10 antimalarial agent/ 31345 11 artemisinin derivative/ 3404 12 artesunate/ 7785 13 artemether plus benflumetol/ 3657 14 artemether/ 3491 15 (atovaquone/ and proguanil/) or atovaquone plus proguanil/ 2320 16 quinine/ or quinine derivative/ 21317 17 mefloquine/ 8429 18 chloroquine/ 51173 19 primaquine/ 7317 20 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 111886 21 treatment failure/ or "lack of drug effect"/ 202287 22 recurrent disease/ 237111 23 exp reinfection/ 39403 24 relapse/ or recrudescence/ 193331 25 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 3406623 26 or/10-25 [drugs and treatment failure] 3656287 27 exp controlled study/ 11095169 28 cohort analysis/ 1266215 29 case-control.tw. 221045 30 (cohort adj (study or studies)).tw. 541718 31 cohort analy$.tw. 22732 32 (follow up adj (study or studies)).tw. 83486 33 observational study/ 409414 34 (observational adj (study or studies)).tw. 295611 35 longitudinal study/ 229244 36 longitudinal.tw. 497241 37 retrospective study/ 1734594 38 retrospective.tw. 1427994 39 cross-sectional study/ 686694 40 cross-sectional.tw. 778544 41 case study/ 114749 42 case-series.tw. 164984 43 exp randomized controlled trial/ 865508 44 controlled clinical trial/ 442132 45 randomized.ab. 975124 46 placebo.ab. 379852 47 randomly.ab. 598059 48 trial.ti. 454571 49 or/27-48 14381420 50 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/ 1273685 51 animal experiment/ not (human experiment/ or human/) 2684295 52 50 or 51 2763606 53 49 not 52 [study types] 12545634 54 5 and 9 and 26 and 53 1586 55 limit 54 to yr="2021 -Current" 272 56 remove duplicates from 55 270 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 04 Date searched: 2025-01-28 Searched by: JF Number of hits: 112 EndNote import number: 3 Number of results after deduplication: 26 1 exp breast feeding/ or mothers/ or pregnancy/ or pregnant women/ or pregnant adolescents/ or pregnancy complications/ 194335 2 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 268259 3 exp vertical transmission/ or transmammary transmission/ 10841 4 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 9700 5 or/1-4 [pregnancy] 287299 6 plasmodium/ or plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 126886 7 malaria/ or airport malaria/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ or malariae malaria/ or ovale malaria/ or vivax malaria/ 102888 8 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 133558 9 or/6-8 [malaria all species] 137750 10 antimalarials/ 29343 11 artemisinin/ 4979 12 artesunate/ 2384 13 artemether/ 1852 14 atovaquone/ and proguanil/ 378 15 quinine/ 8484 16 mefloquine/ 2334 17 chloroquine/ 11364 18 primaquine/ 2059 19 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab. 44843 20 treatment failure/ 10766 21 reinfection/ 6454 22 relapse/ 33353 23 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 260307 24 or/10-23 [drugs and treatment failure] 304017 25 case-control studies/ 38287 26 cohort studies/ 100642 27 case-control.tw. 74521 28 (cohort adj (study or studies)).tw. 114946 29 cohort analy$.tw. 3268 30 (follow up adj (study or studies)).tw. 10354 31 observational studies/ 15119 32 (observational adj (study or studies)).tw. 43884 33 longitudinal studies/ 17370 34 longitudinal.tw. 66568 35 retrospective studies/ 45755 36 retrospective.tw. 124377 37 cross-sectional studies/ 43873 38 cross-sectional.tw. 212708 39 case-series.tw. 10159 40 randomized controlled trials/ 71407 41 randomized.ab. 114223 42 placebo.ab. 48869 43 randomly.ab. 125504 44 trial.ti. 52163 45 or/25-44 788070 46 exp animals/ not (man/ or human.sh.) 1088839 47 45 not 46 735538 48 5 and 9 and 24 and 47 650 49 limit 48 to yr="2021 -Current" 112 50 remove duplicates from 49 112 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to January 27, 2025 Date searched: 2025-01-28 Searched by: JF Number of hits: 160 EndNote import number: 1 Number of results after deduplication: 159 1 exp Breast Feeding/ or Mothers/ or exp Pregnancy/ or Pregnant Women/ or pregnancy complications/ or pregnancy complications, infectious/ or pregnancy complications, parasitic/ or puerperal infection/ 1118516 2 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 1027119 3 Infectious Disease Transmission, Vertical/ 19494 4 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 15912 5 or/1-4 1486325 6 plasmodium/ or Plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ or malaria/ or malaria, vivax/ or exp Malaria, Falciparum/ or malaria, cerebral/ 93644 7 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 118095 8 or/6-7 [malaria all species] 126554 9 Antimalarials/ 30353 10 Artemisinins/ 8082 11 Artesunate/ 2241 12 artemether/ or artemether, lumefantrine drug combination/ 1705 13 Atovaquone/ and Proguanil/ 372 14 Quinine/ 6773 15 Mefloquine/ 2249 16 Chloroquine/ 15742 17 Primaquine/ 2185 18 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 71549 19 treatment failure/ 38020 20 recurrence/ or reinfection/ 206234 21 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 2233105 22 or/9-21 [drugs and treatment failure] 2371475 23 Epidemiologic studies/ 9649 24 exp case-control studies/ 1571755 25 exp Cohort Studies/ 2700660 26 case-control.tw. 168740 27 (cohort adj (study or studies)).tw. 381620 28 cohort analy$.tw. 14260 29 (follow up adj (study or studies)).tw. 59672 30 (observational adj (study or studies)).tw. 193256 31 longitudinal.tw. 365579 32 retrospective.tw. 871948 33 cross-sectional.tw. 605931 34 Cross-Sectional Studies/ 529966 35 case-series.tw. 117860 36 randomized controlled trial.pt. 630956 37 controlled clinical trial.pt. 95680 38 randomized.ab. 678019 39 placebo.ab. 255655 40 clinical trials as topic.sh. 204259 41 randomly.ab. 451922 42 trial.ti. 327957 43 or/23-42 [study types] 5539583 44 exp animals/ not humans.sh. 5300982 45 43 not 44 5334943 46 5 and 8 and 22 and 45 1089 47 limit 46 to yr="2021 -Current" 161 48 remove duplicates from 47 160 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-01-25 Date searched: 2025-01-28 Searched by: JF Number of hits: 92 EndNote import number: 4 Number of results after deduplication: 3 1: TI=(mother* or "maternal" or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*) or AB=(mother* or "maternal" or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*) Results: 1069904 2: TI=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) or AB=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) Results: 16462 3: #2 OR #1 Results: 1075682 4: TI=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") or AB=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") Results: 118162 5: TI=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") or AB=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") Results: 58689 6: TI=(fail* or recurr* or reinfect* or relaps* or recrudesc*) or AB=(fail* or recurr* or reinfect* or relaps* or recrudesc*) Results: 3004404 7: #6 OR #5 Results: 3058214 8: TS=("case-control" or ("cohort" near/1 ("study" or "studies")) or "cohort analy*" or ("follow up" near/1 ("study" or "studies")) or ("observational" near/1 ("study" or "studies")) or "longitudinal" or "retrospective" or "cross-sectional" or "case-series") or AB=("randomized" or "placebo" or "randomly") or TI=("trial") Results: 4158092 9: TI=("rat" or "rats" or "mouse" or "mice" or "swine" or "porcine" or "murine" or "sheep" or "lambs" or "pigs" or "piglets" or "rabbit" or "rabbits" or "cat" or "cats" or "dog" or "dogs" or "cattle" or "bovine" or "monkey" or "monkeys" or "trout" or marmoset*) NOT TS=("man" or "human") Results: 2530879 10: #8 not #9 Results: 4053691 11: #3 AND #4 AND #7 AND #10 Results: 462 12: #11 Timespan: 2021-01-01 to 2025-12-31 Results: 92